Celastrol gel ameliorates imiquimod-induced psoriasis-like dermatitis in mice by targeting Langerhans cells

Liu, Liu; Chen, Xi; Lü, Yi; Sun, Xiaoying; Ze, Kan; Zhou, Yajun; Li, Wei; Li, Xin; Li, Hong-Jin; Li, Bin

doi:10.1016/j.biopha.2022.112644

Cited by 15 publications

(11 citation statements)

References 26 publications

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“…Similar effects may also be induced by Kaempferia parviflora extract [139]. Furthermore, traditional medicines may also ameliorate the inflammatory activity of LCs [140]. In addition, LCs are targeted by the topically applied vitamin D analog calcipotriol, which results in the suppression of imiquimod-induced psoriasis [141].…”

Section: Therapeutic Targeting Of Macrophage-dependent Cytokine and M...mentioning

confidence: 99%

Macrophage Functions in Psoriasis: Lessons from Mouse Models

Nazimek,

Bryniarski

2024

IJMS

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Psoriasis is a systemic autoimmune/autoinflammatory disease that can be well studied in established mouse models. Skin-resident macrophages are classified into epidermal Langerhans cells and dermal macrophages and are involved in innate immunity, orchestration of adaptive immunity, and maintenance of tissue homeostasis due to their ability to constantly shift their phenotype and adapt to the current microenvironment. Consequently, both macrophage populations play dual roles in psoriasis. In some circumstances, pro-inflammatory activated macrophages and Langerhans cells trigger psoriatic inflammation, while in other cases their anti-inflammatory stimulation results in amelioration of the disease. These features make macrophages interesting candidates for modern therapeutic strategies. Owing to the significant progress in knowledge, our review article summarizes current achievements and indicates future research directions to better understand the function of macrophages in psoriasis.

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Section: Therapeutic Targeting Of Macrophage-dependent Cytokine and M...mentioning

confidence: 99%

Macrophage Functions in Psoriasis: Lessons from Mouse Models

Nazimek,

Bryniarski

2024

IJMS

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“…It ameliorates psoriasis-like dermatitis and also has a glucocorticoid-like effect, which successfully prevents psoriasis recurrence. 70 Another study demonstrated that GTW (multi-glycoside of Tripterygium wilfordii Hook. f .)…”

Section: The Mechanism Of Actionmentioning

confidence: 99%

Tripterygium wilfordii Hook. F. and Its Extracts for Psoriasis: Efficacy and Mechanism

Wang,

Tian,

Huang

et al. 2023

DDDT

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Psoriasis is an inflammatory autoimmune skin condition that is clinically marked by chronic erythema and scaling. The traditional Chinese herb Tripterygium wilfordii Hook. F . (TwHF) is commonly used in the treatment of immune-related skin illnesses, such as psoriasis. In clinical studies, PASI (Psoriasis Area and Severity Index) were dramatically decreased by TwHF and its extracts. Their benefits for psoriasis also include relief from psoriasis symptoms such as itching, dryness, overall lesion scores and quality of life. And the pathological mechanisms include anti-inflammation, immunomodulation and potentially signaling pathway modulations, which are achieved by modulating type-3 inflammatory cytokines including IL-22, IL-23, and IL-17 as well as immune cells like Th17 lymphocytes, γδT cells, and interfering with IFN-SOCS1, NF-κB and IL- 36α signaling pathways. TwHF and its extracts may cause various adverse drug reactions, such as gastrointestinal responses, aberrant hepatocytes, reproductive issues, and liver function impairment, but at adequate doses, they are regarded as an alternative therapy for the treatment of psoriasis. In this review, the effectiveness and mechanisms of TwHF and its extracts in psoriasis treatment are elucidated.

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“…In a recent work, it was shown that diminished secretion of IL-23 by LCs reduced the interaction between LCs and γδ T cells, thereby inhibiting γδ T cells and, in turn, IL-17 secretion, ultimately leading to improvements in psoriasis-like symptoms in a murine model [30]. Interestingly, in cancer patients with immune-related adverse events (irAE), the development of psoriasis is associated with the loss of epidermal CD1a + LCs after treatment with immune checkpoint inhibitors (ICI).…”

Section: Role Of Langerhans Cells In Psoriasismentioning

confidence: 99%

“…Bacterial and viral infections Expression of pathogen-recognition receptors, secretion of cytokines, migration to skin draining lymph nodes to generate the adaptive immune response [2] Wounds Increased LC migration to skin draining lymph nodes mediated by enhanced expression of MICA B by keratinocytes [14,15]; TNF-mediated LC repopulation of the epidermis contributes to tissue remodeling [17,18] Other skin pathologies Psoriasis Pro-inflammatory role of LCs via increased secretion of IL-23, over-expression of CD1a and increased interaction with γδT cells [27,30] Contact dermatitis Uptake of allergens and immune response via antigen presentation to T cells [74] Atopic dermatitis Activated LCs migrate to skin draining lymph nodes to prime Th2 T cells, increased expression of the high-affinity immunoglobulin (Ig)E receptor [37][38][39][40]75] Skin cancers BCC LC are low in BCC [57] SCC Various levels of LC infiltration in SCC, alternatively low [56] or high densities [54].…”

Section: Pathology Lc Involvementmentioning

confidence: 99%

Langerhans Cells—Revising Their Role in Skin Pathologies

Neagu

Constantin

Jugulete

et al. 2022

JPM

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Langerhans cells (LCs) constitute a cellular immune network across the epidermis. Because they are located at the skin barrier, they are considered immune sentinels of the skin. These antigen-presenting cells are capable of migrating to skin draining lymph nodes to prime adaptive immune cells, namely T- and B-lymphocytes, which will ultimately lead to a broad range of immune responses. Moreover, LCs have been shown to possess important roles in the anti-cancer immune responses. Indeed, the literature nicely highlights the role of LCs in melanoma. In line with this, LCs have been found in melanoma tissues where they contribute to the local immune response. Moreover, the immunogenic properties of LCs render them attractive targets for designing vaccines to treat melanoma and autoimmune diseases. Overall, future studies will help to enlarge the portfolio of immune properties of LCs, and aid the prognosis and development of novel therapeutic approaches to treating skin pathologies, including cancers.

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Celastrol gel ameliorates imiquimod-induced psoriasis-like dermatitis in mice by targeting Langerhans cells

Cited by 15 publications

References 26 publications

Macrophage Functions in Psoriasis: Lessons from Mouse Models

Macrophage Functions in Psoriasis: Lessons from Mouse Models

Tripterygium wilfordii Hook. F. and Its Extracts for Psoriasis: Efficacy and Mechanism

Langerhans Cells—Revising Their Role in Skin Pathologies

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