Celebrating Two Centuries of Research in Selenium Chemistry: State of the Art and New Prospective

Santi, Claudio; Bagnoli, Luana

doi:10.3390/molecules22122124

Cited by 30 publications

(14 citation statements)

References 18 publications

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“…Selenium was discovered by Berzelius in 1817, which plays vital roles in humans with functions in preventing cancer, boosting immunity, detoxifying cells, and even in combatting COVID-19 infections (Santi and Bagnoli, 2017 ; Moghaddam et al, 2020 ; Zhang et al, 2020 ). Selenium is generally beneficial for plants in appropriate concentrations and has been found to influence photosynthesis (Jiang et al, 2017 ), root architecture (Zhao et al, 2019 ), senescence (Hajiboland et al, 2019 ), vegetable quality (Mckenzie et al, 2019 ), defense, and stress response (Alves et al, 2020 ; Wen, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Melatonin Participates in Selenium-Enhanced Cold Tolerance of Cucumber Seedlings

et al. 2021

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Melatonin is an important and widespread plant hormone. However, the underlying physiological and molecular mechanisms of melatonin as a secondary messenger in improving cold tolerance by selenium are limited. This study investigated the effects of selenite on the cold stress of cucumber seedlings. The results showed that exogenous application of selenite improved the cold tolerance of cucumber seedlings, which was dependent on the concentration effect. In the present experiment, 1 μM of selenite showed the best effect on alleviating cold stress. Interestingly, we found that in the process of alleviating cold stress, selenite increased the content of endogenous melatonin by regulating the expression of melatonin biosynthesis genes (TDC, T5H, SNAT, and COMT). To determine the interrelation between selenite and melatonin in alleviating cold stress, melatonin synthesis inhibitor p-chlorophenylalanine and melatonin were used for in-depth study. This study provides a theoretical basis for cucumber cultivation and breeding.

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Section: Introductionmentioning

confidence: 99%

Melatonin Participates in Selenium-Enhanced Cold Tolerance of Cucumber Seedlings

et al. 2021

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“…Se deficiencies have also been associated with negative effects on embryo development [2,3,4]. Nowadays, researchers are working on new strategies for the normalization of this microelement level [2,3,5] and the possibilities of using Se in the creation of new drugs [6,7].…”

Section: Introductionmentioning

confidence: 99%

Serum Selenium Level in Early Healthy Pregnancy as a Risk Marker of Pregnancy Induced Hypertension

Lewandowska

Sajdak²,

Lubiński³

2019

Nutrients

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Selenium (Se) is an antioxidant nutrient whose deficiency can influence adverse outcomes of pregnancy. The aim of this study is to determine whether serum Se level in early healthy pregnancy may be a risk marker for pregnancy induced hypertension. We obtained data from our prospective study in which we recruited healthy women in weeks 10–14 of a single pregnancy. In this analysis, we examined 121 women who subsequently developed pregnancy-induced hypertension and matched 363 women who remained normotensive. We measured Se levels (using the ICP-MS technique) in the serum in weeks 10–14 of the pregnancy. The odds ratios of pregnancy-induced hypertension (95% confidence intervals) were calculated using multivariate logistic regression. We found that the mean Se level was lower in the case group compared to the control (57.51 vs. 62.89 μg/L; p = 2.6 × 10−10). Excessive body mass index (BMI) and smoking influenced the estimated odds ratios. In the subgroup of women who had never smoked with normal pre-pregnancy BMI, the adjusted odds ratio (AOR) of pregnancy-induced hypertension was 15.34 (95% CI: 2.73–86.31, p = 0.002) for Se levels in the lowest quartile (≤57.68 µg/L), as compared to the highest quartile (>66.60 µg/L), after adjusting for all the accepted confounders. In the whole cohort, the prognostic value of Se by logistic regression showed that the area under curve (AUC) = 0.814. In our study, one can consider the role of Se as a risk marker of pregnancy-induced hypertension.

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“…Indeed, prenyl chains have been selected from an evolutionary point of view as key determinants in the functions of a plethora of cell substructures, from bacteria to eukaryotes, that comprise mammals [ 27 ]. Secondly the coumarin nucleus is suggested by numerous literature data to be a versatile scaffold in drug design and discovery and a structural determinant for pharmacological activities [ 28 ]. Finally, the selenium atom, bridging the aforementioned moieties, may contribute to the overall effects thanks to the known activities (e.g., antioxidant) ascribed in the literature to selenoethers [ 29 ].…”

Section: Resultsmentioning

confidence: 99%

Semisynthesis of Selenoauraptene

et al. 2021

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Selenium-containing compounds are gaining more and more interest due to their valuable and promising pharmacological properties, mainly as anticancer and antioxidant agents. Ebselen, the up to now only approved drugs, is well known to possess very good glutathione peroxidase mimicking effects. To date, the most of efforts have been directed to build pure synthetic Se containing molecules, while less attention have been devoted to Se-based semisynthetic products resembling natural compounds like terpenes, polyphenols, and alkaloids. The aim of this short communication is to report the synthesis of the first example of a Se-phenylpropanoids, namely selenoauraptene, containing a selenogeranyl side chain in position 7 of the umbelliferone core. The key step was the Newman-Kwart rearrangement to obtain a selenocarbamate in which the Se atom was directly attached to umbelliferone (replacing its 7-OH function) followed by hydrolysis to get diumbelliferyl diselenide, which was finally easily converted to the desired Se-geranyl derivative in quite a good overall yield (28.5%). The synthesized adduct displayed a greater antioxidant and a radical scavenger in vitro activity than parent auraptene. The procedure we describe herein, to the best of our knowledge for the first time in the literature, represents an easy-to-handle method for the synthesis of a wide array of seleno analogues of naturally occurring biologically active oxyprenylated secondary metabolites.

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Celebrating Two Centuries of Research in Selenium Chemistry: State of the Art and New Prospective

Cited by 30 publications

References 18 publications

Melatonin Participates in Selenium-Enhanced Cold Tolerance of Cucumber Seedlings

Melatonin Participates in Selenium-Enhanced Cold Tolerance of Cucumber Seedlings

Serum Selenium Level in Early Healthy Pregnancy as a Risk Marker of Pregnancy Induced Hypertension

Semisynthesis of Selenoauraptene

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