Celiac disease and fibromyalgia: Is there an association?

Nisihara, Renato; Marques, Ana Paula; Mei, A L; Skare, Thelma

doi:10.17235/reed.2015.3992/2015

Cited by 6 publications

(3 citation statements)

References 8 publications

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“…It has also been speculated that there is a correlation between CD, NCGS, and FM (7). Numerous studies have also shown that there is an alteration of the intestinal microbiome in IBS and FM patients (8). We know that the microbiome of the gut is strongly influenced by nutrition and that some foods, by modifying the intestinal bacterial flora in a proinflammatory sense, can worsen the clinical symptoms of some diseases, such as rheumatoid arthritis (9)(10)(11).…”

Section: N Introductionmentioning

confidence: 99%

Efficacy of a gluten-free diet in reducing the widespread pain index and symptom severity scale in patients affected by fibromyalgia

Bruzzese,

Marrese,

Scolieri

et al. 2023

Reumatismo

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Objective. Dietary interventions to improve fibromyalgia (FM) symptoms reported conflicting results. This study aimed to treat FM patients with a gluten-free diet (GFD), alternated with a non-restricted gluten-containing diet, followed by a rechallenge of the GFD. Methods. Twenty postmenopausal women with FM and no history of celiac disease participated. A GFD was assigned for 6 months. This was followed by 3 months of a non-restricted gluten-containing diet and then a new GFD for another 6 months. At each visit, the widespread pain index (WPI) and the symptom severity scale (SS) scores were evaluated. Results. The mean age of the patients enrolled was 53.9±10 years. None of the patients had a diagnosis of irritable bowel disease, although they reported vague gastrointestinal symptoms. After 6 months of a GFD, a statistically significant reduction was observed for the WPI (10.3±1.8 vs 7.7±1.4; p<0.0001) and the SS scale (6.4±1.8 vs 4.15±1.6; p=0.0002). The D percentage reduction of the WPI after 6 months of GFD was -24%±9%, while for the SS scale, it was -36%±21%. The following reintroduction of a gluten-containing diet brought about a statistically significant rise in the absolute SS scale and WPI, as well as a D modification of the WPI (21%±13%) and of the SS scale (74%±90%). The rechallenge of the GFD showed a significant improvement in absolute and D WPI (-24%±7%) and SS (-36%±11%). No modifications to the body mass index were found. Conclusions. A GFD improved FM symptoms evaluated with WPI and SS. This was confirmed for the first time, also with a rechallenge of the GFD that followed a non-restricted gluten-containing diet.

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Section: N Introductionmentioning

confidence: 99%

Efficacy of a gluten-free diet in reducing the widespread pain index and symptom severity scale in patients affected by fibromyalgia

Bruzzese,

Marrese,

Scolieri

et al. 2023

Reumatismo

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“…When positive diagnosis, the dietary therapy might improve not only the CD digestive symptoms, but also those related to fibromyalgia; however, data are still scarce [20]. There are also no data of an association, other than sporadic, between CD and fibromyalgia syndrome [21].…”

Section: Dear Editormentioning

confidence: 99%

Rheumatologic manifestations in celiac disease: what should we remember?

Dima

Jurcuţ²,

Jinga

2019

Romanian Journal of Internal Medicine

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“…In a study of 50 children with JFMS, only 1 had celiac disease and her pain level increased when on a gluten free diet [72]. While screening for celiac disease in all subjects with chronic widespread pain may not be feasible, patients may choose to undergo a trial of gluten-free diet in attempt to help alleviate their pain [73]. However, in an open-label randomized clinical trial comparing the effects of a gluten-free diet compared with a hypocaloric diet among adults with FMS, there was no difference between the two diets with regards to reducing the number of gluten sensitivity symptoms or secondary outcomes (sleep, anxiety, depression and overall well-being)[74].…”

Section: Non-pharmacological Managementmentioning

confidence: 99%

Fibromyalgia: Treating Pain in the Juvenile Patient

Gmuca

Sherry

2017

Pediatr Drugs

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Presently, evidence for the efficacy of medications for the treatment of juvenile fibromyalgia syndrome (JFMS) is limited. While there are medications approved by the US Food and Drug Administration (duloxetine, milnacipran and pregabalin) for adults with fibromyalgia syndrome, there are none for the treatment of JFMS. A variety of medications have been prescribed for the treatment of JFMS, including (but not limited to) non-opioid analgesics, opioids, anticonvulsants, antidepressants, and muscle relaxants. Psychological therapies, most prominently cognitive-behavioral therapy, are the most evidenced-based treatment modalities for JFMS. A multidisciplinary approach, combining pharmacological, behavioral and exercise-based modalities is currently the standard of care for JFMS. In the future, more stringent randomized, controlled trials with longer follow-up periods are needed in order to determine the long-term efficacy and safety of medications in the treatment of JFMS. Additionally, improved recognition of JFMS will allow for better patient recruitment to permit for adequately powered study designs.

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Celiac disease and fibromyalgia: Is there an association?

Cited by 6 publications

References 8 publications

Efficacy of a gluten-free diet in reducing the widespread pain index and symptom severity scale in patients affected by fibromyalgia

Efficacy of a gluten-free diet in reducing the widespread pain index and symptom severity scale in patients affected by fibromyalgia

Rheumatologic manifestations in celiac disease: what should we remember?

Fibromyalgia: Treating Pain in the Juvenile Patient

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