CE: Trauma-Related Hemorrhagic Shock: A Clinical Review

Caldwell, Nicole; Suresh, Mithun R; Garcia-Choudary, Tricia; VanFosson, Christopher A

doi:10.1097/01.naj.0000697640.04470.21

Cited by 11 publications

(9 citation statements)

References 43 publications

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“…The emergency rescue and nursing model enhances the requirements of nursing staff to a certain extent. The nursing staff not only needs to have professional theoretical skills but also needs to have skilled operation ability and high sense of responsibility to treat and care for them in the shortest time, so as to reduce the incidence of complications [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

The Value of Emergency Nursing Mode in the Treatment of Patients with Traumatic Shock

Jin-mei

Zhou

Wang

et al. 2022

Journal of Healthcare Engineering

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Objective. To study the value of emergency nursing mode in patients with traumatic shock. Methods. 76 patients with traumatic shock in our hospital from March 2019 to February 2021 were selected and divided into study group and control group according to different rescue modes, 38 cases in each group. The study group adopted emergency nursing mode for rescue, while the control group adopted routine nursing mode for rescue. The rescue intervention, emergency stay and preoperative preparation time, rescue success rate, emergency rescue effect, complications, and satisfaction rate of patients and their families for rescue were compared between the two groups. Results. The rescue intervention, emergency stay and preoperative preparation time of the study group were significantly shorter than those of the control group, and the difference was statistically significant ( P < 0.05 ). The rescue success rate of the study group was 97.37%, which was significantly higher than 84.21% of the control group, and the difference was statistically significant ( P < 0.05 ). The improvement rate of the study group was significantly higher than that of the control group, the disability rate was significantly lower than that of the control group, the overall emergency rescue effect was better than that of the control group, and the difference was statistically significant ( P < 0.05 ). The incidence of complications in the study group was 2.63%, which was significantly lower than 23.68% in the control group ( P < 0.05 ). The satisfaction rate of patients and their families in the study group was 97.37%, which was significantly higher than 84.21% in the control group ( P < 0.05 ). Conclusion. Emergency nursing mode in patients with traumatic shock owns higher rescue value, can buy time for the operation, improve the success rate and effect of rescue, make safety and satisfaction higher. Overall, for patients with traumatic shock, emergency nursing mode is better than conventional rescue nursing.

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Section: Discussionmentioning

confidence: 99%

The Value of Emergency Nursing Mode in the Treatment of Patients with Traumatic Shock

Jin-mei

Zhou

Wang

et al. 2022

Journal of Healthcare Engineering

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“…(4) Hypovolemic shock in the needlelike sensation, sequencing from a hypercritical decrement in perfusing plasma volume without dangerous hemorrhage. (3) Traumatic hypovolemic shock, sequencing from a hypercritical suppression in perfusing plasma volume without serious hemorrhage, owing to soft tissue affliction and the delivery of immune system conciliators [5,7]. Treatment: The preclinical and clinical management of hypovolemic shock contains of instantaneous intravascular volume substitution with equilibrium crystalloids using broad-bore peripheral venous access and, in a long suffering that is hemorrhaging, hast bleeding restrain [5]; supplemental O 2 ; supine position.…”

Section: Hypovolemic Shockmentioning

confidence: 99%

Shock: Pathophysiology, Stage, Classification, and Treatment

Bereda¹

2021

PLM

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Shock is a state of resulting from an indented state of multiple important body works owing to decreased tissue perfusion. It is a circumstance that could menace life. Progressive stage of shock means failing compensatory mechanisms and the body's compensatory mechanisms weaken to vindicate tissue perfusion. Hypovolemic shock is a circumstance of insufficient organ perfusion caused by destruction of intravascular volume, ordinarily acute. Distributive shock is a state of comparative hypovolemia sequencing from affiliated to pathology spread to other areas of the perfect intravascular volume and is more common form of shock. Dextran has considerable merits over distinctive types of colloids for the initial shock treatment owing to its antithrombotic properties whereby cell satisfactory is obviated and the occurrence of systematic circulations is decisively de-escalated. Drugs that de-escalate the hearts workload and pain such as morphine or fentanyl relieve anxiety or regulate heart rhythm. Vasopressor medications such as dopamine, norepinephrine, which are medications that constrict blood vessels and assists, escalate blood pressure. High amount of IV fluids very quickly and bestowing medications that will escalate the blood pressure to escalate blood flow to the rest of the body and organs.

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“…Hypovolemic shock occurs when severe dehydration or the loss of blood caused by medical malpractice or trauma, which leaves the vascular system with insufficient blood volume and thus severely reduction in perfusion pressure. This hypovolemic shock due to the loss of blood is called hemorrhagic shock (HS) (1). The immune dysfunction caused by HS is an important cause of death in patients.…”

Section: Introductionmentioning

confidence: 99%

TLR2/TLR4-Enhanced TIPE2 Expression Is Involved in Post-Hemorrhagic Shock Mesenteric Lymph-Induced Activation of CD4+T Cells

Jiang

Zhao

et al. 2022

Front. Immunol.

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PurposePost hemorrhagic shock mesenteric lymph (PHSML) return contributes to CD4+ T cell dysfunction, which leads to immune dysfunction and uncontrolled inflammatory response. Tumor necrosis factor α induced protein 8 like-2 (TIPE2) is one of the essential proteins to maintain the immune homeostasis. This study investigated the role of TIPE2 in regulation of CD4+ T lymphocyte function in interaction of PHSML and TLR2/TLR4.MethodsThe splenic CD4+ T cells were isolated from various mice (WT, TLR2-/-, TLR4-/-) by immunomagnetic beads, and stimulated with PHSML, normal lymphatic fluid (NML), respectively. Application of TIPE2-carrying interfering fragments of lentivirus were transfected to WT, TLR4-/-, and TLR2-/- CD4+ T cells, respectively. After interference of TIPE2, they were stimulated with PHSML and NML for the examinations of TIPE2, TLR2, and TLR4 mRNA expressions, proliferation, activation molecules on surface, and cytokine secretion function.ResultsPHSML stimulation significantly upregulated TIPE2, TLR2, and TLR4 mRNA expressions, decreased proliferation, CD25 expression, and IFN-γ secretion, and increased the secretion ability of IL-4 in WT CD4+ T cells. TIPE2 silencing enhanced proliferative capacity, upregulated CD25 expression, and increased IFNγ secretion in CD4+ T cells. PHSML stimulated TLR2-/-CD4+ T or TLR4-/-CD4+ T cells of which TIPE2 were silenced. TLR2 or TLR4 knockout attenuated PHSML-induced CD4+ T cells dysfunction; PHSML stimulation of silent TIPE2-expressing TLR2-/-CD4+ T or TLR4-/-CD4+ T revealed that the coexistence of low TIPE2 expression with lack of TLR2 or TLR4 eliminated this beneficial effect.ConclusionTIPE2 improves the PHSML-mediated CD4+T cells dysfunction by regulating TLR2/TLR4 pathway, providing a new intervention target following hemorrhagic shock-induced immune dysfunction.

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CE: Trauma-Related Hemorrhagic Shock: A Clinical Review

Cited by 11 publications

References 43 publications

The Value of Emergency Nursing Mode in the Treatment of Patients with Traumatic Shock

The Value of Emergency Nursing Mode in the Treatment of Patients with Traumatic Shock

Shock: Pathophysiology, Stage, Classification, and Treatment

TLR2/TLR4-Enhanced TIPE2 Expression Is Involved in Post-Hemorrhagic Shock Mesenteric Lymph-Induced Activation of CD4+T Cells

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