Cefazolin Plasma Concentrations and Urinary Excretion in Patients with Renal Impairment

Pharmacokinetics and Clinical Use of Cephalosporin Antibiotics

“…The time of peak concentration after intramuscular administration was usually within 45 min to 1 hr after administration (44,. However, in several cases, the time of peak serum concentration appeared as late as 2 hr after administration (127,128).…”

“…Numerous pharmacokinetic studies have been performed using patients with normal kidney function (44, 70, 98, 99, 103-122, 127, 128, 134, 135) and impaired kidney function (98, 99,103,105,106,109,111,114,122,128,136). The range of half-lives reported for cefazolin after intravenous administration is 69-108 min (44,70,99,108,127,134), with an average of 88 min.…”

“…The renal and total body clearances of cefazolin have been studied (44,70,105,106,108,113,114,128,130). The plasma clearance found in one study was 61.5 f 6.1 ml/min and the renal clearance was 64.6 f 6.0 ml/min after either intravenous or intramuscular administration (44).…”

Pharmacokinetics of β-Lactam Antibiotics

“…The renal clearance of cefazolin correlated well with inulin clearance in a log-log fashion. CZERWINSKI et al (1974) found reasonable linear correlations between serum half-life and serum creatinine concentrations and between cefazolin renal clearance and creatinine clearance. Similar correlations were observed by BROGARD et al (1977b).…”

“…LEVISON et al (1973) and REIN et al (1973) administered a single 500-mg intramuscular dose of sodium cefazolin to patients with normal or abnormal renal function. Peak serum concentrations tended to increase slightly and serum drug levels persisted longer as kidney function decreased, especially as creatinine clearance dropped below 20 ml/min (CRAIG et al 1973;CZERWINSKI et al 1974). Recovery of drug in urine decreased as renal impairment increased.…”