Celiac Disease Could be a Frequent Disease in Mexico: Prevalence of Tissue Transglutaminase Antibody in Healthy Blood Donors

Troche, José María Remes; Ramírez-Iglesias, María Teresa; Rubio–Tapia, Alberto; Alonso-Ramos, Amada; Velázquez, Antonio; Uscanga, Luis

doi:10.1097/00004836-200609000-00007

Cited by 84 publications

(34 citation statements)

References 35 publications

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“…It is foreseeable that the autoantibodies generated against the neo-epitope may represent the best means for screening populations, diagnosing high-risk groups and identify silent or latent patients. In fact, several studies have shown the superiority of screening for CD using the neo-tTg/DGPs complex strategy in the general population [26,27] or in high-risk groups' subjects [16,18,19,[28][29][30]. The present results go along this serological diagnostic strategy and add the aspect of intestinal damage reflection.…”

Section: Discussionsupporting

confidence: 54%

Comparison of the Reliability of 17 Celiac Disease Associated Bio-Markers to Reflect Intestinal Damage

Lerner¹,

Jeremias²,

Neidhöfer³

et al. 2017

J Clin Cell Immunol

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Section: Discussionsupporting

confidence: 54%

Comparison of the Reliability of 17 Celiac Disease Associated Bio-Markers to Reflect Intestinal Damage

Lerner¹,

Jeremias²,

Neidhöfer³

et al. 2017

J Clin Cell Immunol

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“…Se sabe que esta enfermedad es más común en las mujeres, llegando del 73% al 80%; este patrón ha sido descrito por muchos autores (23,25,26). Sin embargo, en ocasiones, la enfermedad celíaca ha sido descrita como más frecuente entre los hombres, sobre todo en la evaluación de ensayos que utilizaron bancos de sangre; esto ocurre porque la mayoría de los donantes de sangre son hombres (27,28). En este estudio, al momento del diagnóstico, el con enfermedad celíaca y 304 con síndromes funcionales.…”

Section: Discussionunclassified

El efecto de la dieta libre de gluten en la alanina- aminotransferasa (ALT) en pacientes celíacos

Hatanaka

Silva

Dantas-Corrêa

et al. 2016

Rev. Colomb. Gastroenterol.

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El efecto de la dieta libre de gluten en la alaninaaminotransferasa (ALT) en pacientes celíacosThe effect of a gluten-free diet on alanine aminotransferase (ALT) in celiac patients ResumenIntroducción: la enfermedad celíaca es una enfermedad autoinmune provocada por la ingestión de gluten que afecta aproximadamente al 0,5%-1% de la población mundial. Las señales extraintestinales incluyen elevados niveles de alanina-aminotransferasa (ALT). Objetivo: evaluar los efectos de una dieta libre de gluten en los niveles ALT en pacientes con enfermedad celíaca. Métodos: este estudio transversal se llevó a cabo en la clínica ambulatoria de gastroenterología de un hospital universitario. Resultados: se incluyeron veintiséis pacientes con enfermedad celíaca con edad de 34,1 ± 11,4 años; 15,4% fueron hombres. Los sujetos del estudio tenían un nivel promedio de ALT de 54,6 ± 36,3 (mediana 40,5) U/L. Hubo una mayor proporción de individuos con hepatitis B en el grupo con ALT ≥50 U/L en comparación con sujetos con ALT <50 U/L. Entre los pacientes evaluados después del tratamiento con dieta libre de gluten se observó una reducción significativa de los valores de ALT (36,0 versus 31,0 U/l; p= 0,008). Conclusión: el treinta y cinco por ciento de los pacientes con enfermedad celíaca tenía ALT por encima del tercil superior. Se encontraron niveles más altos de ALT en pacientes con hepatitis viral B y en aquéllos que no se adhirieron a la dieta. Hubo una reducción de aminotransferasas como resultado de una dieta libre de gluten. Palabras claveTransaminasas, enfermedad celíaca, alanina-transaminasa, aminotransferasas aspartato, dieta, libre de gluten. AbstractIntroduction: Celiac disease is an autoimmune disease triggered by ingestion of gluten. It affects approximately 0.5% to 1% of the world population. Extra intestinal manifestations include elevated alanine aminotransferase (ALT) levels. Objective: The objective of this study was to evaluate the effects of a gluten-free diet on ALT levels in patients with celiac disease. Methods: This cross-sectional study was conducted in the gastroenterology outpatient clinic of a university hospital. Results: Twenty-six patients with celiac disease were included. Average patient age was 34.1 ± 11.4 years, and 15.4% of the patients were men. Study subjects had a mean ALT level of 54.6 ± 36.3 U/L (median 40.5). There was a higher proportion of individuals with hepatitis B in the group with ALT ≥ 50 U/L than in the group of subjects with ALT < 50 U/L. Among patients tested after treatment with a gluten-free diet, we observed a significant reduction in ALT values (36.0 vs. 31.0 U/L; P = 0.008). Conclusion: Thirty-five percent of celiac disease patients had ALT levels above the upper tertile. Higher ALT levels were found in patients with viral hepatitis B and in those who do not adhere to the diet. There was a reduction of aminotransferases with a gluten-free diet.

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“…Until 30 years ago, the prevalence of CD in Europe ranged between 1/1000-6500; hence, we considered an uncommon disease. However, in more recent years the prevalence was reported to become 1/83-1/500 from the population surveys conducted in various European countries using serological procedures (6)(7)(8).…”

Section: Discussionmentioning

confidence: 99%

Subclinical Celiac Disease Presented with Postpartum Low Back Pain Case Report

Baldane¹,

İpekçi²,

Şahin³

et al. 2015

Turk J Phys Med Rehab

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A 35-year-old woman was admitted with severe low back pain. The patient, who gave birth 5 months ago, was then breastfeeding and presented with postpartum low back pain with increasing severity. Her laboratory results revealed anemia, hypocalcemia, severe vitamin D deficiency, and increase in alkaline phosphatase (ALP) and parathyroid hormone (PTH) levels. Dual energy X-ray absorptiometry (DXA) scan demonstrated lumbar vertebral T and Z scores of -5.1 and -4.4, respectively. The serologic tests for celiac disease (CD) to search underlying malabsorption were positive. Histological analysis of the duodenal biopsy specimen revealed results consistent with the diagnosis of CD. However, because of an absence of gastrointestinal complaints, the diagnosis of subclinical CD could have been made when malabsorption resulted in osteoporosis associated with severe vitamin D deficiency. The initiation of vitamin D therapy showed a significant increase after 6 months at the lumbar vertebra T and Z scores of -0.7 and -0.2, respectively.

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Celiac Disease Could be a Frequent Disease in Mexico: Prevalence of Tissue Transglutaminase Antibody in Healthy Blood Donors

Cited by 84 publications

References 35 publications

Comparison of the Reliability of 17 Celiac Disease Associated Bio-Markers to Reflect Intestinal Damage

Comparison of the Reliability of 17 Celiac Disease Associated Bio-Markers to Reflect Intestinal Damage

El efecto de la dieta libre de gluten en la alanina- aminotransferasa (ALT) en pacientes celíacos

Subclinical Celiac Disease Presented with Postpartum Low Back Pain Case Report

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