Cefotaxime‐induced drug reaction with eosinophilia and systemic symptom in a child with cross‐reactivity to other cephalosporins and cosensitization to teicoplanin

Abstract

Drug reaction with eosinophilia and systemic symptom (DRESS) is a severe adverse drug‐induced reaction. Commonly related to anticonvulsant and allopurinol, DRESS can affect both adults and children. Cefotaxime is rarely associated with DRESS, especially with children. We report a cefotaxime‐induced DRESS in a child and emphasize the role of allergological work‐up to point out the culprit drug in exploring cross‐reactivity and identifying a possible cosensitization. A 2‐year‐old boy was treated with cefotaxime, vancomycin and metronidazole for acute otomastoiditis. Metronidazole was withdrawn and vancomycin was changed by teicoplanin 10 and 15 days later, respectively. Nineteen days after ongoing cefotaxime and 4 days after teicoplanin intake, the patient developed hyperthermia, a widespread exanthema, facial oedema with neither mucosal involvement nor palpable lymphadenopathy. Biological tests revealed eosinophilia, atypical lymphocytes, mild cytolysis and a high lactate dehydrogenase level. Serological tests for viral and bacterial infections were negative. DRESS was suspected and the 2 antibiotics were withdrawn. Intradermal tests (IDT) were carried out 2 months later with cefotaxime and teicoplanin. They revealed a positive result at 48‐hour reading. To assess cross‐reactivity among β‐lactams, IDT to penicillins (benzylpenicillin, amoxicillin and oxacillin) was performed showing negative results at 48‐hour reading. Nevertheless, IDT to cephalosporins (cefazolin, cefuroxime, ceftazidime and ceftriaxone) displayed positive results at 48‐hour reading. As a result, IDT are of great interest and should be performed to confirm the role of cefotaxime and detect a potential cross‐reactivity with chemically similar drugs and drugs taken before and during the episode of DRESS.

Drug reaction with eosinophilia and systemic symptoms in a paediatric population: Interest of skin tests

“…The same patient manifested a co‐sensitization to a chemically unrelated drug, that is, teicoplanin, which has never been implicated in multiple drug hypersensitivity. This case has been recently published, as it points out the role of skin tests in exploring cross‐reactivity and identifying a possible co‐sensitisation 44 . Cross‐reactivity between aromatic anticonvulsants has been previously described 45,46 .…”

“…This case has been recently published, as it points out the role of skin tests in exploring cross-reactivity and identifying a possible co-sensitisation. 44 Cross-reactivity between aromatic anticonvulsants has been previously described. 45,46 It is related to a common metabolite, arene oxid.…”