Celiac Crisis Associated with Herpes Simplex Virus Esophagitis

Chen, Alan; Linz, Christopher; Tsay, Julie; Jin, Ming; El-Dika, Samer

doi:10.14309/crj.2016.132

Cited by 5 publications

(1 citation statement)

References 8 publications

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“…It is not straightforward to associate coeliac disease with hepatitis C [20], even if there can be a connection by means of HLA-DQ2, a secondary pathway with Sjogren's syndrome, or an amino-acid sequence homologous to a gliadin epitope. In [21], herpes simplex has a cooccurence in a patient with CD, but the correlation is not claimed in term of causality: probably the malabsorption of the nutrients is the trigger for a sort of immunodeficiency. A direct relationship between CD and measles is lacking in scientific literature, but pathway analysis and PPI network have highlighted common functional annotations between measles and rheumatoid arthritis, that is cytokine-cytokine receptor interaction, Jak-STAT signalling, T cell receptor signalling, and cell adhesion molecules [22], and all of them are involved in CD.…”

Section: Common Evidences Among Coeliac Disease and Comorbiditiesmentioning

confidence: 99%

Reusing microarray clinical data from a complex disease with bioinformatics tool

Prete

Facchiano

Lió

2018

Preprint

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Clinical bioinformatics, translational bioinformatics and personalised medicine are connected by the common task of analysing and integrating clinical data and results, in order to find important biomarkers related to pathologies and facilitate their prediction, diagnosis and treatment. New technologies provides the possibility to have more and more clinical data available in online databases. This data can be reused for studying complex disease from novel point of views. This work show how it is possible considering online microarray data from coeliac disease and some of its comorbidities, combining both the data and the results. The main goal is the extraction of common evidences among the selected pathologies, from genes to different kinds of functional annotation, showing which biological processes are more involved in these autoimmune disorders and quantifying the similarity between coeliac disease and its comorbidities. The pipeline of the work is developed in R language, and it is semi-automated. Methodologically, the advantage of this work is the possibility of performing the entire analysis starting from a different pathology; clinically, scientists can have the possibility of using data already published to highlight old and new evidences, with the possibility of improve the knowledge on a complex disease according to the availability of new microarray data.

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Section: Common Evidences Among Coeliac Disease and Comorbiditiesmentioning

confidence: 99%

Reusing microarray clinical data from a complex disease with bioinformatics tool

Prete

Facchiano

Lió

2018

Preprint

View full text Add to dashboard Cite

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Celiac Crisis

Zeitz¹,

Green²

2020

Diagnosis and Management of Gluten-Associated Disorders

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Life-threatening onset of coeliac disease: a case report and literature review

Guarino

Gambuti

Alfano

et al. 2020

BMJ Open Gastroenterol

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BackgroundCoeliac disease (CD) results from an immune-mediated reaction to gluten in genetically predisposed individuals. In rare cases CD may occur with acute features deferring the diagnosis and exposing these patients to possible life-threatening complications. Herein we present the case of a young woman with a coeliac crisis, that is, a sudden clinical onset characterised by severe electrolyte imbalance due to an unknown (previously unrecognised) CD.MethodsThis is a case report and literature review revealing that coeliac crisis is under-reported, with a total of 48 adult cases so far published. The diagnosis in our case was established by histopathological analysis of multiple duodenal biopsies. The patient’s serum was tested by enzyme-linked immunoassay to detect antitransglutaminase IgA antibodies.ResultsIn contrast to cases reported in the literature, with male gender predominance and a mean age of 50±17 years, our patient was a young female case of coeliac crisis. However, like in our patient, a higher incidence of coeliac crisis was associated with the human leucocyte antigen (HLA)-DQ2 haplotype, versus HLA-DQ8, and a severe (Marsh-Oberhüber 3c) duodenal mucosa atrophy. Notably, there is no clear correlation between the antitissue transglutaminase 2 IgA antibody titre and coeliac crisis onset/severity, as confirmed by our case report.ConclusionsThe present case highlights that CD may manifest quite abruptly with a severe malabsorption syndrome, that is, electrolyte abnormalities and hypoproteinaemia. Our case should alert physicians, in particular those in the emergency setting, that even a typically chronic disorder, such as CD, may show life-threatening complications requiring urgent management.

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Celiac Crisis Associated with Herpes Simplex Virus Esophagitis

Cited by 5 publications

References 8 publications

Reusing microarray clinical data from a complex disease with bioinformatics tool

Reusing microarray clinical data from a complex disease with bioinformatics tool

Celiac Crisis

Life-threatening onset of coeliac disease: a case report and literature review

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