CEACAM6 Impedes the HO-1-Mediated Defence Against Nitrosative/Oxidative Stress in COPD

Wu, Chengyu; Hadžić, Stefan; Dartsch, Ruth C.; Pak, Oleg; Wilhelm, J.; Wujak, Magdalena; Sommer, Natascha; Brosien, M.; Zhang, R.; Alkoudmani, Ibrahim; Witte, Biruta; Pederse, F.; Watz, H; Voswinckel, R.; Brandes, R.P.; Guenther, Andreas; Ghofrani, H.-A.; Schermuly, Ralph T.; Grimminger, F.; Seeger, W.; Weissmann, N.

doi:10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4629

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“…Despite considerable research into modeling asthma phenotypes and/or inflammatory milieu associated with asthma, there is a paucity of research into chronic obstructive pulmonary disease (COPD) using PCLS. To date, only four studies examining aspects of COPD pathobiology in hPCLS have been published [229][230][231][232][233]. Van Dijk et al reported that elastase-induced parenchymal disruption of murine PCLS that would provide an animal model to study COPD [234], and Kim et al defined the mechanical properties of PCLS derived from lungs from an emphysema patient [235].…”

Section: Table 2 Studies Of Airway Contraction/relaxationmentioning

confidence: 99%

Precision cut lung slices: an integrated ex vivo model for studying lung physiology, pharmacology, disease pathogenesis and drug discovery

Koziol-White,

Gebski,

Cao

et al. 2024

Respir Res

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Precision Cut Lung Slices (PCLS) have emerged as a sophisticated and physiologically relevant ex vivo model for studying the intricacies of lung diseases, including fibrosis, injury, repair, and host defense mechanisms. This innovative methodology presents a unique opportunity to bridge the gap between traditional in vitro cell cultures and in vivo animal models, offering researchers a more accurate representation of the intricate microenvironment of the lung. PCLS require the precise sectioning of lung tissue to maintain its structural and functional integrity. These thin slices serve as invaluable tools for various research endeavors, particularly in the realm of airway diseases. By providing a controlled microenvironment, precision-cut lung slices empower researchers to dissect and comprehend the multifaceted interactions and responses within lung tissue, thereby advancing our understanding of pulmonary pathophysiology.

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