Celiac disease as an autoimmune condition

Samaşcă, Gabriel; Sur, Genel; Lupan, Iulia; Tilincă, Mariana; Deleanu, Diana

doi:10.5114/ceji.2014.45954

Cited by 13 publications

(13 citation statements)

References 51 publications

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“…first-degree relatives, patients with Down's and Turner's syndrome, children with Dermatitis herpetiformis, IgA-deficiency, and autoimmune diseases. Regarding the latter group the association with CD is more evident for diabetes type 1 and autoimmune thyroid disease, but has also been reported for rheumatoid arthritis, Addison's disease, autoimmune hepatitis, and Sjögrens's syndrome (Gasbarrini 2014, Samasca 2014, Ludvisson 2015, Anania 2015. No causal association has however been found between those diseases and CD.…”

Section: High-risk Groupsmentioning

confidence: 89%

Demographics, clinical features and treatment of pediatric celiac disease

Tapsas¹

2015

Linköping University Medical Dissertations

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Celiac disease (CD) is a chronic small intestinal immune-mediated enteropathy triggered by ingestion of gluten-containing food in genetically predisposed subjects. The enteropathy is presented with a wide variety of clinical manifestations, which can occur even outside the gastrointestinal tract. In the majority of cases, the diagnosis of CD is based on a small intestinal biopsy showing mucosal alterations, i.e. intraepithelial lymphocytosis, crypt hyperplasia, and villous atrophy. The treatment, gluten-free diet (GFD), has recently been revised with the addition of gluten-free oats. Oats give a more diversified nutrition and increase the fibre content. The use of oats in CD is though still debated in some reports. A strict life-long adherence to the GFD can be problematic, especially for pediatric CD patients. Sweden reported of one of the highest observed CD prevalences worldwide, i.e. 3%, among 12-year-olds born during what has been described as "the Swedish celiac epidemic", 1984−1996.The aims of this thesis were to elucidate how pediatric CD has changed during a 41-year period in Sweden, i.e. 1973Sweden, i.e. −2013, in terms of clinical presentation, disease severity, incidence, and demographics. We also wanted to adress the compliance to the GFD, the use of oats in the GFD and the safety of oats inclusion in the diet by measuring urinary nitric oxide (NO) metabolites.Filed information provided data about 2856 pediatric patients investigated for suspected CD between 1973 and 2013; of which 1030 patients were diagnosed with CD. After the data analyses the mean age of CD patients was shown to increase after the celiac epidemic period.Currently, CD shows a less severe picture in terms of symptoms and intestinal pathology.Younger children suffer primarily from gastrointestinal symptoms and growth failure, whereas extra-intestinal manifestations are more often displayed among adolescents. viWe also reported an unusually high pediatric CD incidence rate and cumulative incidence, likely the highest reported worldwide. We hypothesised that the introduction of new antibody tests would affect the diagnostic activity and accuracy in performing small intestinal biopsies for CD investigation. However, the outcome of diagnostic activity and accuracy could not clearly be attributed to the use of antibody tests due to changes occurring in parallel during the 41-year study period, e.g. a different pattern of symptoms at presentation and improved knowledge of the disease among parents and health professionals.In a questionnaire-based study our patient group reported a high compliance to the GFD.Long duration of the GFD may, however, influence compliance negatively. Oats have been included to the GFD of our study population in most of the cases without reporting major complications related to their well-being.The urinary measurements of NO metabolites revealed two patient groups, one with high and one with low levels. The two populations did not differ regarding sex, age, compliance to the GFD or oats consumption. Fa...

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Section: High-risk Groupsmentioning

confidence: 89%

Demographics, clinical features and treatment of pediatric celiac disease

Tapsas¹

2015

Linköping University Medical Dissertations

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“…[13,14] As shown above, CD is a relative frequent pathological condition that needs a quick diagnosis in order to start the treatment. Because of the wide range of signs and symptoms, an accurate differential diagnosis is required [15,16]. So our goal was to make a current analysis of the differential diagnosis of CD.…”

Section: Prognosismentioning

confidence: 99%

Celiac Disease a Road Paved with Many Obstacles. Differential Diagnosis in Children

Sur¹,

Marius²,

Aldea³

et al. 2018

IJCD

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Celiac disease (CD), also known as gluten-sensitive enteropathy or celiac sprue, is defined as a chronic, multifactorial, immune-mediated condition affecting small intestine in genetically susceptible children and adults. Gluten-sensitive enteropathy is characterized by heterogeneous clinical manifestations of variable severity that can occur at any age. For patients with prompt diagnosis and correct treatment the prognosis is excellent. Therefore, CD needs a quick diagnosis in order to start the treatment. Because of the wide range of signs and symptoms, an accurate differential diagnosis is required.

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“…Diabetic ketoacidosis is a severe, potentially life-threatening complication of diabetes mellitus, characterized by elevated circulating ketones, and the development of ketoacidosis under hyperglycemic conditions due to insulin deficiency [5]. Especially type 1 diabetic patients are predisposed to ketoacidosis, in these cases an absolute insulin deficiency occurs on autoimmune background, the manifestation can be with or withour other associated diseases having similar mechanism [6]. According to recent statistics, Diabetic ketoacidosis can also occur in patients having type 2, secondary or other types of diabetes, triggered by infectious diseases, steroid medication or other states leading to shortage of insulin.…”

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confidence: 99%

Evaluation of Metabolic and Hydroelectrolytic Disturbances in Patients Diagnosed with Diabetic Ketoacidosis

Tilinca¹,

Nania²,

Pál³

et al. 2020

Rev. Chim.

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Ketoacidosis is a life-threatening complication of diabetes mellitus, especially type 1 diabetic patients being predisposed to this condition. Ketoacidosis might occur also in other types of diabetes triggered by circumstances leading to shortage of insulin. The aim of the study was the assessment of metabolic, hydroelectrolytic disturbances and the relationship between different parameters in patients hospitalized with diabetic ketoacidosis. We evaluated the clinical state, parameters of blood-gas analyzer, biochemistry and hematology laboratory results of 32 patients admitted with diabetic ketoacidosis between January-November 2018 at the Department of Diabetology, Nutrition and Metabolic Diseases of the Emergency County Hospital in T�rgu Mureș. Demographic data, associated diseases, body mass index were also evaluated. The considered threshold of significance was 0.05. The distribution of type 1 and 2 diabetes was 40.6 and 46.9% in the studied group, 53.1% being male patients. Positive correlation could be observed between pH and base excess and between pH and bicarbonate values, while negative correlation could be found between triglyceridemia and body mass index (BMI). Severe hyperglycemia, very low pH values, glucosuria, ketonuria and electrolytic imbalances were very common in the studied patients. Pancreatitis, respiratory tract and urinary infections could be found in the background of ketoacidotic manifestations in the majority of the patients, dehydration occured in each of the cases. Many severe metabolic and hydroelectrolytic disturbances could be observed in the studied patients presenting diabetic ketoacidosis. Infectious diseases are the most common triggers of metabolic imbalance in diabetic patients.

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Celiac disease as an autoimmune condition

Cited by 13 publications

References 51 publications

Demographics, clinical features and treatment of pediatric celiac disease

Demographics, clinical features and treatment of pediatric celiac disease

Celiac Disease a Road Paved with Many Obstacles. Differential Diagnosis in Children

Evaluation of Metabolic and Hydroelectrolytic Disturbances in Patients Diagnosed with Diabetic Ketoacidosis

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