Celecoxib and melatonin in prevention of female rat mammary carcinogenesis

Orendáš, Peter; Kassayová, Monika; Kajo, Karol; Ahlers, I; Kubatka, Peter; Bojková, Bianka; M, Péc; Ahlersová, E

doi:10.4149/neo_2009_03_252

Cited by 14 publications

(11 citation statements)

References 16 publications

(25 reference statements)

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“…Abou-Issa et al (2001) reported inhibition in DMBA-induced mammary carcinogenesis in female Sprague-Dawley rats by celecoxib (0.25 g kg −1 , 0.50 g kg −1 , 1.00 g kg −1 or 1.50 g kg −1 diet) administered with diet. Similar results yielded our group -decrease in tumor incidence and frequency per animal and group was found during 20-week administration of celecoxib (1.67 g kg −1 chow) in NMUinduced mammary carcinogenesis; co-administration of melatonin reinforced the effect of celecoxib (Orendáš et al 2009). …”

Section: Discussionsupporting

confidence: 71%

“…Our group proved the chemopreventive effects of indomethacin administered in drinking water (Môci-ková-Kalická et al 2001), nimesulide applied subcutaneously (Kubatka et al 2002), rofecoxib (Kubatka et al 2003), etoricoxib (Orendáš et al 2007), and celecoxib (Orendáš et al 2009), all administered in the diet to female Sprague-Dawley rats with chemically-induced mammary tumors. Generally, at least 90% of mammary tumors showed malignant features, cribriform carcinoma in situ and invasive adenocarcinomas prevailed; the malignant/benign tumor ratio maintained regardless of oncostatic efficacy (Orendáš et al 2009).…”

Section: Introductionmentioning

confidence: 99%

“…Generally, at least 90% of mammary tumors showed malignant features, cribriform carcinoma in situ and invasive adenocarcinomas prevailed; the malignant/benign tumor ratio maintained regardless of oncostatic efficacy (Orendáš et al 2009). …”

Section: Introductionmentioning

confidence: 99%

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Chemopreventive effect of diclofenac on mammary carcinogenesis in Sprague-Dawley rats

et al. 2013

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Chemopreventive effect of non-steroidal antiinflammatory drugs (NSAIDs) in mammary carcinogenesis was reported in several studies. In this study, the effect of a nonselective cyclooxygenase inhibitor diclofenac (DICLO) in the prevention of N-methyl-N-nitrosourea (NMU)-induced mammary carcinogenesis in Sprague-Dawley female rats was evaluated. NMU was administered to animals intraperitoneally in two doses of 50 mg kg −1 b.w. within postnatal days 42-48. In experiment A (short-term administration), DICLO was administrated intramuscularly (5 mg kg −1 b.w.) every other day, starting 3 days before and for subsequent 25 days after first NMU injection. In experiment B (long-term administration), DICLO was administered in tap water (0.01 mg ml −1 ) continually, starting 7 days before and for subsequent 22 weeks after first NMU dose. The study was terminated 22 weeks after the first dose of NMU in both experiments. After DICLO treatment, tumor frequency per group was reduced in both variants of drug administration: in experiment A by 38% and in experiment B by 39.5%. Moreover, DICLO decreased tumor incidence by 11.5% and delayed tumor latency by 14 days in experiment B. In our preventive-curative experiments DICLO decreased some parameters of NMU-induced rat mammary carcinogenesis, mainly the tumor frequency.

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Section: Discussionsupporting

confidence: 71%

Section: Introductionmentioning

confidence: 99%

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Chemopreventive effect of diclofenac on mammary carcinogenesis in Sprague-Dawley rats

et al. 2013

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“…Previously, we found a single long-term administration of PIO (Bojková et al, 2010) and MT to decrease mammary tumour incidence and frequency; PIO also positively altered tumour histopathological profile (Bojková et al, 2010). MT enhanced the mammary tumour growth inhibition of other substances: retinoids Bojková et al, 2000;Orendáš et al, 2012), NSAIDs (Kubatka et al, 2002;Orendáš et al, 2009), selective oestrogen-receptor modulators (Kubatka et al, 2001a(Kubatka et al, , 2001b and resveratrol (Kisková et al, 2012). In all these experiments, however, a standard-type diet was used (3-4% of total fat).…”

Section: Discussionmentioning

confidence: 94%

Role of high-fat diet on the effect of pioglitazone and melatonin in a rat model of breast cancer

Bojková

Orendáš

Kajo

et al. 2016

European Journal of Cancer Prevention

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The risk of cancer may be modulated by drugs with pleiotropic effects and diet has been implicated in the efficacy of treatment. The oncopreventive effects of the antidiabetic drug pioglitazone (PIO) and the anti-insomnia drug melatonin (MT), in vivo, have been proven before, but using a standard-type diet. This study evaluated the impact of a high-fat diet on their efficacy in chemically induced mammary carcinogenesis in Sprague-Dawley rats. Mammary tumours were induced by N-methyl-N-nitrosourea (50 mg/kg, intraperitoneal, on the 41st postnatal day). PIO and MT administration was initiated 11 days before the carcinogen application and lasted until the termination of the experiment at 16 weeks. PIO was administered in a diet (10% fat) at a concentration of 100 ppm and MT was administered in tap water (20 mg/l). PIO, MT and the combination did not significantly alter the basic tumour growth parameters. However, histopathology showed a decrease in the high-grade/low-grade tumour ratio, particularly in animals that received combined treatment (P<0.01). Semiquantitative immunohistochemistry indicated the proapoptotic effect of chemoprevention, particularly in the drug combination group (P<0.01), but no changes in tumour cell proliferation and angiogenesis were recorded. Results were evaluated by one-way analysis of variance or the Mann-Whitney U-test, respectively. PIO and MT, alone or in combination, administered to rats fed a high-fat diet reduced the proportion of high-grade tumours and promoted apoptosis in an in-vivo breast cancer model, although it did not suppress tumour growth. The impact of high dietary fat content on the chemopreventive efficacy of these and other substances should be considered in human studies.

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“…The anticancer effects of various chemopreventive agents [1][2][3][4][5][6]or their combinations with chemotherapeutic drugs [7][8][9][10][11] have been studied extensively.…”

mentioning

confidence: 99%

Synthetic isothiocyanate indole-3-ethyl isothiocyanate (homoITC) enhances sensitivity of human ovarian carcinoma cell lines A2780 and A2780/CP to cisplatin

Stehlik

Paulíková²,

Hunáková³

2010

neo

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Isothiocyanates (ITCs), popular chemopreventive agents present in cruciferous vegetables, prove growth-inhibiting and apoptosis-inducing activities in cancer cell lines in vitro. Our study presents a new synthetic ITC derivate indol-3-ethyl isothiocyanate (homoITC) as an effective modulator of cellular proliferation and inducer of apoptosis with potential utility as an anticancer drug or a sensitizer to routinely used chemotherapeutic agent cisplatin (cis-Pt).We analyzed the growth inhibitory effects of homoITC in the human ovarian carcinoma cell line A2780 and its cisplatinresistant variant A2780/CP using MTT-test and its apoptosis-inducing properties by flow cytometry and caspase 3 activation. Combination index (CI) values from Calcusyn software were used to characterize the interactions of homoITC and cis-Pt as synergistic (CI<1), additive (CI=1), or antagonistic (CI>1). Significant synergistic effect in growth inhibition of homoITC (5 -15 µM) and cis-Pt (2.5 -10 µM) on A2780 parental cell line (CI from 0.42 to 0.85) was also observed on A2780/CP resistant subline (CI from 0.18 to 0.73) for 10-50 µM cis-Pt concentrations and the same concentrations of homoITC. Synergy in growth inhibition correlated with the potential of homoITC to stimulate apoptosis induced by cis-Pt.We conclude that homoITC may be worth of further studies assessing its value in the ovarian cancer treatment and elucidating mechanisms of its action.

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Celecoxib and melatonin in prevention of female rat mammary carcinogenesis

Cited by 14 publications

References 16 publications

Chemopreventive effect of diclofenac on mammary carcinogenesis in Sprague-Dawley rats

Chemopreventive effect of diclofenac on mammary carcinogenesis in Sprague-Dawley rats

Role of high-fat diet on the effect of pioglitazone and melatonin in a rat model of breast cancer

Synthetic isothiocyanate indole-3-ethyl isothiocyanate (homoITC) enhances sensitivity of human ovarian carcinoma cell lines A2780 and A2780/CP to cisplatin

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