Celiac Disease and its Link to Type 1 Diabetes Mellitus

Schuppan, Detlef; Eg, Hahn

doi:10.1515/jpem.2001.14.s1.597

Cited by 47 publications

(40 citation statements)

References 14 publications

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“…Interestingly, there is a higher than normal incidence of overt coeliac disease in patients with T1D, with 2-10% (or more) of patients having histological evidence of gluten sensitive enteropathy. [12][13][14][15] In addition, approximately 10% of DQ2 homozygous T1D patients have circulatory IgA autoantibodies against tissue transglutaminase (tTG) 16 and a further 30% have circulating IgG anti-tTG autoantibodies. 17 Together with the fact that T1D and coeliac disease share overlapping susceptibility genes, 15 18 in particular the HLA DQB1*0201 allele, 19 these features are consistent with the idea that diet related immune responses in the gut could be important factors in the pathogenesis of diabetes.…”

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confidence: 99%

Enteropathy precedes type 1 diabetes in the BB rat

Graham

2004

Gut

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Background and aims: There is increasing evidence implicating intestinal immune responses to dietary proteins in the pathogenesis of type 1 autoimmune diabetes (T1D). Here we investigated the association between intestinal pathology and dietary factors in T1D by examining the mucosal architecture in the BB rat model. Methods: BB control (BBc) and diabetes prone (BBdp) rats were fed either a diabetes retardant hydrolysed casein based diet or one of two cereal based diets that promote the development of diabetes. Intestinal architecture was assessed in the jejunum by microdissection, histology, and immunohistology, and by measuring peroxidase activity and brush border invertase levels. Results: Enteropathy was present in BBdp rats soon after weaning, as assessed by increases in crypt length and in the proliferative activity of crypt epithelial cells in the jejunum, and this remained constant until 120 days of age. There was also a decrease in invertase activity, as well as increased numbers of intraepithelial lymphocytes, increased levels of mucosal peroxidase activity, and infiltration of the mucosa by CD4+ T lymphocytes. Equivalent enteropathy was present at all times in BBdp rats and was not influenced by the nature of the diet or by thymectomy at three weeks at age, procedures which prevent the development of diabetes. Conclusion: Enteropathy is a consistent feature in the diabetes prone BB rat but it precedes the onset of insulitis and appears to be due to mechanisms distinct from those which cause diabetes. The beneficial effects of the diabetes retardant hydrolysed casein diet on diabetes are not due to an effect on intestinal architecture per se but mucosal damage may be necessary for the development of autoreactivity in the pancreas.

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confidence: 99%

Enteropathy precedes type 1 diabetes in the BB rat

Graham

2004

Gut

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“…Three peptides of HSP70 are included, and T cell autoimmunity to HSP70 has been described in human type 1 diabetes patients (42). Gliadin is an antigen associated with celiac disease, and celiac patients have been reported to have an increased incidence of type 1 diabetes (43). myelin oligodendrocyte glycoprotein (MOG) is a molecule present in myelin, and T cell autoimmunity to MOG can induce experimental autoimmune encephalomyelitis in NOD mice (44).…”

Section: Discussionmentioning

confidence: 99%

Functional immunomics: Microarray analysis of IgG autoantibody repertoires predicts the future response of mice to induced diabetes

Quintana

Hagedorn

Elizur

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

144

139

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One's present repertoire of antibodies encodes the history of one's past immunological experience. Can the present autoantibody repertoire be consulted to predict resistance or susceptibility to the future development of an autoimmune disease? Here, we developed an antigen microarray chip and used bioinformatic analysis to study a model of type 1 diabetes developing in nonobese diabetic male mice in which the disease was accelerated and synchronized by exposing the mice to cyclophosphamide at 4 weeks of age. We obtained sera from 19 individual mice, treated the mice to induce cyclophosphamide-accelerated diabetes (CAD), and found, as expected, that 9 mice became severely diabetic, whereas 10 mice permanently resisted diabetes. We again obtained serum from each mouse after CAD induction. We then analyzed, by using rank-order and superparamagnetic clustering, the patterns of antibodies in individual mice to 266 different antigens spotted on the chip. A selected panel of 27 different antigens (10% of the array) revealed a pattern of IgG antibody reactivity in the pre-CAD sera that discriminated between the mice resistant or susceptible to CAD with 100% sensitivity and 82% specificity (P ‫؍‬ 0.017). Surprisingly, the set of IgG antibodies that was informative before CAD induction did not separate the resistant and susceptible groups after the onset of CAD; new antigens became critical for post-CAD repertoire discrimination. Thus, at least for a model disease, present antibody repertoires can predict future disease, predictive and diagnostic repertoires can differ, and decisive information about immune system behavior can be mined by bioinformatic technology. Repertoires matter.

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“…Celiac disease (CD) is characterized by impaired immunological response to ingested gluten, and 3 to 8 % of type 1 diabetes mellitus patients have CD [2]. Based on a recent metaanalysis, more than one in 20 patients with type 1 diabetes have biopsy-verified celiac disease [3].…”

Section: Introductionmentioning

confidence: 99%

Celiac crisis in an adult type 1 diabetes mellitus patient presented with diarrhea, weight loss and hypoglycemic attacks

Kızılgül

Kan

Çelik

et al. 2016

Int J Diabetes Dev Ctries

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Type 1 diabetes mellitus (T1DM) is an autoimmune disease, characterized by loss of the insulin-producing β cells of the islets of Langerhans in the pancreas, causing insulin deficiency. Celiac disease has been seen in 3 to 8 % of T1DM patients. Celiac crisis, an acute severe onset of celiac disease, is a rare and life-threatening manifestation. We report a 50-year-old man with type 1 diabetes mellitus who arrived at our service with a 2-month history of watery diarrhea associated with hypoglycemic attacks, abdominal pain, and weight loss of 13 kg. The diagnosis of celiac crisis was made based on diarrhea leading to dehydration, severe metabolic and electrolyte abnormalities, and subsequent improvement after introduction of a gluten-free diet.

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Celiac Disease and its Link to Type 1 Diabetes Mellitus

Cited by 47 publications

References 14 publications

Enteropathy precedes type 1 diabetes in the BB rat

Enteropathy precedes type 1 diabetes in the BB rat

Functional immunomics: Microarray analysis of IgG autoantibody repertoires predicts the future response of mice to induced diabetes

Celiac crisis in an adult type 1 diabetes mellitus patient presented with diarrhea, weight loss and hypoglycemic attacks

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