Cefepime vs. Ampicillin/Sulbactam and Aztreonam as antibiotic prophylaxis in neurosurgical patients with external ventricular drain: result of a prospective randomized controlled clinical trial

Abstract

Single board spectrum antibiotic prophylaxis with Cefepime was an effective alternative regimen for neurosurgical patients with an EVD in situ.

Rational antibiotic therapy and the position of ampicillin/sulbactam

“…AMS have been confirmed by numerous studies (mainly comparative) carried out in more recent years [30,[106][107][108][109][110][111][112][113][114][115][116][117] (Table 8). Thus, there is good evidence for AMS (typically given in one or more doses of 1-2 g ampicillin/0.5-1 g sulbactam i.v.…”

Infection rate and risk factors associated with infections related to external ventricular drain

“…The periprocedural administration of antibiotics with the aim of preventing ventriculostomy-related infections is not a completely resolved issue [12][13][14][15][16][17][18]. First-and second-generations cephalosporins have been used as prophylactic antibiotics for this procedure [19][20][21].…”

Clinical practice guidelines for antimicrobial prophylaxis in surgery

“…Data from most published clinical trials indicate that SSIs are primarily associated with gram-positive bacteria, S. aureus, and coagulase-negative staphylococci. 6,8,[537][538][539][540][541][542][543][544][545][547][548][549][550][551][552][553][554] Several cohort studies revealed high rates (up to 75-80% of isolates) of MRSA 540-543,548-552 and coagulasenegative staphylococci among patients undergoing a variety of neurosurgical procedures. 539,540,543,549 Other skin organisms such as P. acnes may be seen after CSF shunt placement, craniotomy, and other procedures.…”