CEA levels in serum and BAL in patients suffering from lung cancer

Charalabopoulos, Konstantinos; Karakosta, Agathi; Bablekos, George; Golias, Christos; Charalabopoulos, Alexandros; Tsanou, Eleni; Peschos, Dimitrios; Zoganas, L.; Batistatou, Anna

doi:10.1007/bf02698043

Cited by 21 publications

(15 citation statements)

References 17 publications

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“…[15] Unlike CEA, DR-70 floats freely in blood and abundant in serum acts as a “barometer for cancer” by simultaneously measuring the multiple FDP species that may be underestimated by other tests. [161718] DR-70 detects all of the breakdown products of Fibrin and Fibrinogen, including a unique “IPDP” cancer-related breakdown product. DR-70 is different from estimation of D-dimer as D-dimer values alone would greatly underestimate cancer and miss some altogether.…”

Section: Discussionmentioning

confidence: 99%

Role of DR-70 immunoassay in suspected malignant pleural effusion

et al. 2013

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Context:A good proportion of patients with undiagnosed pleural effusion (PE) turn into malignancy over a period of time. Identification of positive biomarker may help in selecting the individuals who require close follow-up.Aims:The aims of this study were to evaluate the role of DR-70 immunoassay in suspected malignant PE.Settings and Design:We conducted a cross-sectional study among 89 patients of suspected malignant PE and 50 normal subjects (NS) were taken as control.Materials and Methods:Patients with exudative PE; who had pleural fluid lymphocyte count greater than 50% and adenosine deaminase less than 30 U/L were taken as cases. We had selected NSs among relatives of patients having normal blood chemistry and radiological investigations. Sensitivity and specificity of the test to differentiate malignant and non-malignant PE and also to identify PE with underlying malignancy was analyzed.Results:Mean value of DR-70 in NS was found to be 0.83 ± 0.273 mg/L without any significant difference between males (0.82 mg/L) and females (0.85 mg/L). Mean value of DR-70 in PE with underlying cancer was 5.03 ± 3.79 mg/L. Sensitivity (80%) and specificity (77.78%) of the test was maximum in PE with underlying cancer using cut-off value of 2 mg/L. Mean value DR-70 in malignant PE was 5.18 ± 3.75 mg/L and in non-malignant PE was 3.73 ± 3.74 mg/L without any statistically significant difference (P = 0.08).Conclusions:DR-70 assay has high sensitivity in detecting underlying lung cancer, but has no role in differentiating malignant PE from non-malignant PE.

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Section: Discussionmentioning

confidence: 99%

Role of DR-70 immunoassay in suspected malignant pleural effusion

et al. 2013

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“…Investigating specific molecular markers in airways might serve as an important adjunct to routine examination for lung cancer diagnosis. The utility of cytokines in bronchoalveolar lavage fluid (BALF) for differential diagnosis of lung cancer has been described in several studies6789101112. In our previous reports, we also observed that the levels of vascular endothelial growth factor (VEGF) and neuron-specific enolase (NSE) were significantly higher in BALF of lung cancer patients than in that of patients with benign diseases1314.…”

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confidence: 90%

TGF-β1, IL-6 and TNF-α in Bronchoalveolar Lavage Fluid: Useful Markers for Lung Cancer?

Chen

Sun

et al. 2014

Sci Rep

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Changes of cytokines in bronchoalveolar lavage fluid (BALF) reflect immunologic reactions of the lung in pulmonary malignancies. Detection of biomarkers in BALF might serve as an important method for differential diagnosis of lung cancer. A total of 78 patients admitted into hospital with suspected lung cancer were included in our study. BALF samples were obtained from all patients, and were analyzed for TGF-β1, IL-6, and TNF-α using commercially available sandwich ELISA kits. The levels of TGF-β1 in BALF were significantly higher in patients with lung cancer compared with patients with benign diseases (P = 0.003). However, no significant difference of IL-6 (P = 0.61) or TNF-α (P = 0.72) in BALF was observed between malignant and nonmalignant groups. With a cut-off value of 10.85 pg/ml, TGF-β1 showed a sensitivity of 62.2%, and a specificity of 60.6%, in predicting the malignant nature of pulmonary disease. Our data suggest that TGF-β1 in BALF might be a valuable biomarker for lung cancer. However, measurement of IL-6 or TNF-α in BALF has poor diagnostic value in lung cancer.

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“…In contrast, only a few studies have investigated CEA concentrations in BALF. Charalabopoulos et al 10 measured CEA in BALF among 50 patients with lung cancer, 20 benign lung lesions, and 20 healthy controls. In support of our findings, they demonstrated that CEA measurement in BALF alone has little value in the diagnosis of malignancy.…”

Section: Disscusionmentioning

confidence: 99%

“…Changes of cytokines in bronchoalveolar lavage fluid (BALF) reflect immunologic reactions of the lung in pulmonary malignancies4. Thus, detection of biomarkers in BALF might serve as an important adjunct to bronchoscopy for differential diagnosis of lung cancer567891011. In our previous study, we found that the level of vascular endothelial growth factor (VEGF) was significantly increased in both serum and BALF among patients with lung cancer12.…”

mentioning

confidence: 99%

Evaluation of VEGF-C and Tumor Markers in Bronchoalveolar Lavage Fluid for Lung Cancer Diagnosis

Cao

Chen

Sun

et al. 2013

Sci Rep

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A total of 87 patients were enrolled and bronchoalveolar lavage fluid (BALF) samples were obtained from all subjects. A significant difference was found in BALF VEGF-C level between patients with squamous cell carcinoma and benign diseases (P = 0.043). In addition, the concentration of NSE in BALF form the malignant group was significantly higher compared with that of the benign groups (P = 0.018). However, no statistical difference was observed in BALF CEA (P = 0.375) or CYFRA21-1 (P = 0.838) between lung cancer patients and nonmalignant controls. With a cut-off value of 2.06 ng/ml, NSE had a sensitivity of 72.9%, a specificity of 69.2%, respectively, in predicting the malignant nature of pulmonary mass. Our study observed that the level of VEGF-C was increased in BALF of patients with squamous cell carcinoma. Moreover, we found that NSE was significantly higher in BALF of lung cancer patients than in benign diseases.

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CEA levels in serum and BAL in patients suffering from lung cancer

Cited by 21 publications

References 17 publications

Role of DR-70 immunoassay in suspected malignant pleural effusion

Role of DR-70 immunoassay in suspected malignant pleural effusion

TGF-β1, IL-6 and TNF-α in Bronchoalveolar Lavage Fluid: Useful Markers for Lung Cancer?

Evaluation of VEGF-C and Tumor Markers in Bronchoalveolar Lavage Fluid for Lung Cancer Diagnosis

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