Celiac Crisis in the Modern Era

Mones, Richard L.; Atienza, Katherine; Youssef, Nader N.; Verga, Barbara; Mercer, Geraldine O; Rosh, Joel R.

doi:10.1097/mpg.0b013e318032c8e7

Cited by 32 publications

(25 citation statements)

References 16 publications

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“…In teen-agers the symptoms are often more subtle with anaemia (Mody et al, 2003), late puberty or short stature (Stenhammar et al, 1986). Some cases of childhood CD may present with an acute onset of diarrhoea, dehydration and severely affected general condition, so called celiac crisis (Mones et al, 2007). This severe condition may be induced by certain gastrointestinal virus infections.…”

Section: Symptoms Signs and Complicationsmentioning

confidence: 99%

Gut Microflora Associated Characteristics in Children with Celiac Disease

Tjellström

Stenhammar

Högberg

et al. 2005

Am J Gastroenterology

120

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All previously published papers were reproduced with permission from the publisher. ABSTRACT AimThe over-arching aim of this thesis was to study some metabolic functions of the gut microflora in children with known or screening detected celiac disease (CD) and their first-degree relatives. Materials Study I. A number of 36 untreated CD children, 47 after at least 3 months on glutenfree diet (GFD) and 42 healthy controls (HC). Study II. A number of 76 first-degree relatives to CD children and 93 healthy controls (HC). Study III. A number of 17 screening detected CD children were included to be compared with the untreated children and controls from study I; with exchange of one child in the untreated group, due to low age. Study IV. A comparative study regarding correlation between iso-forms of short chain fatty acids (SCFAs) in humans as well as in animals. Methods Faecal short chain fatty acids were measured in all four studies. Additionally faecal tryptic activity (FTA) was measured in study II. Major findingsAll groups of CD children demonstrated a similar SCFAs profile, i.e. significantly more total SCFAs and acetic acid and a strong tendency to more iso-butyric and iso-valeric acids compared with HC. The first-degree relatives demonstrated another SCFAs profile, i.e. significantly less total SCFAs and acetic acid and significantly more FTA than HC. Conclusions and future outlookBased upon the strong similarities between all groups of CD children we are allowing ourselves hypothesising that CD children have a "celiacogenic" flora compared with healthy controls. In a similar way it can be said that the first-degree relatives are harbouring a "celiacprotective" microflora. Our findings open up for challenging new diagnostic, therapeutic and prognostic possibilities.

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Section: Symptoms Signs and Complicationsmentioning

confidence: 99%

Gut Microflora Associated Characteristics in Children with Celiac Disease

Tjellström

Stenhammar

Högberg

et al. 2005

Am J Gastroenterology

120

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“…This may be the result of natural selection (13). It has also been hypothesized that factors such as the increased incidence of breast-feeding, the delayed introduction of baby food in general, and the introduction of glutencontaining cereals at an older age have contributed to the changing nature of CD (13). In conclusion, in some patients, the lesions of CD may be extensive and may therefore result in more severe symptoms.…”

Section: Discussionmentioning

confidence: 99%

“…It may be because of the changing nature of CD in general (ie, toward a more subtle and indolent disease). This may be the result of natural selection (13). It has also been hypothesized that factors such as the increased incidence of breast-feeding, the delayed introduction of baby food in general, and the introduction of glutencontaining cereals at an older age have contributed to the changing nature of CD (13).…”

Section: Discussionmentioning

confidence: 99%

Celiac Disease with Celiac Crisis

et al. 2010

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“…(1,8,9). Celiac crisis is a life-threatening complication of celiac disease, and can be exacerbated in patients with diabetes mellitus (2,10).…”

Section: Discussionmentioning

confidence: 99%

Celiac crisis in an adult type 1 diabetes mellitus patient: a rare manifestation of celiac disease

Toyoshima

Queiroz

Silva

et al. 2013

Arq Bras Endocrinol Metab

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SUMMARYCeliac crisis, an acute severe onset of celiac disease, is a rare and life-threatening manifestation. We report a 30-year-old woman with type 1 diabetes mellitus who arrived at our service with one-month history of severe acute watery diarrhea associated with nausea, vomiting, abdominal pain, and weight loss of 9 kg. The diagnostic hypothesis of celiac crisis was reached based on profuse diarrhea leading to dehydration, severe metabolic and electrolyte abnormalities, and subsequent improvement after introduction of a gluten-free diet. Arq Bras Endocrinol Metab. 2013;57(8):650-2

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Celiac Crisis in the Modern Era

Cited by 32 publications

References 16 publications

Gut Microflora Associated Characteristics in Children with Celiac Disease

Gut Microflora Associated Characteristics in Children with Celiac Disease

Celiac Disease with Celiac Crisis

Celiac crisis in an adult type 1 diabetes mellitus patient: a rare manifestation of celiac disease

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