CeCl3·7H2O: an efficient and reusable catalyst for the preparation of β-acetamido carbonyl compounds by multi-component reactions (MCRs)

Efficient Synthesis of β-Acetamido Ketones by Silver(I) Triflate-Catalyzed Multicomponent Reactions

“…Treatment of 4-methylacetophenone (1b) with benzaldehyde or arylaldehydes bearing electron-donating groups or electron-withdrawing groups on the benzene ring in acetonitrile for 6 h provided the desired products 4j-4m in 90-95% yield (entries 9-12). Similarly, reactions of 4-methoxyacetophenone (1c) with arylaldehydes bearing electrondonating groups or electron-withdrawing groups on the benzene ring in acetonitrile for 6 h gave β-acetamido ketones 4n-4q in 80-88% yield (entries [13][14][15][16]. Reaction of 1c with 1-naphthaldehyde and acetyl chloride in acetonitrile afforded product 4r in 96% yield (entry 17).…”

“…10 Recently, another new procedure for the formation of β-acetamido ketones through the MCRs of acetophenone, arylaldehyde, and acetyl chloride in acetonitrile has been developed. [11][12][13][14][15][16][17][18][19][20][21] This reaction has been extensively studied with the use of a variety of catalysts and reagents such as 20 and Amberlyst-15.…”

“…Although numerous methods for the synthesis of β-acetamido ketones have been reported, [11][12][13][14][15][16][17][18][19][20][21] there is still demand for simpler, less toxic, more effective, and milder catalysts. Our interest in developing a mild and efficient synthetic method that provides a variety of β-acetamido ketones has led us to looking into more convenient and safely usable catalysts.…”

Recent Developments in the Synthesis of β‐Amino Acids

“…On the other hand, Khans group [93] 2 -catalyzed cascade reaction of anilines with aromatic aldehydes and carbonyl compounds. This reaction was also applied to the synthesis of an a,b-amino carbonyl compound library on polyethylene glycol.…”

Methyl Acetoacetate: A Useful Reagent in Multicomponent Reactions

“…11,12 These compounds are valuable building blocks for the preparation of 1,3-amino alcohols or b-amino acids, as well as for the synthesis of various bioactive molecules. …”