Celiac disease in first-degree relatives of patients

Abstract

Celiac disease prevalence in this group of relatives was high. All new cases identified were symptomatic or had associated conditions. In this group, there was a high frequency of individuals with positive serological tests, symptoms suggestive of celiac disease, and no evidence of villous atrophy in the intestinal mucosa.

Risk of Celiac Disease in the First- and Second-Degree Relatives of Patients With Celiac Disease: A Systematic Review and Meta-Analysis

“…Forty-eight studies were included in this part of analysis as they reported serological prevalence among FDRs with one index case of CD ( 9,(11)(12)(13)(14)(30)(31)(32)(33)(34)(35)(36)39,(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(52)(53)(54)(55)(56)(57)(58)(59)(60)(63)(64)(65)(66)(67)(68)(69)(70)(71)(72)(73)(74)(75)(76)(77)(78). Overall, of 14,225 FDRs screened using AEA and/or anti-tTG Ab, 1,016 FDRs were seropositive ( 9,(11)…”

“…Of the 41 studies, 24 studies further mentioned prevalence of CD according to the relationship of FDRs with the index patient with CD ( 9,(12)(13)(14)(32)(33)(34)36,37,41,42,44,46,47,49,50,(52)(53)(54)(55)57,59,60,76 ). Of 2,780 siblings in these studies, 254 had CD, therefore pooled prevalence of CD in siblings was 8.9% (95% CI 6.6, 11.2%).…”

Prevalence and clinical features of celiac disease in patients with hepatitis B virus infection in Southern Brazil

“…There are few studies regarding the prevalence of celiac disease in the general population of the Americas, and almost none of these studies have included intestinal biopsies to confi rm the diagnosis 33 . Serological screening studies conducted in Brazil have shown a positivity rate of 0.15% to 1.7% [34][35][36] . In Curitiba, Paraná, the prevalence was one in 417 blood donors 32 .…”

Global epidemiology of celiac disease

“…Castro-Antunes и соавт. из 174 родственников первой линии, которым про-водилось серологическое обследование, у 20,1% (у 34 из 174) выявлены антитела IgA к тканевой трансглутаминазе (95% доверительный интервал 14,6-26,5), а у 22 из 23 родственников, которым проводилось морфологическое исследование, установлен диагноз целиакии [39].…”