Ceftriaxone-induced hemolysis

Guleria, Vivek Singh; Sharma, Nitin; Sagar, Amitabh; Nair, Velu

doi:10.4103/0253-7613.117758

Cited by 12 publications

(7 citation statements)

References 5 publications

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“…Reports suggested that the haemolytic effects of antimicrobial peptides tyrocidine A and gramicidin S, limited their use as topical agents [67,68]. Ceftriaxone, a third-generation cephalosporin was also reported to cause haemolysis, attracting advise for restricted administration of the drug [69]. So, it is very important for a potential drug to be tested for its haemolytic activity to secure critical information on its clinical suitability.…”

Section: Haemolytic Activitymentioning

confidence: 99%

Isolation and Characterization of a New Endophytic Actinobacterium Streptomyces californicus Strain ADR1 as a Promising Source of Anti-Bacterial, Anti-Biofilm and Antioxidant Metabolites

Singh

Dubey

2020

Microorganisms

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In view of the fast depleting armamentarium of drugs against significant pathogens, like methicillin-resistant Staphylococcus aureus (MRSA) and others due to rapidly emerging drug-resistance, the discovery and development of new drugs need urgent action. In this endeavor, a new strain of endophytic actinobacterium was isolated from the plant Datura metel, which produced secondary metabolites with potent anti-infective activities. The isolate was identified as Streptomyces californicus strain ADR1 based on 16S rRNA gene sequence analysis. Metabolites produced by the isolate had been investigated for their antibacterial attributes against important pathogens: S. aureus, MRSA, S. epidermis, Enterococcus faecium and E. faecalis. Minimum inhibitory concentration (MIC90) values against these pathogens varied from 0.23 ± 0.01 to 5.68 ± 0.20 μg/mL. The metabolites inhibited biofilm formation by the strains of S. aureus and MRSA (Biofilm inhibitory concentration [BIC90] values: 0.74 ± 0.08–4.92 ± 0.49 μg/mL). The BIC90 values increased in the case of pre-formed biofilms. Additionally, the metabolites possessed good antioxidant properties, with an inhibitory concentration (IC90) value of 217.24 ± 6.77 µg/mL for 1, 1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging. An insight into different classes of compounds produced by the strain ADR1 was obtained by chemical profiling and GC-MS analysis, wherein several therapeutic classes, for example, alkaloids, phenolics, terpenes, terpenoids and glycosides, were discovered.

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Section: Haemolytic Activitymentioning

confidence: 99%

Isolation and Characterization of a New Endophytic Actinobacterium Streptomyces californicus Strain ADR1 as a Promising Source of Anti-Bacterial, Anti-Biofilm and Antioxidant Metabolites

Singh

Dubey

2020

Microorganisms

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“…Artesunate-related hemolysis is a potential cause of AIHA (DIHA) in patients with malaria, and is related to delayed immune-mediated hemolysis [3]. To our knowledge, only 1 study has demonstrated that ceftriaxone is related to DIHA, but not related to the production of autoantibodies [16]. Two medications (artesunate and ceftriaxone) might have induced DIHA in our present patient.…”

Section: Discussionmentioning

confidence: 54%

Autoimmune hemolytic anemia and autoantibodies in a patient with Plasmodium falciparum infection: report of a rare case and review of the literature

et al. 2017

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Background Anemia is a common problem among patients with malaria infection, which induces hemolysis during treatment. A few patients present with autoimmune hemolytic anemia (AIHA) and autoantibodies, such as autoanti-E and autoanti-I, during malaria infection. Objective To report the clinical response of a patient with Plasmodium falciparum malaria infection with a hemolytic condition. Methods We reviewed medical records of a patient with P. falciparum malaria and related literature. Results Our patient presented with P. falciparum malaria infection and received artesunate and ceftriaxone to cover potential tropical infectious diseases. After malaria parasite was eradicated, her hemoglobin declined, and AIHA and autoantibodies were found, explaining the cause of anemia. Corticosteroid was given at a standard dosage, and her hemoglobin became normal within 1 week. Conclusion Patients with falciparum malaria and both AIHA and autoantibody complications are rare. Our patient responded to malaria eradication and corticosteroid treatment. Most cases reported seem to respond to corticosteroid with a variety of recovery times. However, corticosteroids might increase the severity of infection; more clinical data to support a standard regimen to treat properly rare hematologic complications (AIHA and autoantibodies) in malaria patients are warranted.

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“…Ceftriaxone, along with other cephalosporin antibiotics, are most commonly associated with DDAB formation [2,9]. Extravascular hemolysis may result from the production of non-complement-activating, drug-dependent antibodies (DDAB) [10].…”

Section: Discussionmentioning

confidence: 99%

“…For clinical management of a DIIHA, it is useful to categorize the involved antibody as drug-dependent (DDAB) or drug-independent (DIAB) [ 2 ]. Ceftriaxone, along with other cephalosporin antibiotics, are most commonly associated with DDAB formation [ 2 , 9 ]. Extravascular hemolysis may result from the production of non-complement-activating, drug-dependent antibodies (DDAB) [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Ceftriaxone-Induced Hemolytic Anemia in a Jehovah’s Witness

Tasch

Gonzalez-Zayaz

2017

Am J Case Rep

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Patient: Female, 65Final Diagnosis: Ceftriaxone induced immune hemolytic anemiaSymptoms: Blindness • fatigueMedication: —Clinical Procedure: —Specialty: HematologyObjective:Unusual clinical courseBackground:Drug-induced immune hemolytic anemia (DIIHA) is a rare condition that may result from the administration of an antibiotic, most notably the cephalosporin class, commonly used in both the adult and pediatric populations. A delay in recognition by a provider may lead to continuation of the offending agent and possibly result in fatal outcomes.Case Report:We report the case of a 65-year-old woman on ceftriaxone infusions after being diagnosed with acute mitral valve endocarditis 3 weeks prior, which presented with severe anemia and bilateral transient vision loss. Being a Jehovah’s Witness, the patient refused blood product transfusions and was managed with alternative therapies. The etiology of the symptoms was suspected to be a hemolytic anemia directly related to her ceftriaxone infusions.Conclusions:This report demonstrates the importance of close vigilance while prescribing drugs known to cause hemolytic anemia. Although rare, drug-induced immune hemolytic anemia caused by ceftriaxone may be a potentially fatal condition, but with early recognition and withdrawal of the offending agent, successful treatment may ensue. Serological tests should be utilized to obtain a definitive diagnosis.

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Ceftriaxone-induced hemolysis

Cited by 12 publications

References 5 publications

Isolation and Characterization of a New Endophytic Actinobacterium Streptomyces californicus Strain ADR1 as a Promising Source of Anti-Bacterial, Anti-Biofilm and Antioxidant Metabolites

Isolation and Characterization of a New Endophytic Actinobacterium Streptomyces californicus Strain ADR1 as a Promising Source of Anti-Bacterial, Anti-Biofilm and Antioxidant Metabolites

Autoimmune hemolytic anemia and autoantibodies in a patient with Plasmodium falciparum infection: report of a rare case and review of the literature

Ceftriaxone-Induced Hemolytic Anemia in a Jehovah’s Witness

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