Ceftriaxone induced drug rash with eosinophilia and systemic symptoms

Guleria, Vivek Singh; Dhillon, Mukesh; Gill, SS; Naithani, Nardeep

doi:10.4103/2279-042x.137077

Cited by 14 publications

(8 citation statements)

References 8 publications

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“…In this study, there was significant (p < 0.05) reduction in the mean total white blood cell, neutrophil and lymphocyte count of dogs in group C from day 14 until the experiments ended on day 28. This observation corroborates the neutropaenia observed in a patient suffering from pneumonia who received CFZ for 11 days [14].…”

Section: Discussionsupporting

confidence: 89%

Clinico-toxicological effects of ceftriaxone after intramuscular administration of graded doses in Basenji dogs

Eze¹,

Eke²,

Anaga³

et al. 2021

Trop. J. Pharm Res

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Purpose: The recent ceftriaxone-induced anaemia and mortalities at the dose of 50 mg/kg in Veterinary Teaching Hospital, University of Nigeria prompted this study which sought to assess the clinicotoxicological effects of ceftriaxone (CFZ) after intramuscular administration of graded doses in Basenji dogs.Methods: The effects of CFZ on the haematological indices, physiological parameters, liver and kidney functions were assessed in 4 group of dogs (n = 4) designated A – D. They were given CFZ intramuscularly for 21 days at doses of 12, 25 and 50 mg/kg for groups A, B, C, respectively, while thecontrol (group D) received the diluent (lignocaine 0.2 mL)Results: The mean pulse and heart rate of dogs in group C were significantly (p < 0.05) higher than those of group A, B and D. Significant (p < 0.05) decrease in red blood cell count (RBC), haemoglobin concentration (Hb) and packed cell volume (PCV) was observed in group C on days 7 and 14, while on day 21, these parameters were significantly (p < 0.05) higher in group D than in the treated groups. On day 14 of CFZ administration, the alanine transaminase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) activities of dogs in group C was significantly (p < 0.05) elevated than the control group.Conclusion: These findings suggest that CFZ, at the doses of 12.5 - 25 mg/kg, appears safe in dogs as most of the adverse effects observed are reversed following the withdrawal of the drug on day 28. However, CFZ at 50 mg/kg causes anaemia, tachycardia and bilateral paralysis of the hind limbs which did not revert to normal after one week; hence, it is not recommended for use in dogs at this dose.

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Section: Discussionsupporting

confidence: 89%

Clinico-toxicological effects of ceftriaxone after intramuscular administration of graded doses in Basenji dogs

Eze¹,

Eke²,

Anaga³

et al. 2021

Trop. J. Pharm Res

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“…In the case described above, the possible culprits for triggering the DRESS syndrome were omeprazole, ceftriaxone or acyclovir. The specific hypersensitivity drug reaction seen in DRESS is rarely triggered by these medications as demonstrated by the few case reports [9,10]. We are unable to find a case report describing Acyclovir-induced DRESS syndrome, however there are documented cases of acyclovir triggering other hypersensitivity reactions [11,12].…”

Section: Discussioncontrasting

confidence: 41%

Successful treatment of DRESS syndrome with plasmapheresis during the course of sero-negative autoimmune encephalitis: a case report

Taylor¹,

Yeap²,

Sharples³

et al. 2017

EJMCR

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“…These cells release interleukin-5 which activates eosinophils and sets up an inflammatory cascade. 5…”

Section: Discussionmentioning

confidence: 99%

Drug Rash With Eosinophilia and Systemic Symptoms (DRESS) Syndrome Probably Related to Cefpodoxime: A Case Report

Babu

Panachiyil

Sebastian

et al. 2019

Journal of Pharmacy Practice

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Cefpodoxime is a common antibiotic with a favorable side effect profile. Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) syndrome has been described with several cephalosporins but not cefpodoxime. We report the probable first case of cefpodoxime-induced DRESS syndrome in a 52-year-old female patient. In our case, the patient presented with symptoms of DRESS syndrome 16 days after initiation of cefpodoxime. This case highlights the necessity of consideration of an iatrogenic reason for presenting signs and symptoms at all times. Reinforcing the importance of taking a thorough drug history and considering drug reactions even if onset of symptoms are delayed.

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Ceftriaxone induced drug rash with eosinophilia and systemic symptoms

Cited by 14 publications

References 8 publications

Clinico-toxicological effects of ceftriaxone after intramuscular administration of graded doses in Basenji dogs

Clinico-toxicological effects of ceftriaxone after intramuscular administration of graded doses in Basenji dogs

Successful treatment of DRESS syndrome with plasmapheresis during the course of sero-negative autoimmune encephalitis: a case report

Drug Rash With Eosinophilia and Systemic Symptoms (DRESS) Syndrome Probably Related to Cefpodoxime: A Case Report

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