Celery-dependent exercise-induced anaphylaxis

Silverstein, Steven R.; Frommer, David A.; Dobozin, Bruce S.; Rosén, Peter

doi:10.1016/0736-4679(86)90040-5

Cited by 47 publications

(20 citation statements)

References 22 publications

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“…This is compatible with the data reported by DuPont et al (23) in which repeats of QQXP, QQQXP, or QQQQXP (X ϭ F, I, and L in order of predominance) are characteristic for the -5-type gliadins. We further determined that the critical amino acids in the QQIPQQQ and QQFPQQQ epitopes were positions Gln 1 , Pro 4 , Gln 5 , Gln 6 , and Gln 7 , suggesting the epitope sequence QXX-PQQQ. In addition, it was speculated that the glutamine residue in the epitope sequence could be replaced by glutamic acid without loss of allergenic ability because both QQSPQQQ and QQSPEQQ epitopes were recognized equally.…”

Section: Discussionmentioning

confidence: 97%

“…4. No binding of the serum IgE was observed when the alanine was substituted at the amino acid positions Gln 1 , Pro 4 , Gln 5 , Gln 6 , and Gln 7 , respectively, indicating that these amino acids are critical for IgE binding in both epitopes. The remaining sera of the three patients were analyzed in the same manner, and the critical amino acids for IgE-binding were found to be the same as in patient 1 (data not shown).…”

Section: Ige Binding Epitope In -5mentioning

confidence: 99%

“…Food items such as shrimp (2), hazelnut (3), buckwheat (4), corn (5), and celery (6) are responsible for the development of food-dependent exercise-induced anaphylaxis. However, of all of the various kinds of food, wheat is reported to be the allergen with the highest frequency in Japan (7).…”

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confidence: 99%

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Identification of the IgE-binding Epitope in ω-5 Gliadin, a Major Allergen in Wheat-dependent Exercise-induced Anaphylaxis

Matsuo

Morita

Tatham

et al. 2004

Journal of Biological Chemistry

166

186

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Wheat-dependent exercise-induced anaphylaxis (WDEIA) is a severe IgE-mediated allergic reaction provoked by the combination of wheat-ingestion with intensive physical exercise over the next few hours. Among wheat proteins, -5 gliadin, which is one of the components of fast -gliadin, has been reported as a major allergen in the anaphylaxis. In this study, we detected IgE-binding epitopes within the primary sequence of -5 gliadin using arrays of overlapping peptides synthesized on derivatized cellulose membranes. Sera from four patients with WDEIA having specific IgE to the fast -gliadin were used to probe the membrane. Seven epitopes, QQIPQQQ, QQLPQQQ, QQFPQQQ, QQSPEQQ, QQSPQQQ, QQYPQQQ, and PYPP, were detected within the primary sequence of -5 gliadin. By using sera of 15 patients, 4 of them, QQIPQQQ, QQFPQQQ, QQSPEQQ, and QQSPQQQ, were found to be dominant epitopes. Mutational analysis of the QQIPQQQ and QQFPQQQ indicated that amino acids at positions Gln 1 , Pro 4 , Gln 5 , Gln 6 , and Gln 7 were critical for IgE binding. These results will provide a useful tool for developing safer wheat products in addition to diagnostic and immunotherapy techniques for WDEIA.Food-dependent exercise-induced anaphylaxis is a distinct form of food allergy induced by physical exercise (1). Food items such as shrimp (2), hazelnut (3), buckwheat (4), corn (5), and celery (6) are responsible for the development of food-dependent exercise-induced anaphylaxis. However, of all of the various kinds of food, wheat is reported to be the allergen with the highest frequency in Japan (7). Symptoms are typically generalized urticaria and severe allergic reactions such as shock or hypotension. Because of this serious reaction, it is important to determine the causative food to avoid the allergic reaction. A challenge test consisting of ingestion of the assumed food followed by intense physical exercise is the only reliable method to determine the causative food and to diagnose the disease. However, the challenge test is not always safe because in some cases the test induces an anaphylactic shock. In addition, the most reliable treatment for this disease is to avoid taking the causative food or, alternatively, to take a rest after meals. However, in the case of wheat allergy, elimination causes a decline in the quality of life for the patients. Thus, an in vitro diagnostic method as well as hypoallergenic wheat is necessary for patients with wheat-dependent exercise-induced anaphylaxis (WDEIA). 1Recent studies have revealed the IgE-binding epitopes of several food allergens including egg (8), milk (9, 10), soybean (11), and peanut (12), whereas the IgE-binding epitopes for wheat allergen are controversial. Wheat protein is composed of water/salt-soluble proteins and water/salt-insoluble proteins. Proteins in the water/salt-soluble fraction, such as ␣-amylase inhibitor, peroxidase, glycerinaldehyde-3-phosphate dehydrogenase, serpin, and triosephosphate isomerase, have been considered to be major allergens in patients with bakers' asthma (13-15...

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Section: Discussionmentioning

confidence: 97%

Section: Ige Binding Epitope In -5mentioning

confidence: 99%

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Identification of the IgE-binding Epitope in ω-5 Gliadin, a Major Allergen in Wheat-dependent Exercise-induced Anaphylaxis

Matsuo

Morita

Tatham

et al. 2004

Journal of Biological Chemistry

166

186

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“…These include shellfish [2,14,17,19,21], wheat products [4,14,[15][16][17][18][19][20], vegetables [3,14,22,23], fruits [14,17,24], nuts [14], egg [14,25], mushrooms [26], corn [14,27], garlic [14], meat including pork/beef [14], and rice [14]. In European countries, vegetables are the most common food allergens.…”

Section: Causative Foodsmentioning

confidence: 99%

Food-dependent exercise-induced anaphylaxis

Morita,

Kunie,

Matsuo

2007

Journal of Dermatological Science

189

140

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“…Los alimentos más frecuentemente implicados son de origen vegetal, y entre éstos destacan los cereales (fundamentalmente el trigo) (16,17,21,(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38), las frutas frescas (16,17,39,40) y los frutos secos (33,34,41,42). Se han descrito casos relacionados con distintos tipos de verduras y especias (7,17,21,34,(43)(44)(45) (3,16,47,48). Existen casos puntuales de reacciones consecutivas a la ingesta de huevo (48,49), leche de vaca (50) o moluscos cefalópodos (51).…”

Section: Etiopatogeniaunclassified

Síndrome de anafilaxia inducida por ejercicio

Pimiento

Parra

Montoya

et al. 2001

An. Med. Interna (Madrid)

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INTRODUCCIÓNEl incremento gradual de las prácticas deportivas en la sociedad actual, junto con la alta prevalencia de la patología alérgica en los sectores de la población con mayor actividad física, ha supuesto la aparición de síndromes de trasfondo alérgico, en ocasiones subclínicos, que sólo se manifiestan con el ejercicio (1,2) (Tabla I). Entre estos cuadros clínicos destaca por su potencial gravedad la anafilaxia inducida por ejercicio (AIE), que constituye una forma peculiar de anafilaxia conocida desde hace tan sólo dos décadas pero que se observa cada vez con mayor frecuencia.La anafilaxia inducida por ejercicio (AIE) fue descrita por primera vez por Maulitz en 1979 (3) en un corredor de fondo que sufría reacciones anafilácticas recurrentes de intensidad variable al practicar ejercicio tras la ingestión de marisco.Poco después, Sheffer y Austen (4) establecerían sus características definitorias, considerándola como una forma de alergia física severa que puede ser provocada por cualquier tipo 49 [0212-7199(2001) RESUMENEn las dos últimas décadas se ha observado una incidencia creciente de una forma peculiar de anafilaxia que sólo se produce al realizar ejercicio físico. Dentro del síndrome de anafilaxia inducida por ejercicio se incluyen dos formas clínicas bien diferenciadas: urticaria colinérgica sistémica y anafilaxia inducida por ejercicio propiamente dicha, que se puede presentar en su forma clásica o en su forma variante, más infrecuente y con manifestaciones similares a la urticaria colinérgica. La anafilaxia postprandial inducida por ejercicio o dependiente de alimentos constituye un subtipo frecuentemente identificado en estos últimos casos. Puede deberse a una alergia alimentaria subclínica que se manifiesta con el esfuerzo, aunque en muchas ocasiones no es posible encontrar un alergeno responsable. El diagnóstico se establece por la historia clínica y la realización de pruebas específicas con alergenos alimentarios. Puede ser necesario recurrir a una prueba de esfuerzo con y sin ingesta previa. El tratamiento es preventivo y se basa en evitar la comida o el alimento responsable de la alergia en las horas previas a la realización del ejercicio. Cuando no depende de alimentos se recurre a farmacoterapia profiláctica con antihistamínicos, cromonas o bicarbonato sódico. El paciente debe ser instruido sobre el uso de adrenalina en caso de nuevas reacciones.PALABRAS CLAVE: Anafilaxia inducida por ejercicio. Anafilaxia inducida por ejercicio dependiente de alimentos. Hipersensibilidad alimentaria. ABSTRACTIn

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Celery-dependent exercise-induced anaphylaxis

Cited by 47 publications

References 22 publications

Identification of the IgE-binding Epitope in ω-5 Gliadin, a Major Allergen in Wheat-dependent Exercise-induced Anaphylaxis

Identification of the IgE-binding Epitope in ω-5 Gliadin, a Major Allergen in Wheat-dependent Exercise-induced Anaphylaxis

Food-dependent exercise-induced anaphylaxis

Síndrome de anafilaxia inducida por ejercicio

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