Cecal Infusion of Sodium Propionate Promotes Intestinal Development and Jejunal Barrier Function in Growing Pigs

Zhang, Yanan; Chen, Huizi; Zhu, Weiyun; Yu, Kaifan

doi:10.3390/ani9060284

Cited by 17 publications

(12 citation statements)

References 45 publications

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“…Acetate and propionate are mainly transported to the liver through the portal vein and participate in energy metabolism ( 35 ). Recent research also revealed that propionate had positive effects on the intestinal development and barrier function of pigs ( 36 ). Therefore, the improved SCFA profile in TBZC group was able to provide additional energy available to weaned piglets and may be conducive to improving gut health.…”

Section: Discussionmentioning

confidence: 99%

Effects of Tetrabasic Zinc Chloride on Growth Performance, Nutrient Digestibility and Fecal Microbial Community in Weaned Piglets

Zhang

Hu²,

Yang³

et al. 2022

Front. Vet. Sci.

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The study was conducted to explore the effects of tetrabasic zinc chloride (TBZC), as an alternative to zinc oxide (ZnO), on growth performance, serum indexes, and fecal microbiota of weaned piglets. A total of 108 weaned piglets (average initial body weight of 7.84 ± 0.97 kg) were randomly allocated into one of three dietary treatments with six replicate pens and six piglets per pen. The dietary treatments included a control diet (CON, negative control), a ZnO diet (CON + 1,600 mg Zn/kg from ZnO, positive control), and a TBZC diet (CON + 1,000 mg Zn/kg from TBZC). The average daily gain of pigs in the TBZC group was greater (P < 0.05) than those in CON and ZnO groups during the whole period. Piglets fed the ZnO and TBZC diets showed lower (P < 0.05) diarrhea incidence than those fed the CON diet during d 1-14 and the whole period. Piglets fed the TBZC diet had higher (P < 0.05) digestibility of crude protein and gross energy than those fed the CON diet. Serum concentrations of IGF-I and GH, as well as ALP activity, were significantly elevated (P < 0.05) in the TBZC treatment group compared to the CON group on d 14. Piglets fed the ZnO diet had greater (P < 0.05) acetate and total short-chain fatty acids concentrations, while the TBZC diet had greater (P < 0.05) fecal acetate and propionate concentrations on d 28. Moreover, TBZC supplementation significantly increased (P < 0.05) microbial α-diversity compared with the CON group. The fecal microbiota of piglets in ZnO and TBZC treatment groups tended (P = 0.08) to have greater relative abundance of Prevotellaceae compared with the CON piglets. In conclusion, TBZC acted as a suitable alternative to ZnO to reduce zinc excretion, and improve growth performance of weaned piglets.

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Section: Discussionmentioning

confidence: 99%

Effects of Tetrabasic Zinc Chloride on Growth Performance, Nutrient Digestibility and Fecal Microbial Community in Weaned Piglets

Zhang

Hu²,

Yang³

et al. 2022

Front. Vet. Sci.

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“…Zhang et al demonstrated that an increase in propionate in the hindgut could contribute to intestinal development and enhancement of jejunal barrier integrity [ 39 ]. Furthermore, the increase in butyrate concentration in the large intestine could not only enhance animal growth but also improve the intestinal mucosal environment in weaned piglets and growing pigs [ 40 , 41 ].…”

Section: Discussionmentioning

confidence: 99%

Sophorolipid protects against early-weaning syndrome by improving the gut microenvironment in early-weaned piglets

Kwak

Choi

et al. 2022

BMC Vet Res

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Background In animals, weaning stress is the first and most critical stress. Weaning can negatively affect the growth performance of animals physically, psychologically, and pathologically. Our previous studies on the HT-29 cell line and early-weaned rats demonstrated that adequate sophorolipid (SPL) supplementation in feed could enhance the mucin-producing and wound healing capacities of the gut defense system by modulating gut microbiota. Methods We conducted an experiment with one hundred forty 21-day-old early weaned piglets (L x Y x D). They were allocated into 4 treatment and 7 replications (4 pigs per pen) according to their initial body weight. Body weight and feed intake were measured biweekly during experimental period. After 6 weeks, 28 pigs were randomly selected and sacrificed to collect plasma, jejunum, and cecal content samples. Results Dietary SPL supplementation at 5 and 10 mg/kg quadratically increased the average daily gain during the experimental period in the treatment groups when compared with the control group. The albumin levels of piglets fed with the SPL supplemented diet were downregulated to the normal range. Moreover, in feed, SPL supplementation at 5 and 10 mg/kg improved jejunal histological indices and gene expression levels related to mucin secretion and local inflammation markers. Consistent with these results, adequate SPL supplementation (5 and 10 mg/kg) increased the population of Prevotella, a beneficial bacterium, and its short-chain fatty acid production in the ceca of piglets. Conclusions The occurrence of diarrhea after weaning in piglets could be reduced by feeding a 10 ppm of SPL supplemented diet which improves the gut defense system by improving the microbial population and enhancing mucin layer integrity.

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“…Zhang et al demonstrated that an increase in propionate in the hindgut could contribute to intestinal development and enhancement of jejunal barrier integrity [30]. Furthermore, the increase in butyrate concentration in the large intestine could not only enhance animal growth but also improve the intestinal mucosal environment in weaned piglets and growing pigs [31][32].…”

Section: Discussionmentioning

confidence: 99%

Sophorolipid protects against early-weaning syndrome by improving the gut microenvironment in early-weaned piglets

Kwak

Choi

et al. 2021

Preprint

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Background In animals, weaning stress is the first and most critical stress. Weaning can negatively affect the growth performance of animals physically, psychologically, and pathologically. Our previous studies on the HT-29 cell line and early-weaned rats demonstrated that adequate sophorolipid (SPL) supplementation in feed could enhance the mucin-producing and wound healing capacities of the gut defense system by modulating gut microbiota. Results Dietary SPL supplementation at 5 and 10 mg/kg quadratically increased the average daily gain during the experimental period in the treatment groups when compared with the control group. The albumin levels of piglets fed with the SPL supplemented diet were downregulated to the normal range. Moreover, in feed, SPL supplementation at 5 and 10 mg/kg improved jejunal histological indices and gene expression levels related to mucin secretion and local inflammation markers. Consistent with these results, adequate SPL supplementation (5 and 10 mg/kg) increased the population of Lactobacillus, a beneficial bacteria, and its short-chain fatty acid production in the ceca of piglets. Conclusions The occurrence of diarrhea after weaning in piglets could be reduced by feeding an SPL-supplemented diet which improves the gut defense system by increasing the microbial population and enhancing mucin layer integrity.

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Cecal Infusion of Sodium Propionate Promotes Intestinal Development and Jejunal Barrier Function in Growing Pigs

Cited by 17 publications

References 45 publications

Effects of Tetrabasic Zinc Chloride on Growth Performance, Nutrient Digestibility and Fecal Microbial Community in Weaned Piglets

Effects of Tetrabasic Zinc Chloride on Growth Performance, Nutrient Digestibility and Fecal Microbial Community in Weaned Piglets

Sophorolipid protects against early-weaning syndrome by improving the gut microenvironment in early-weaned piglets

Sophorolipid protects against early-weaning syndrome by improving the gut microenvironment in early-weaned piglets

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