Celiac Disease and Gyneco-obstetrics Complications: Can Serum Antibodies Modulate Tissue Transglutaminase Functions and Contribute to Clinical Pattern?

Sóñora, Cecilia; Muñoz, Florencia; Río, Natalia Del; Acosta, Gisĕle; Montenegro, Cecilia; Trucco, Elena; Hernández, Ana

doi:10.1111/j.1600-0897.2011.01020.x

Cited by 11 publications

(14 citation statements)

References 48 publications

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“…This is the main step in the inflammatory pathogenic cascade that leads to the gut lesion . In addition, the extradigestive disorders are frequently observed in patients with CD and the aberrant expression and/or function of TG2 can also be implicated …”

Section: Discussionmentioning

confidence: 99%

“…The increased TG2 expression and TGase activity dysregulation is a common feature of several diseases; particularly, it is recognized as the central player molecule in the pathogenesis of coeliac disease (CD) . TG2 expression and activity is increased in the small intestine of patients with active disease; in addition, extradigestive TG2 dysfunction can contribute to extradigestive disorders . The inflammatory status of CD can be systemically reflected by the increase in various serological parameters; after long‐term adhesion to gluten‐free diet (GFD), these inflammatory parameters and specific serology declines in line with gradual gut mucosal recovery indicating that gluten triggers the disease …”

Section: Introductionmentioning

confidence: 99%

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Alternative RNA splicing of leucocyte tissue transglutaminase in coeliac disease

et al. 2018

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Tissue transglutaminase is a ubiquitous and multifunctional protein that contributes to several processes such as apoptosis/survival, efferocytosis, inflammation and tissue repairing under physiological and pathological conditions. Several activities can be associated with well-established functional domains; in addition, four RNA alternative splice variants have been described, characterized by sequence divergences and residues deletion at the C-terminal domains. Tissue transglutaminase is recognized as the central player in the physiopathology of coeliac disease (CD) mainly through calcium-dependent enzymatic activities. It can be hypothesized that differential regulation of tissue transglutaminase splice variants expression in persons with CD contributes to pathology by altering the protein functionality. We characterized the expression pattern of RNA alternative splice variants by RT-PCR in peripheral cells from patients with CD under free gluten diet adhesion; we considered inflammatory parameters and specific antibodies as markers of the stage of disease. We found significant higher expression of both the full length and the shortest C-truncated splice variants in leucocytes from patients with CD in comparison with healthy individuals. As tissue transglutaminase expression and canonical enzymatic activity are linked to inflammation, we studied the RNA expression of inflammatory cytokines in peripheral leucocytes of persons with CD in relation with splice variants expression; interestingly, we found that recently diagnosed patients showed significant correlation between both the full length and the shortest alternative spliced variants with IL-1 expression. Our results points that regulation of alternative splicing of tissue transglutaminase could account for the complex physiopathology of CD.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Alternative RNA splicing of leucocyte tissue transglutaminase in coeliac disease

et al. 2018

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“…This finding is somewhat intriguing, as CD has been reported to increase the risk for delayed menarche, amenorrhoea, early menopause, recurrent abortions and a reduced pregnancy rate , but not the risk for other menstrual abnormalities. The mechanisms underlying gynaecological complaints are unknown, although a report has suggested a putative involvement of tissue transglutaminase‐specific antibodies in gynaecological and obstetric disorders during active CD .…”

Section: Discussionmentioning

confidence: 99%

Large population study shows that adolescents with celiac disease have an increased risk of multiple autoimmune and nonautoimmune comorbidities

et al. 2017

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“…Another of the least performed studies for the diagnosis of CD is the immunoassay metric [40]; in this, the level of antigens and antibodies is measured and they use the serum endomysia antibody [1,19,20,22,33,35,37]. Different articles present that sensitivity to gluten or development of CD were related to a genetic factor.…”

Section: Characteristic Of the Included Studiesmentioning

confidence: 99%

Tools Used to Measure the Physical State of Women with Celiac Disease: A Review with a Systematic Approach

Martínez-Rodríguez

Loaiza-Martínez

Sánchez-Sánchez

et al. 2020

IJERPH

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Celiac disease (CD) is an immunological disorder that mainly affects the small intestine, generating an inflammatory process in response to the presence of gluten (a protein). Autoimmune diseases are part of a group of diseases that are difficult to diagnose without a specific protocol or consensus to detect them due to the number of symptoms and diseases with which it has a relationship. Therefore, the aim of this review was to analyze the diagnostic tools of CD used in middle-aged women, to compare the use and effectiveness of the different tools, and to propose a strategy for the use of the tools based on the results found in the literature. The present research followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline. The search was conducted in the following databases: Scielo, PubMed, Web of Science, and Worldwide Science org. In the initial literature search, 2004 titles and relevant abstracts were found. Among them, 687 were duplicates, leaving 1130 articles. Based on the inclusion criteria, only 41 articles passed the selection process; 4 main types of analyses appear in the studies: blood tests, questionnaires, clinical history, and biopsy. It can be said that none of the analyses have a 100% reliability since most of them can present false negatives; therefore, the best way to diagnose celiac disease up to now is through a combination of different tests (Immunoglobulin A and small intestinal biopsy).

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Celiac Disease and Gyneco-obstetrics Complications: Can Serum Antibodies Modulate Tissue Transglutaminase Functions and Contribute to Clinical Pattern?

Abstract: The significant correlation observed between serum effects and clinical profile suggests a putative involvement of tTG-specific antibodies in gynecological and/or obstetric disorders during active CD.

Cited by 11 publications

References 48 publications

Alternative RNA splicing of leucocyte tissue transglutaminase in coeliac disease

Alternative RNA splicing of leucocyte tissue transglutaminase in coeliac disease

Large population study shows that adolescents with celiac disease have an increased risk of multiple autoimmune and nonautoimmune comorbidities

Tools Used to Measure the Physical State of Women with Celiac Disease: A Review with a Systematic Approach

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