CDX2 dose-dependently influences the gene regulatory network underlying human extraembryonic mesoderm development
Emily A. Bulger,
Todd C. McDevitt,
Benoit G. Bruneau
Abstract:Proper regulation of gene dosage is critical for the development of the early embryo and the extraembryonic tissues that support it. Specifically, loss of Cdx2 in vivo leads to stunted development of the allantois, an extraembryonic mesoderm-derived structure critical for nutrient delivery and waste removal in the early embryo. In this study, we investigate how CDX2 dose-dependently influences the gene regulatory network underlying extraembryonic mesoderm development. We generate an allelic series for CDX2 in … Show more
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