Ceftriaxone Therapy in Pediatric Patients

Harrison, Christopher J.

doi:10.1001/archpedi.1983.02140370010004

Cited by 13 publications

(9 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Except for the patient with hives and the one with an SGPT level of 150 U/ml, none of these side effects necessitated discontinuation of the drug. DISCUSSION Several groups of investigators have previously reported on the usefulness and efficacy of ceftriaxone in the treatment of a variety of bacterial infections in children and adults (1,2,4,6,9,14). In these studies, ceftriaxone was not useful in the treatment of infections due to Pseudomonas aeruginosa or enterococcus or in patients with ventriculoperitoneal shunt infections.…”

Section: Resultsmentioning

confidence: 97%

“…Another area of greater importance to the practitioner is the usefulness of ceftriaxone in the treatment of serious staphylococcal infections. Harrison et al (9) had a treatment failure with ceftriaxone in a patient with a periorbital cellulitis due to a relatively resistant S. aureus strain. Although the organism appeared to be sensitive by the disk method, the MIC of ceftriaxone for this organism was 32 ,ug/ml.…”

Section: Resultsmentioning

confidence: 99%

“…In addition, it has modest central nervous system penetration, making it useful in the treatment of bacterial meningitis (7,13). Several investigators have previously demonstrated its efficacy when used at a dose of 75 mg/kg per day in two divided doses (1,4,6,8,9,14). In this study, we evaluated the clinical efficacy and pharmacokinetics of ceftriaxone when administered as a single daily dose for children with serious bacterial infections.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Once-daily ceftriaxone therapy for serious bacterial infections in children

Congeni

Chonmaitree

Rakusan

et al. 1985

Antimicrob Agents Chemother

View full text Add to dashboard Cite

Ceftriaxone administered as a single daily dose of 50 mg/kg was evaluated in the treatment of 35 children with a variety of nonmeningitic bacterial infections. In two of the patients, the drug was discontinued before the response to the drug could be evaluated. All of the remaining patients had a satisfactory response. In 22 of the patients, plasma was available for the determination of ceftriaxone levels 1 h after a dose and immediately before the next dose. All but one of these patients had trough ceftriaxone levels which exceeded the MIC of the infecting organism, although marginally so for Staphylococcus aureus. Ceftriaxone appears to be safe and effective in the treatment of a variety of bacterial pathogens in children when administered at a single daily dose of 50 mg/kg. This drug may be especially useful in those patients in whom outpatient antibiotic therapy is contemplated or in whom maintenance of intravenous access is difficult.

show abstract

Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Once-daily ceftriaxone therapy for serious bacterial infections in children

Congeni

Chonmaitree

Rakusan

et al. 1985

Antimicrob Agents Chemother

View full text Add to dashboard Cite

show abstract

“…Therapeutic failures may be due to high minimal inhibitory concentrations (MICs) [46,47]. The MIC for ceftriaxone was < 0.25 for all our isolates, yet our patient with purulent meningitis required 24 days of parenteral therapy.…”

Section: Discussionmentioning

confidence: 83%

Salmonella Meningitis: Report of Three Cases in Adults and Literature Review

Karim

Islam

2002

Infection

View full text Add to dashboard Cite

Salmonella meningitis is an unusual complication of Salmonella sepsis and occurs almost exclusively in infants and young children. One case of Salmonella meningitis and two cases of cerebrospinal fluid (CSF) pleocytosis in adult patients with Salmonella bacteremia were studied and the literature was reviewed. On a retrospective review of the charts of 100 sequential patients with Salmonella typhi and S. paratyphi-positive blood cultures, we found one patient with fulminant Salmonella meningitis and two others with CSF pleocytosis. All three patients survived. The patient with Salmonella meningitis had significant residual neurologic sequela. Salmonella encephalopathy occurred in six other patients who presented with headache and were confused or drowsy. Cases of meningitis in adults do occur and are associated with a high morbidity and mortality. Newer cephalosporn antibiotics may be the therapy of choice in these infections.

show abstract

“…In contrast, only 5% of cefotaxime and ceftizoxime are excreted into bile. As a result, a higher incidence of diarrhoea (10 to 40%) [Eron et al 1983;Harrison et al 1983;Nahata & Miller 1989;Smith et al 1989) has been reported with ceftriaxone than with cefotaxime (1.2%) [Smith 1981), presumably because of increased intraintestinal concentrations and altered faecal flora.…”

Section: Gastrointestinal Reactionsmentioning

confidence: 99%

Adverse Effects of Newer Cephalosporins

Thompson

Jacobs

1993

Drug Safety

View full text Add to dashboard Cite

While classifications into generations according to antimicrobial activity has helped clinicians incorporate the increasing number of cephalosporins into their pharmacological repertoire, adverse effects among the different agents fail to follow similar categories. In general, cephalosporins are fairly well tolerated antibiotics, and toxicity has been limited to specific agents. Subtle differences in chemical structure and pharmacokinetics can influence the potential for adverse effects. The route of administration may result in minor adverse reactions, including thrombophlebitis and pain. The most common adverse effects of cephalosporins are allergic reactions, occurring in 0.9 to 3.2% of patients. Cephalosporins have very rarely been associated with haematological toxicity (less than 1% of patients), but specific agents have been associated with neutropenia, hypoprothrombinaemia, haemolytic anaemia, and problems with platelet production and function. Other reactions include localised gastrointestinal disturbances, hepatotoxicity (e.g. biliary sludging), nephrotoxicity and mild central nervous system effects. The cephalosporins are generally well tolerated in the paediatric population. Very few interactions have been observed between cephalosporins and other drugs, largely because cephalosporins do not affect the microsomal P450 hepatic enzyme system. While cephalosporins are considered to be relatively 'safe' drugs, the introduction of newer members warrants continued careful observation for reporting of adverse drug reactions.

show abstract

Ceftriaxone Therapy in Pediatric Patients

Cited by 13 publications

References 9 publications

Once-daily ceftriaxone therapy for serious bacterial infections in children

Once-daily ceftriaxone therapy for serious bacterial infections in children

Salmonella Meningitis: Report of Three Cases in Adults and Literature Review

Adverse Effects of Newer Cephalosporins

Contact Info

Product

Resources

About