“…The role of GI prophylaxis for selective NSAIDs has been considered an important avenue of research, but until recently there were few studies to guide therapeutic decision making (110). A review of 5 strategies to prevent NSAID-induced GI toxicity found that misoprostol, selective NSAIDs, and PPIs all reduced the risk of symptomatic ulcers; however, standard-dose H 2 receptor antagonists did not (111).…”