Celiac Disease and Osteoporosis: A Review

Pérez-Castrillón, José-Luis; Andres-Calvo, Maria; Izquierdo-Delgado, Elena; Mendo, Marcelino; Luis, Daniel de; Dueñas‐Laita, Antonio

doi:10.2174/1876525400901010023

Cited by 2 publications

(3 citation statements)

References 31 publications

(25 reference statements)

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“…However, considering the high prevalence of CD (1%) and the modestly increased risk of fracture, densitometric studies of all celiac patients, as in menopausal women, are not considered cost-effective. [ 5 ] In the absence of evidence-based studies, densitometric studies can be done only in subgroups at high risk of fracture like non-compliant patients or those in whom a gluten-free diet has failed, patients treated with corticosteroids, hypogonadism, age older 70 years, BMI lower 20, and previous fragility fractures. [ 23 ] However, as CD may be silent, with osteoporosis as the first manifestation like in our patients, some authors suggest the need for celiac screening in all osteoporotic patients, or at least those who fail treatment.…”

Section: Discussionmentioning

confidence: 99%

“…[ 1 ] However, on many occasions, CD presents atypically with a predominance of extra-intestinal manifestations such as iron deficiency anemia, short stature,[ 2 3 ] recurrent stomatitis, bone pains, infertility, Graves’ disease, Type 1 diabetes mellitus,[ 4 ] and metabolic bone disease (MBD). [ 5 ]…”

Section: Introductionmentioning

confidence: 99%

“…CD may be associated with low bone mineral density (BMD) even in the absence of classical abdominal symptoms. [ 5 ] Osteoporosis was seen in 6.8% of the CD patients who had presented with extraintestinal manifestations. [ 6 ] Osteoporosis is usually a complication of most severe form of CD and it is uncommon to have MBD as the only presentation of CD.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Celiac disease: A missed cause of metabolic bone disease

Rastogi

Bhadada

Bhansali

et al. 2012

Indian J Endocr Metab

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Introduction:Celiac disease (CD) is a highly prevalent autoimmune disease. The symptoms of CD are varied and atypical, with many patients having no gastrointestinal symptoms. Metabolic bone disease (MBD) is a less recognized manifestation of CD associated with spectrum of musculoskeletal signs and symptoms, viz. bone pains, proximal muscle weakness, osteopenia, osteoporosis, and fracture. We here report five patients who presented with severe MBD as the only manifestation of CD.Materials and Methods:Records of 825 patients of CD diagnosed during 2002–2010 were retrospectively analyzed for clinical features, risk factors, signs, biochemical, and radiological parameters.Results:We were able to identify five patients (0.6%) of CD who had monosymptomatic presentation with musculoskeletal symptoms and signs in the form of bone pains, proximal myopathy, and fragility fractures without any gastrointestinal manifestation. All the five patients had severe MBD in the form of osteopenia, osteoporosis, and fragility fractures. Four of the five patients had additional risk factors such as antiepileptic drugs, chronic alcohol consumption, malnutrition, and associated vitamin D deficiency which might have contributed to the severity of MBD.Conclusion:Severe metabolic disease as the only presentation of CD is rare. Patients show significant improvement in clinical, biochemical, and radiological parameters with gluten-free diet, calcium, and vitamin D supplementation. CD should be looked for routinely in patients presenting with unexplained MBD.

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Section: Discussionmentioning

confidence: 99%