Celiac Disease and the Autoimmune Web of Endocrinopathies

Sange, Ibrahim; Mohamed, Mohamed Wael F; Aung, Su May; Mereddy, Nakul; Hamid, Pousette

doi:10.7759/cureus.12383

Cited by 3 publications

(5 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As the age at diagnosis of diabetes decreases, the risk of CD increases, and children diagnosed with T1DM have a higher risk of developing CD, especially around the age of five. (31). In our study, the mean age at diagnosis of CD was 6.6 years, and the frequency of CD was 23.2% in patients with diabetes diagnosis of 5 years and younger, and 3.3% in patients with a diagnosis of more than 5 years.…”

Section: Discussionmentioning

confidence: 43%

“…CD and T1DM are autoimmune diseases that share common genetic variants and are both chronic, and similar to other autoimmune diseases, the combination of genetic susceptibility and environmental factors play a role in the formation of both diseases (31). Compared to the general population, the children with T1DM have 15 times more celiac serology positivity and up to 10 times more biopsy-proven CD.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Tip 1 Diabetes Mellitus Tanısı Alan Çocuk ve Ergenlerde Çölyak ve Otoimmün Tiroid Hastalıkları Sıklığının Belirlenmesi

KABA,

DEMİRBAŞ,

KENDİRCİ

2024

Medical Records

View full text Add to dashboard Cite

Objective: Celiac disease (CD) and autoimmune thyroid disease (AITD) are more common in individuals with Type 1 diabetes mellitus (T1DM) than in the general population. It is necessary for the patient to be able to screen, recognize and treat these diseases at an early stage. In our study, it was aimed to screen the frequency of children and adolescents with T1DM in terms of CD and AITD. Materials And Methods: The files of the patients who were followed up in our clinic with the diagnosis of T1DM between July 2015 and March 2022 were retrospectively analyzed. Age, gender, age at diagnosis, duration of T1DM, presence of antithyroid peroxidase (TPO Ab), antithyroglobulin (TG Ab) antibodies, and the concomitant autoimmune disease were investigated. Results: 199 patients with T1DM were included. Mean chronological age was 12.5±4.4 (2.5-21.3) years, mean diabetes duration was 4.0±3.5 (0.0-18.1), and 52.3% (n=104) of the study were female. While 84.9% (n=169) of the patients had no accompanying disease, 7.5% (n=15) had CD, 12.8% (n=25) had TPO Ab, 6.5% (n=13) had TG Ab, CD and AITH were present in 0.5% (n=1). While the frequency of CD is 23.2% (n=10), the presence of TPO Ab and TG Ab were 6.9% (n=3) in those with diabetes diagnosis younger than 5 years. Conclusıon: In accordance with the literature, the frequency of CD and AITD is higher in our patients with T1DM compared to the general population, the frequency of CD increases in patients with younger T1DM diagnosis, but the presence of thyroid antibodies occurs with advancing age at diagnosis, and both conditions are more common in females.

show abstract

Section: Discussionmentioning

confidence: 43%

Section: Discussionmentioning

confidence: 99%

Tip 1 Diabetes Mellitus Tanısı Alan Çocuk ve Ergenlerde Çölyak ve Otoimmün Tiroid Hastalıkları Sıklığının Belirlenmesi

KABA,

DEMİRBAŞ,

KENDİRCİ

2024

Medical Records

View full text Add to dashboard Cite

show abstract

“…Broadly speaking, specialized literature correlates CD with endocrinopathies such as diabetes, Hashimoto’s thyroiditis, Graves’ disease, Addison’s disease (adrenal insufficiency), secondary hyperparathyroidism, ovarian insufficiency or pituitary disorders (resulting in hypogonadism, prolactin level imbalances) ( 194 , 195 ). Autoimmune hemolytic anemia or autoimmune hepatitis can also be added to this list ( 196 ).…”

Section: Atypical Forms Of Celiac Diseasementioning

confidence: 99%

Celiac disease - a pluripathological model in pediatric practice

Lupu,

Sasaran,

Jechel

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

Being defined as an autoimmune, chronic pathology, frequently encountered in any age group, but especially in pediatrics, celiac disease (also called gluten enteropathy), is gaining more and more ground in terms of diagnosis, but also interest in research. The data from the literature of the last decades attest the chameleonic way of its presentation, there may be both classic onset symptoms and atypical symptoms. Given the impact played by celiac disease, especially in the optimal growth and development of children, the current narrative review aims to highlight the atypical presentation methods, intended to guide the clinician towards the inclusion of the pathology in the differential diagnosis scheme. To these we add the summary presentation of the general data and therapeutic lines regarding the underlying condition and the existing comorbidities. In order to place the related information up to date, we performed a literature review of the recent articles published in international databases. We bring forward the current theories and approaches regarding both classic celiac disease and its atypical manifestations. Among these we note mainly constitutional, skin or mucous, bone, neuro-psychic, renal, reproductive injuries, but also disorders of biological constants and association with multiple autoimmunities. Knowing and correlating them with celiac disease is the key to optimal management of patients, thus reducing the subsequent burden of the disease.

show abstract

“…При аутоімунних процесах мішенню для агресії імунної системи стають власні тканини материнського організму, і як результат, накопичення в організмі аутоантитіл, циркулювання яких ускладнює перебіг вагітності. З аутоімунних порушень, які спричиняються до репродуктивних втрат, загальновизнаними є, зокрема, антифосфоліпідний синдром, системний червоний вовчак та аутоімунний тиреоїдит [9].…”

unclassified

“…Генетично обумовлена схильність до целіакії окреслюється специфічним алельним поліморфізмом DQA1-та DQB1генів головного комплексу гістосумісності II класу. До 95 % пацієнтів з встановленою целіакією несуть DQ2.5 гетеродимер, що кодується DQA1*05 та DQB1*02 алелями, як в транс-, так і в цис-конфігурації (позиції), а у решти 5-10 % наявна молекула DQ8, що кодується DQB1*03:02 переважно в комбінації з DQA1*03 алельним варіантом [9,12]. При цьому слід на-голосити, що наявність у індивіда вищенаведених генотипів не передбачає однозначного розвитку хвороби, проте їх відсутність свідчить про майже 100 % виключення целіакії.…”

unclassified

The role of the HLA-complex genes in genesis of human idiopathic recurrent pregnancy loss

Terpyliak,

Zastavna,

Sosnina

et al. 2023

Fakt. eksp. evol. org.

View full text Add to dashboard Cite

Aim.To study the immunogenetic prerequisites of idiopathic recurrent spontaneous pregnancy losses in humans of allo- and autoimmune genesis. Methods. PCR-SSP (polymerase chain reaction with sequence-specific primers). Results. A comprehensive analysis of the distribution and frequency of allelic variants of the HLA-DRB1, HLA-DQA1, HLA-DQB1 genes testifies to an increased risk of recurrent pregnancy losses with a total homology of 50 % or more in couples and presence of the DQ2.5 genotype in a woman. The OR indicates that the risk of idiopathic recurrent spontaneous pregnancy loss increases 2.68 times when the homology of the couples is 50 % or more for two loci (HLA-DRB1, HLA-DQA1) and 12.8 times when the homology is 50 % or more for by three loci (HLA-DRB1, HLA-DQA1, HLA-DQB1), and if the DQ2.5 genotype is present in women, this risk increases 4 times. Conclusions. HLA genotyping of married couples with a history of spontaneous pregnancy loss is important for preconceptional prevention of recurrent pregnancy losses.

show abstract

Celiac Disease and the Autoimmune Web of Endocrinopathies

Cited by 3 publications

References 33 publications

Tip 1 Diabetes Mellitus Tanısı Alan Çocuk ve Ergenlerde Çölyak ve Otoimmün Tiroid Hastalıkları Sıklığının Belirlenmesi

Tip 1 Diabetes Mellitus Tanısı Alan Çocuk ve Ergenlerde Çölyak ve Otoimmün Tiroid Hastalıkları Sıklığının Belirlenmesi

Celiac disease - a pluripathological model in pediatric practice

The role of the HLA-complex genes in genesis of human idiopathic recurrent pregnancy loss

Contact Info

Product

Resources

About