CeF3-YF3-TbF3 Nanoparticle-Polymer–“Radachlorin” Conjugates for Combined Photodynamic Therapy: Synthesis, Characterization, and Biological Activity

Низамутдинов, А. С.; Lukinova, E.V.; Shamsutdinov, N.I.; Zelenikhin, P. V.; Khusainova, A. S.; Gafurov, Marat; Zinchenko, S. V.; Safin, Damir A.; Pudovkin, M.S.

doi:10.3390/jcs7060255

Cited by 5 publications

(2 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In turn, the temperature dependence of the luminescence signal should be known [2,3]. Among a huge variety of inorganic phosphors including oxides and quantum dots, rare-earth-doped fluoride nanoparticles pay a special role due to high chemical and mechanical stability, bright narrow luminescence peaks [4], and, in some cases low cytotoxicity [5,6]. Yttrium fluoride is considered very promising host-matrix due to low phonon energy (around 500 cm -1 ), which leads to the decrease in the non-radiative transition probability.…”

Section: Introductionmentioning

confidence: 99%

Spectral-Kinetic Characterization of YF3: Eu3+ and YF3: (Eu3+, Nd3+) Nanoparticles for Optical Temperature Sensing

Oleynikova,

Morozov,

Korableva

et al. 2024

Preprint

View full text Add to dashboard Cite

The YF3: (Eu3+, Nd3+) nanoparticles (orthorhombic phase, D ~ 130 nm)) were synthesized via the co-precipitation method with subsequent hydrothermal treatment and annealing. The Eu3+ τdecay linearly descends with the increase of temperature in the 80 - 320 K range. The τdecay (T) slope values of the annealed YF3: Eu3+ (2.5 and 5.0 mol. %) nanoparticles were the highest (110·10-4 and 67·10-4, μs/K in the whole 80 – 320 K range, respectively. Thus, these samples were chosen for further doping with Nd3+. The maximum Sa and Sr values based on the LIR (IEu/INd) function were 0.67 K-1 (at 80 K) and 0.86 %·K-1 (at 154 K), respectively. As it was mentioned above, the sin-gle-doped YF3: Eu3+ (2.5. %) nanoparticles showed the linearly decreasing τdecay (T) function (5D0 – 7F1 emission). The main idea of Nd3+ co-doping was to increase this slope value (as well as the sensitivity) by increasing the rate of τdecay (T) descent via the addition of one more tempera-ture-dependent channel of 5D0 excited state depopulation. Indeed, we managed to increase the slope (Sa) up to 180·10-4 K-1 at 80 K. This result is one of the highest compared to the world analogs.

show abstract

Section: Introductionmentioning

confidence: 99%

Spectral-Kinetic Characterization of YF3: Eu3+ and YF3: (Eu3+, Nd3+) Nanoparticles for Optical Temperature Sensing

Oleynikova,

Morozov,

Korableva

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…The reported approach allows for obtaining of hydrophilic uniform BaGdF 5 with tunable size (controlled by Ba and Gd precursor concentrations) in the range from 45 to 85 nm, which were obtained at temperatures as low as 120 • C and an aging time of 10 h. More recently, W. Liu and co-workers have reported a hydrothermal synthesis of BaGdF 5 :RE microcrystals and sub-micron particles of octahedral shape, where environmentally friendly ionic liquid 1-octyl-3-methylimidiazolium tetrafluoroborate ([Omim]BF 4 ) were employed as structure-driven agent [24]. Moreover, due to efficient, fast, and homogeneous heat transfer, microwave synthesis has been implemented for lanthanide fluoride synthesis [25][26][27]. In particular, Y. Lei and co-workers [28] have reported a microwaveassisted synthesis of fluorescent hydrophilic nanocrystals with BaYF 5 host matrix, while our group has previously implemented microwave treatment at 200 • C for obtaining Tb, Eu, and Sm-doped BaGdF 5 nanoparticles with a narrow size distribution [20].…”

Section: Introductionmentioning

confidence: 99%

Single-Stage Microfluidic Synthesis Route for BaGdF5:Tb3+-Based Nanocomposite Materials: Synthesis, Characterization and Biodistribution

Gadzhimagomedova,

Pankin,

Polyakov

et al. 2023

IJMS

Self Cite

View full text Add to dashboard Cite

Rare-earth-doped nanoscaled BaGdF5 is known as an efficient contrasting agent for X-ray micro-CT and NMR as well as a promising candidate for X-ray photodynamic therapy, thereby opening an opportunity for theragnostic applications. Conventional synthesis of Ln-doped BaGdF5 consider a long-lasting batch procedure, while a conjugation with photosensitizer usually implies a separate stage requiring active mixing. To the best of our knowledge, in this work, we for the first time obtain BaGdF5:Tb3+ nanophosphors in a microfluidic route at temperatures as low as 100 °C while decreasing the time of thermal treatment down to 6 min. The proposed synthesis route allows for the obtaining of single-phase and monodisperse BaGd1−xF5:Tbx3+ nanoparticles with an averaged particle size of ca. 7–9 nm and hydrodynamic radius around 22 nm, as estimated from TEM and DLS, respectively. In addition, X-ray-excited optical luminescence has been recorded in situ for the series of nanophosphors synthesis with varied flow rates of Tb3+ and Gd3+ stock solutions, thereby anticipating a possible application of microfluidics for screening a wide range of possible co-dopants and reaction conditions and its effect on the optical properties of the synthesized materials. Moreover, we demonstrated that BaGd1−xF5:Tbx3+@RoseBengal conjugates might be obtained in a single-stage route by implementing an additional mixer at the synthesis outcome, namely, by mixing the resulting reaction mixture containing nanoparticles with an equivalent flow of photosensitizer aqueous solution. In vitro cytotoxicity test declares moderate toxicity effect on different cell lines, while the results of flow cytometry indirectly confirm cellular uptake. Finally, we report long-term biodistribution monitoring of the synthesized nanocomposites assessed by X-ray micro-CT in the in vivo experiments on balb/c mice, which depicts an unusual character of agents’ accumulation.

show abstract

EPR and optical study of erbium-doped CeO2 and CeO2 / CeF3 nanoparticles

Pudovkin,

Morozov,

Korableva

et al. 2024

Ceramics International

View full text Add to dashboard Cite

CeF3-YF3-TbF3 Nanoparticle-Polymer–“Radachlorin” Conjugates for Combined Photodynamic Therapy: Synthesis, Characterization, and Biological Activity

Cited by 5 publications

References 34 publications

Spectral-Kinetic Characterization of YF3: Eu3+ and YF3: (Eu3+, Nd3+) Nanoparticles for Optical Temperature Sensing

Spectral-Kinetic Characterization of YF3: Eu3+ and YF3: (Eu3+, Nd3+) Nanoparticles for Optical Temperature Sensing

Single-Stage Microfluidic Synthesis Route for BaGdF5:Tb3+-Based Nanocomposite Materials: Synthesis, Characterization and Biodistribution

EPR and optical study of erbium-doped CeO2 and CeO2 / CeF3 nanoparticles

Contact Info

Product

Resources

About