Ceftaroline Activity against
            <i>mecC</i>
            -Containing Staphylococcus aureus

Lahiri, S. C.; Alm, Richard A.

doi:10.1128/jcm.01411-15

Cited by 2 publications

(1 citation statement)

References 11 publications

(15 reference statements)

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“…We applied WGS in order to investigate the genomic context of the mecC gene, and the phylogenetic lineage of the strain. WGS of strain SA10610 revealed 100% identity to the mecC gene sequence of S. aureus strain TRN6234, isolated from a patient in a German hospital with a wound infection, 30 and 99.9% identity to the mecC gene sequence of strain M10/0061 isolated from an 85-year-old male inpatient in a regional hospital in south Ireland in 2010. 7 The SCC mec sequence of strain SA10610 showed 99.9% identity to SCC mec type XI of strain M10/0061.…”

Section: Resultsmentioning

confidence: 99%

mecC MRSA in Israel—genomic analysis, prevalence and global perspective

Baum

Anuka

Treygerman

et al. 2022

JAC-Antimicrobial Resistance

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Background MRSA is a major global healthcare problem. In 2011, a new mec variant designated mecC was described, presenting partial identity at the DNA level, thus undetectable by routine mecA PCR. Objectives Until now, no reliable information regarding mecC MRSA prevalence was available in Israel. In this study, to the best of our knowledge, we describe the first case of mecC MRSA in Israel, with focus on genomic analysis and global context. Methods The mecC MRSA isolate was analysed by WGS with focus on phylogeny, global contextualization, virulence and resistance genes. The strain was characterized by antibiotic susceptibility testing, spa typing and presence of mecA/C and pvl genes. Results An MRSA strain (SA10610), isolated from a urine sample of an 83-year old patient, was found negative for the mecA and pvl genes. The MLST and spa type were ST130 and t1736, respectively. SA10610 presented resistance to oxacillin, penicillin and cefoxitin, and susceptibility to all non-β-lactam agents tested. Phylogenetic comparison with a global dataset of 586 mecC MRSA genomes revealed substantial genomic divergence. The nearest genomic relatives were human and animal isolates from Denmark. A screen of 12 761 S. aureus isolates collected during 2011–18 in Israel indicated this is the only mecC-positive strain. Conclusions A high degree of genetic variability was found between the SA10610 strain and previously sequenced mecC MRSA isolated worldwide. The genomic and phylogenetic analysis suggest that mecC MRSA isolates have evolved independently rather than from a common ancestor.

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Section: Resultsmentioning

confidence: 99%