Celiac Disease Associated with Dilated Cardiomyopathy

Lodha, Ankur; Haran, Mehandi; Hollander, Gerald; Frankel, Robert; Shani, Jacob

doi:10.1097/smj.0b013e3181b64dd9

Cited by 11 publications

(7 citation statements)

References 18 publications

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“…This sex distribution is consistent with earlier data on DCM, 23,24 as well as data on patients with CD and DCM. 25 Although the proportion of males in reference individuals with DCM in this cohort was lower (50%), it did not attain statistical significance.…”

Section: Discussionmentioning

confidence: 61%

Risk of Idiopathic Dilated Cardiomyopathy in 29 000 Patients With Celiac Disease

Emilsson

Andersson

Elfström

et al. 2012

JAHA

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BackgroundDilated cardiomyopathy (DCM) is a rare disease of largely unknown origin. Previous studies have suggested an increased prevalence of celiac disease (CD) in patients with DCM. These studies, however, were based on a maximum of 5 patients with both CD and DCM. In the present large Swedish population-based cohort study, we examined the risk of idiopathic DCM in patients with CD determined by small-intestinal histopathology.Methods and ResultsFrom 2006 to 2008, we collected duodenal/jejunal biopsy data on CD (equal to villous atrophy, Marsh stage 3, n=29 071 unique individuals) from (all) 28 pathology departments in Sweden. These individuals were compared with 144 429 reference individuals matched for age, sex, calendar year, and county. Data on DCM were obtained through the National Patient Register and confirmed by patient charts and echocardiography data. During follow-up, 17 patients with CD and 52 reference individuals developed idiopathic DCM. Thus, patients with CD were at an increased risk of idiopathic DCM (hazard ratio, 1.73; 95% confidence interval, 1.00 to 3.00), although the risk estimate failed to attain statistical significance (P=0.052).ConclusionThis nationwide study found a moderately but not statistically significantly increased risk of idiopathic DCM in patients with biopsy-verified CD. (J Am Heart Assoc. 2012;1:e001594 doi: 10.1161/JAHA.112.001594.)

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Section: Discussionmentioning

confidence: 61%

Risk of Idiopathic Dilated Cardiomyopathy in 29 000 Patients With Celiac Disease

Emilsson

Andersson

Elfström

et al. 2012

JAHA

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“…An increased incidence of dilated cardiomyopathy has been reported in CD patients [23–25]. Lodha et al [26] have reported a case of dilated cardiomyopathy with symptomatic CD. A study of 52 patients reported an incidence of 5.8% for coeliac disease in patients with dilated cardiomyopathy [27].…”

Section: Discussionmentioning

confidence: 99%

Subclinical Cardiac Dysfunction in Children with Coeliac Disease: Is the Gluten-Free Diet Effective?

Şaylan

Çevik

Kırşaçlıoğlu³

et al. 2012

ISRN Gastroenterology

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Objectives. The aim of this study is to investigate the effects of coeliac disease on cardiac function in children using conventional transthoracic echocardiography (TTE) and tissue Doppler echocardiography (TDE). Methods. Coeliac disease patients were evaluated in two different groups based on serum endomysial antibody (EmA) titers (EmA (+) and EmA (−)), and the data obtained by conventional and TDE studies were compared between the patient groups and healthy controls. Results. There was no significant difference between EmA (+) and EmA (−) groups in terms of the conventional TTE parameters, including ejection fraction (EF), fractional shortening (FS), and left ventricle end diastolic diameter (LVEDD), that show the left ventricular systolic function (P = 0.727, P = 0.317, P = 0.118). TDE showed a significant difference in left ventricle (LV) isovolumic relaxation time (LV IVRT) and LV myocardial performance index (LV MPI) parameters between EmA (+) and EmA (−) patient groups (P < 0.0001). Conclusion. The measurement of LV MPI and LV IVRT parameters by TDE would be beneficial in early determination of the cardiac involvement and establishing appropriate treatment and followup of patients with coeliac disease as well as in making distinction between EmA (+) and EmA (−) patients.

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“…Celiac disease (CD) is characterized by an immunologic response to gluten, which often results in diffuse inflammatory damage to the small intestinal mucosa, and malabsorption of nutrients[ 1 ]. CD is of special interest among chronic diseases due to several factors: (1) it is associated with specific comorbidities; (2) it involves a compromised absorption of nutrients; and (3) a gluten-free diet (GFD) is currently the main long-term treatment[ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Cardiovascular involvement in celiac disease

et al. 2017

WJC

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Celiac disease (CD) is an autoimmune response to ingestion of gluten protein, which is found in wheat, rye, and barley grains, and results in both small intestinal manifestations, including villous atrophy, as well as systemic manifestations. The main treatment for the disease is a gluten-free diet (GFD), which typically results in the restoration of the small intestinal villi, and restoration of other affected organ systems, to their normal functioning. In an increasing number of recently published studies, there has been great interest in the occurrence of alterations in the cardiovascular system in untreated CD. Herein, published studies in which CD and cardiovascular terms appear in the title of the study were reviewed. The publications were categorized into one of several types: (1) articles (including cohort and case-control studies); (2) reviews and meta-analyses; (3) case studies (one to three patient reports); (4) letters; (5) editorials; and (6) abstracts (used when no full-length work had been published). The studies were subdivided as either heart or vascular studies, and were further characterized by the particular condition that was evident in conjunction with CD. Publication information was determined using the Google Scholar search tool. For each publication, its type and year of publication were tabulated. Salient information from each article was then compiled. It was determined that there has been a sharp increase in the number of CD - cardiovascular studies since 2000. Most of the publications are either of the type “article” or “case study”. The largest number of documents published concerned CD in conjunction with cardiomyopathy (33 studies), and there have also been substantial numbers of studies published on CD and thrombosis (27), cardiovascular risk (17), atherosclerosis (13), stroke (12), arterial function (11), and ischemic heart disease (11). Based on the published research, it can be concluded that many types of cardiovascular issues can occur in untreated CD patients, but that most tend to resolve on a GFD, often in conjunction with the healing of small intestinal villous atrophy. However, in some cases the alterations are irreversible, underscoring the need for CD screening and treatment when cardiovascular issues arise of unknown etiology.

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Celiac Disease Associated with Dilated Cardiomyopathy

Cited by 11 publications

References 18 publications

Risk of Idiopathic Dilated Cardiomyopathy in 29 000 Patients With Celiac Disease

Risk of Idiopathic Dilated Cardiomyopathy in 29 000 Patients With Celiac Disease

Subclinical Cardiac Dysfunction in Children with Coeliac Disease: Is the Gluten-Free Diet Effective?

Cardiovascular involvement in celiac disease

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