CEBPD modulates the airway smooth muscle transcriptomic response to glucocorticoids

Kan, Mengyuan; Sun, Maoyun; Jiang, Xiaofeng; Diwadkar, Avantika R.; Parikh, Vishal; Cao, Gaoyuan; Gebski, E.; Jester, William F.; Lan, Bo; Panettieri, Reynold A.; Koziol‐White, Cynthia; Lu, Quan; Himes, Blanca E.

doi:10.1186/s12931-022-02119-1

Cited by 3 publications

(2 citation statements)

References 41 publications

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“…1F and Supplemental Table 2). Conversely, target genes for GATA transcription factors and CCAAT enhancer binding protein delta (CEBPD), a positive transcriptional regulator of inflammatory responses mediated by interleukin-1 (IL-1) and IL-6 [40][41][42][43] , were enriched among transcripts upregulated in LDS VSMCs (Fig. 1G and Supplemental Table 2).…”

Section: Resultsmentioning

confidence: 99%

Intrinsic Gata4 expression sensitizes the aortic root to dilation in a Loeys-Dietz syndrome mouse model

Bramel,

Camejo,

Creamer

et al. 2024

Preprint

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Loeys-Dietz syndrome (LDS) is an aneurysm disorder caused by mutations that decrease transforming growth factor-β (TGF-β) signaling. Although aneurysms develop throughout the arterial tree, the aortic root is a site of heightened risk. To identify molecular determinants of this vulnerability, we investigated the heterogeneity of vascular smooth muscle cells (VSMCs) in the aorta of Tgfbr1M318R/+ LDS mice by single cell and spatial transcriptomics. Reduced expression of components of the extracellular matrix-receptor apparatus and upregulation of stress and inflammatory pathways were observed in all LDS VSMCs. However, regardless of genotype, a subset of Gata4-expressing VSMCs predominantly located in the aortic root intrinsically displayed a less differentiated, proinflammatory profile. A similar population was also identified among aortic VSMCs in a human scRNAseq dataset. Postnatal VSMC-specific Gata4 deletion reduced aortic root dilation in LDS mice, suggesting that this factor sensitizes the aortic root to the effects of impaired TGF-β signaling.

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Section: Resultsmentioning

confidence: 99%

Intrinsic Gata4 expression sensitizes the aortic root to dilation in a Loeys-Dietz syndrome mouse model

Bramel,

Camejo,

Creamer

et al. 2024

Preprint

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show abstract

“…The primary benefit of GWASs is their capability to carefully and objectively look into novel variants connected to a disease. GWASs, which have since 2007 found hundreds of genetic variants that may cause asthma, have enabled the creation of a systematic GWAS of disease vulnerability variations [ 31 ]. The very first GWAS on asthma that was carried out included 900 patients with asthma that started in infancy and 1,245 healthy controls with European ancestry.…”

Section: Reviewmentioning

confidence: 99%

A Multi-Point View of Genetic Factors Affecting Hereditary Transmissibility of Asthma

Kulkarni¹,

Kediya²

2022

Cureus

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Asthma is a respiratory illness characterized by episodes of bronchial spasm that make breathing difficult. It often has an association with an allergic response or any hypersensitivity followed by inflammation and hypersensitivity of the airways. Asthma is a sophisticated, complicated, and diverse respiratory condition. Even while heredity is a chief hazard factor for developing asthma, environmental and inner exposures, as well as how they interact with genetic variables, also have a substantial impact on the disease's pathogenesis. In recent years, the field of asthma research has seen the emergence and deployment of high throughput omics techniques for the unbiased screening of biomarkers such as genes, transcripts, proteins, and metabolites. Better asthma risk profile has been achieved by utilizing large-scale studies that are illustrative of various population-based data and merging with clinical data. This allergic airway illness has a wide range of phenotypes and endotypes, many of which have not yet been fully defined. The diversity of phenotypes is reflected in similarly complicated etiologies, and it is thought that a number of genetic and environmental variables interrelate to promote the danger of asthma in both children and adults. In order to achieve this objective, significant efforts are necessary to describe different phenotypes, uncover fundamental mechanisms, and find associated biomarkers. It is clear that the analysis, monitoring, and treatment of asthma require a tailored strategy. The risk of developing a multifactorial ailment is characterized by the grade of genetic relationship between the individual and affected relative. Additionally, the risk is typically larger if the relative has a severe illness or was afflicted when they were young. The asthma phenotype is highly varied and expressed non-linearly in contrast to single gene illnesses. This makes it challenging to predict whether someone with a certain gene or set of genotypes would have asthma.

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IL-2 family cytokines IL-9 and IL-21 differentially regulate innate and adaptive type 2 immunity in asthma

Bick,

Brenis Gómez,

Lammens

et al. 2024

Journal of Allergy and Clinical Immunology

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CEBPD modulates the airway smooth muscle transcriptomic response to glucocorticoids

Cited by 3 publications

References 41 publications

Intrinsic Gata4 expression sensitizes the aortic root to dilation in a Loeys-Dietz syndrome mouse model

Intrinsic Gata4 expression sensitizes the aortic root to dilation in a Loeys-Dietz syndrome mouse model

A Multi-Point View of Genetic Factors Affecting Hereditary Transmissibility of Asthma

IL-2 family cytokines IL-9 and IL-21 differentially regulate innate and adaptive type 2 immunity in asthma

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