Celecoxib, a cyclooxygenase-2 inhibitor, offers chemoprevention against reproductive and neurobehavioural abnormalities induced by atrazine in male Wistar rats

Developmental Exposure to Atrazine Impairs Spatial Memory and Downregulates the Hippocampal D1 Dopamine Receptor and cAMP-Dependent Signaling Pathway in Rats

“…The same effect was also found even at a low concentration of ATR (3 mg/L) in dams and adult female C57BL/6 mice [16]. Moreover, exposure of male Wistar rats to ATR at 300 mg/kg BW for 7 days decreased performance in the Y-maze spontaneous alternation test [17]. …”

Subacute and subchronic oral toxicity assessments of Acridocarpus smeathmannii (DC.) Guill. & Perr. root in Wistar rats

“…Safety testing is needed in order to popularize acceptance, standardize and/or regulate the market of herbal medicines currently being offered [9]. However, in recent times, scientists have inquire into scrutinizing the quantity and quality of the safety and efficacy potential acclaimed in folklore medicine in order to provide data to meet the criteria needed to support its use worldwide [[28], [29], [30], [31]].…”

“…Toxicity testing can be used to obtain information on the biologic activity of a chemical substance and gain insight into its mechanisms of action [30,32,31]. More so, toxicological evaluation studies are important aspects of drug development and for the extension of their therapeutic potentials [[8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31]]. Thus, it helps pinpoint information on the adverse reactions which are potentially relevant to the substance being evaluated [33].…”

“…Weight modulation is a very vital characteristic of several medicinal agents [28,30,31]. Here, we explored further the organ weight to body weight ratio.…”

“…In addition, we estimated cyclooxygenase (COX), a rate-limiting enzyme in the metabolism of arachidonic acid to prostanoids [46]. COX-2 is expressed at the site of inflammation or induced by cytokines, growth factors, and hormones [30,31]. Homeostatic functions and the pathological roles played by COX-2 have been well established [30,46,31].…”