Celastrol attenuates Guillain-Barré syndrome by inhibiting TLR4/NF-κB/STAT3 pathway-mediated Th1/Th17 cell differentiation

Shao, Hefang; Fan, Weijiao; Yang, Tao

doi:10.4149/gpb_2022048

gpb

2023

DOI: 10.4149/gpb_2022048

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Celastrol attenuates Guillain-Barré syndrome by inhibiting TLR4/NF-κB/STAT3 pathway-mediated Th1/Th17 cell differentiation

Hefang Shao¹,

Weijiao Fan²,

Tao Yang³

Abstract: Highlights1. Celastrol dose-dependently restrained the pathological damage of GBS in EAN rats. 2. Celastrol suppressed Th1/Th17 cell differentiation in EAN rats. 3. Celastrol inhibited the TLR4/ NF-κB/STAT3 signaling pathway in EAN rats.

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Research Progress on Improving Autoimmune Diseases with Celastrol

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Celastrol attenuates Guillain-Barré syndrome by inhibiting TLR4/NF-κB/STAT3 pathway-mediated Th1/Th17 cell differentiation

Abstract: Highlights1. Celastrol dose-dependently restrained the pathological damage of GBS in EAN rats. 2. Celastrol suppressed Th1/Th17 cell differentiation in EAN rats. 3. Celastrol inhibited the TLR4/ NF-κB/STAT3 signaling pathway in EAN rats.

Cited by 1 publication

References 56 publications

Research Progress on Improving Autoimmune Diseases with Celastrol

Research Progress on Improving Autoimmune Diseases with Celastrol

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