Cefuroxime axetil loaded solid lipid nanoparticles for enhanced activity against S. aureus biofilm

Singh, Bhupender L.; Vuddanda, Parameswara Rao; Vijayakumar, Mahalingam Rajamanickam; Kumar, Vinod; Saxena, Preeti S.; Singh, Sanjay

doi:10.1016/j.colsurfb.2014.03.046

Cited by 62 publications

(43 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[59] Finally, SLNs obtained with the optimized process presented a spherical shape. This result is in accordance with the literature, Singh et al [64] and Dudhipala and Veerabrahma, [65] also obtained spherical SLNs using a similar process with respectively tristearin and triglycerides (Dynasan 116) as lipid materials. [64,65] Petrolatum SLNs were prepared with the optimized protocol; 5% petrolatum, 0.3% polysorbate 40, 0.2% sorbitan palmitate and 94.5% deionized water were warmed up to 70°C.…”

Section: Petrolatum Sln Development: Optimization Processsupporting

confidence: 93%

“…This result is in accordance with the literature, Singh et al [64] and Dudhipala and Veerabrahma, [65] also obtained spherical SLNs using a similar process with respectively tristearin and triglycerides (Dynasan 116) as lipid materials. [64,65] Petrolatum SLNs were prepared with the optimized protocol; 5% petrolatum, 0.3% polysorbate 40, 0.2% sorbitan palmitate and 94.5% deionized water were warmed up to 70°C. The emulsion was stirred for 300 s under 24,000 rpm at 70°C and then homogenized with sonication during 60 s under 200 W. SLNs presented a mean size of 195 nm and a PDI 0.149 with a spherical shape ( Figure 5).…”

Section: Petrolatum Sln Development: Optimization Processsupporting

confidence: 93%

“…The encapsulation of cefuroxime aexil in stearic acid SLNs was closed to 20%, whereas in stearic acid tristearin mix (50:50) SLNs, EE% was 65%. [64] In our study, all the lipids were composed of several ingredients and this could explain the high EE% observed. Lowest EE% was obtained with petrolatum SLNs 66.4% (±0.5), then ranged by increasing values: C10-18 triglycerides 84.4% (±1.1), shea butter 88.4% (±1.0), candelilla 88.9% (±0.8), cetyl palmitate 94.9% (±0.5).…”

Section: Fragrance Encapsulation In Slnsmentioning

confidence: 79%

See 2 more Smart Citations

Hot homogenization process optimization for fragrance encapsulation in solid lipid nanoparticles

Cortial

Vocanson

Loubry

et al. 2015

Flavour & Fragrance J

View full text Add to dashboard Cite

Solid lipid nanoparticles (SLNs) loaded with perfume were prepared using a hot homogenization process coupled with ultrasounds. The objective was to develop a simple process adjustable to several kinds of lipids. The process comprised two steps: a pre-emulsion of the melted lipids in water followed by a size reduction by sonication, before cooling. The study of several formulation parameters showed that the size distribution of SLNs depended essentially on the sonication step, and especially on the ultrasounds power and time. Five types of SLNs loaded with perfume were produced, based on petrolatum, candelilla, shea butter, C10-18 triglycerides, and cetyl palmitate. The size distribution was below 200 nm with a narrow size distribution. Moreover, high encapsulation efficiency was obtained, at least 66.5% (±0.5) for petrolatum SLNs and 94.9% (±0.5) for cetyl palmitate SLNs and the loading % was comprised between 4.9% (±0.5) (petrolatum) and 7.0% (±0.5) (cetyl palmitate). A correlation between the partition coefficient of the molecules and the encapsulation efficiency was established for all lipids except cetyl palmitate. Cetyl palmitate, candelilla and petrolatum SLNs were stable for at least one month at 4°C and 25°C.

show abstract

Section: Petrolatum Sln Development: Optimization Processsupporting

confidence: 93%

Section: Petrolatum Sln Development: Optimization Processsupporting

confidence: 93%

Section: Fragrance Encapsulation In Slnsmentioning

confidence: 79%

See 1 more Smart Citation

Hot homogenization process optimization for fragrance encapsulation in solid lipid nanoparticles

Cortial

Vocanson

Loubry

et al. 2015

Flavour & Fragrance J

View full text Add to dashboard Cite

show abstract

“…Pure irbesartan showed a sharp peak (endotherm) at 181°C corresponding to its melting point/transition temperature. There was a shift in the melting point of the drug when it was formulated into SLN indicating reduced crystallinity of drug (Singh et al, 2014).…”

Section: Differential Scanning Calorimetry and Ft-ir Spectroscopymentioning

confidence: 99%

Solid lipid nanoparticles of irbesartan: preparation, characterization, optimization and pharmacokinetic studies

Soma

Attari

Reddy

et al. 2017

Braz. J. Pharm. Sci.

View full text Add to dashboard Cite

Irbesartan is an antihypertensive with limited bioavailability and solid lipid nanoparticles (SLN) is one of the approaches to improve bioavailability. Solid lipid nanoparticles were prepared using glyceryl monostearate by solvent emulsification method followed by probe sonication. Irbesartan loaded SLNs were characterized and optimized by parameters like particle size, zeta potential, surface morphology entrapment efficiency and in vitro release. The optimized formulation was then further evaluated for the pharmacokinetic studies in Wistar rats. Irbesartan-loaded SLN of particle size 523.7 nm and 73.8% entrapment efficiency showed good bioavailability in Wistar rats and also showed optimum stability in the studies. The SLN prepared using glyceryl monostearate by solvent emulsification method leads to improve bioavailability of the drug.

show abstract

“…209 Singh et al, 210 with an aim to increase antimicrobial activity against S. aureus biofilms, developed SLNs containing cefuroxime axetil (CA). The authors used stearic acid (SA) as a single lipid and SA and tristearin (TRI) as a binary lipid; the emulsification-evaporation method was used for the formation of SLNs.…”

mentioning

confidence: 99%

Nanotechnology-based drug delivery systems for control of microbial biofilms: a review

Ramos¹,

Silva²,

Spósito³

et al. 2018

IJN

210

View full text Add to dashboard Cite

Since the dawn of civilization, it has been understood that pathogenic microorganisms cause infectious conditions in humans, which at times, may prove fatal. Among the different virulent properties of microorganisms is their ability to form biofilms, which has been directly related to the development of chronic infections with increased disease severity. A problem in the elimination of such complex structures (biofilms) is resistance to the drugs that are currently used in clinical practice, and therefore, it becomes imperative to search for new compounds that have anti-biofilm activity. In this context, nanotechnology provides secure platforms for targeted delivery of drugs to treat numerous microbial infections that are caused by biofilms. Among the many applications of such nanotechnology-based drug delivery systems is their ability to enhance the bioactive potential of therapeutic agents. The present study reports the use of important nanoparticles, such as liposomes, microemulsions, cyclodextrins, solid lipid nanoparticles, polymeric nanoparticles, and metallic nanoparticles, in controlling microbial biofilms by targeted drug delivery. Such utilization of these nanosystems has led to a better understanding of their applications and their role in combating biofilms.

show abstract

Cefuroxime axetil loaded solid lipid nanoparticles for enhanced activity against S. aureus biofilm

Cited by 62 publications

References 15 publications

Hot homogenization process optimization for fragrance encapsulation in solid lipid nanoparticles

Hot homogenization process optimization for fragrance encapsulation in solid lipid nanoparticles

Solid lipid nanoparticles of irbesartan: preparation, characterization, optimization and pharmacokinetic studies

Nanotechnology-based drug delivery systems for control of microbial biofilms: a review

Contact Info

Product

Resources

About