Ceftiofur use and antimicrobial stewardship in the horse

Ryan, Clare A.; McNeal, Christina D.; Credille, Brent

doi:10.1111/evj.13930

Cited by 5 publications

(4 citation statements)

References 96 publications

(215 reference statements)

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“…(Hardefeldt et al., 2019; Younkin et al., 2019). Cephalosporins have a broader spectrum of action, with greater activity against Enterobacteriaceae compared to penicillins, increasing their potential activity according to their generation (Ryan et al., 2023).…”

Section: Discussionmentioning

confidence: 99%

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Antimicrobial use as an adjunctive treatment in dental‐related sinusitis in horses: A systematic review

Souza,

Mendes,

de Souza

et al. 2023

Equine Veterinary Education

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SummaryDental‐related sinusitis is a common condition in horses and often involves polymicrobial infection. Tooth extraction followed by sinus lavage and debridement are the recommended treatment. However, infection may persist or recur due to incomplete removal of infected material or, in rare cases, potential antimicrobial resistance. Although the use of antibiotics may be considered, evidence supporting their indication is scarce. This systematic literature review sets out to examine existing evidence supporting the use of antimicrobial therapy in dental‐related sinusitis in horses. Five articles (retrospective studies, prospective studies and case series) were included. Doxycycline, sulphadiazine‐trimethoprim, metronidazole and procaine benzylpenicillin combined with neomycin were the most commonly used antimicrobials. Oxytetracycline, gentamicin and cephazolin were used to a lesser extent. Two or more active pharmaceutical substances were often combined. In all studies, antimicrobial therapy was used as an ancillary strategy and criteria for drug selection were not reported. This review highlighted the scarcity of evidence supporting the use of antimicrobials in horses with dental‐related sinusitis. In cases with positive clinical outcomes, it was not possible to determine whether clinical improvement was due to antibiotics or other therapeutic interventions. Therefore, the actual contribution of antimicrobials could not be established.

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Section: Discussionmentioning

confidence: 99%

“…The beta‐lactams generally penetrate body fluids well, but do not cross biological membranes well, as they are not very fat‐soluble, except in acute inflammation (Kuroda et al., 2023; Prescott et al., 2013; Ryan et al., 2023). There are no studies demonstrating its bioavailability in the sinus cavity of horses.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial use as an adjunctive treatment in dental‐related sinusitis in horses: A systematic review

Souza,

Mendes,

de Souza

et al. 2023

Equine Veterinary Education

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“…Furthermore, antimicrobial drug resistance is not only a concern in the human medical field, but reports in equine veterinary medicine exist describing multidrug resistant infections with Staphylococcus, Escherichia coli, and Enterococci, as well as methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococci, and rifampin-and macrolide-resistant Rhodococcus equi [28][29][30][31][32][33][34][35][36][37][38]. The impact of antimicrobial resistance on equine practice specifically, challenges to appropriate use, and the opportunity to improve clinical outcomes through responsible antimicrobial use, including in critical patients, has been emphasized in several pertinent recent review articles [25,[39][40][41][42][43][44][45]. Factors contributing to appropriate antimicrobial use, such as indication for administration, selection, dosing, timing, route, duration, modification, and therapy have been reviewed recently by Hardefeldt et al [46].…”

Section: Discussionmentioning

confidence: 99%

The Effects of Antimicrobial Protocols and Other Perioperative Factors on Postoperative Complications in Horses Undergoing Celiotomy: A Retrospective Analysis, 2008–2021

Rockow,

Griffenhagen,

Landolt

et al. 2023

Animals

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Recognition of antimicrobial resistance in equine practice has increased over the past decade. The objective of this study was to provide an updated retrospective review of antimicrobial regimens in one tertiary referral hospital and to evaluate the association with postoperative complications. A secondary objective was to evaluate other perioperative factors including surgical procedure, anesthetic and recovery parameters, and the effect of perioperative medications on complications and outcomes. A computerized search of medical records was performed to identify horses undergoing exploratory celiotomy from 1 January 2008 to 31 December 2021. A total of 742 celiotomies were performed (608 completed, 134 terminated intraoperatively). Factors recorded were evaluated using logistic regression for the presence of either incisional infection, postoperative ileus, or other complications postoperatively. Antimicrobial type or timing (pre-, intra-, or postoperative) were not associated with decreased risk of incisional infection or postoperative ileus; however, the duration of NSAID use was positively associated with incisional infection (OR 1.14 per day). Lidocaine and alpha-2-agonist administration postoperatively were also associated with increased incidence of postoperative ileus (OR 21.5 and 1.56, respectively). Poor recovery quality (OR 4.69), the addition of other antimicrobials besides penicillin/gentamicin postoperatively (OR 3.63), and an increased number of different NSAID classes used (OR 1.46 per additional) were associated with other complications. Implementation of enterotomy was associated with decreased risk of other complications (OR 0.64). These findings provide an updated summary of factors associated with postoperative complications in horses undergoing celiotomy.

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“…Enrofloxacin belongs to the quinolone group and is used as a broad-spectrum antimicrobial substance due to its bactericidal effects [ 13 , 14 ]. Ceftiofur is a third-generation cephalosporine with a long-lasting efficacy and is traditionally used as an injectable [ 15 , 16 ]. Colistin is a polymyxin antimicrobial substance changing the structure of the outer cell membrane of Gram-negative bacteria, leading to leakage and consequently to cell-death [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Susceptibility from a One Health Perspective Regarding Porcine Escherichia coli from Bavaria, Germany

Ade,

Riehm,

Stadler

et al. 2023

Antibiotics

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Antimicrobial resistance is one of the most crucial One Health topics worldwide. Consequently, various national and international surveillance programs collect data and report trends regularly. Ceftiofur, colistin and enrofloxacin belong to the most important and critical class of anti-infective medications in both human and veterinary medicine. In the present study, antimicrobial resistance was analyzed using the epidemiological cut-off (ECOFF) value on 6569 Escherichia coli isolated from pigs in Bavaria, Germany, during five years, from 2016 to 2020. The statistically relevant results regarding antimicrobial resistance revealed a decrease for colistin, an increase for enrofloxacin, and a constant level for ceftiofur. In Germany, the usage of all three antimicrobial substances in livestock has fallen by 43.6% for polypeptides, 59.0% for fluoroquinolones and 57.8% for the 3rd + 4th generation cephalosporines during this time. Despite the decline in antimicrobial usage, a reduction regarding antimicrobial resistance was solely observed for colistin. This finding illustrates that in addition to the restriction of pharmaceutical consumption, further measures should be considered. Improved biosecurity concepts, a reduction in crowding, and controlled animal movements on farms may play a key role in finally containing the resistance mechanisms of bacteria in farm animals.

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Ceftiofur use and antimicrobial stewardship in the horse

Cited by 5 publications

References 96 publications

Antimicrobial use as an adjunctive treatment in dental‐related sinusitis in horses: A systematic review

Antimicrobial use as an adjunctive treatment in dental‐related sinusitis in horses: A systematic review

The Effects of Antimicrobial Protocols and Other Perioperative Factors on Postoperative Complications in Horses Undergoing Celiotomy: A Retrospective Analysis, 2008–2021

Antimicrobial Susceptibility from a One Health Perspective Regarding Porcine Escherichia coli from Bavaria, Germany

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