CdTe and CdZnTe detectors in nuclear medicine

Scheiber, C.

doi:10.1016/s0168-9002(00)00282-5

Cited by 70 publications

(48 citation statements)

References 39 publications

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“…High energy resolution and flexibility in both the sizing and the fine arrangement of detectors are expected to improve image quality. These characteristics of semiconductor detectors may also lead to improved PET images because the high energy resolution offers a reduction in scatter noise, like that seen with g-camera and SPECT applications (1,3).…”

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confidence: 99%

A New PET Scanner with Semiconductor Detectors Enables Better Identification of Intratumoral Inhomogeneity

Shiga

Morimoto²,

Kubo³

et al. 2008

J Nucl Med

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An autoradiography method revealed intratumoral inhomogeneity in various solid tumors. It is becoming increasingly important to estimate intratumoral inhomogeneity. However, with low spatial resolution and high scatter noise, it is difficult to detect intratumoral inhomogeneity in clinical settings. We developed a new PET system with CdTe semiconductor detectors to provide images with high spatial resolution and low scatter noise. Both phantom images and patients' images were analyzed to evaluate intratumoral inhomogeneity. Methods: This study was performed with a cold spot phantom that had 6-mm-diameter cold sphenoid defects, a dual-cylinder phantom with an adjusted concentration of 1:2, and an ''H''-shaped hot phantom. These were surrounded with water. Phantom images and 18 F-FDG PET images of patients with nasopharyngeal cancer were compared with conventional bismuth germanate PET images. Profile curves for the phantoms were measured as peak-to-valley ratios to define contrast. Intratumoral inhomogeneity and tumor edge sharpness were evaluated on the images of the patients. Results: The contrast obtained with the semiconductor PET scanner (1.53) was 28% higher than that obtained with the conventional scanner (1.20) for the 6-mm-diameter cold sphenoid phantom. The contrast obtained with the semiconductor PET scanner (1.43) was 27% higher than that obtained with the conventional scanner (1.13) for the dual-cylinder phantom. Similarly, the 2-mm cold region between 1-mm hot rods was identified only by the new PET scanner and not by the conventional scanner. The new PET scanner identified intratumoral inhomogeneity in more detail than the conventional scanner in 6 of 10 patients. The tumor edge was sharper on the images obtained with the new PET scanner than on those obtained with the conventional scanner. Conclusion: These phantom and clinical studies suggested that this new PET scanner has the potential for better identification of intratumoral inhomogeneity, probably because of its high spatial resolution and low scatter noise. PET with 18 F-FDG has been widely used in oncology studies. A high-resolution PET camera permits precise evaluation of tumor localization and treatment effects. Recently, CdTe semiconductors were used for the direct conversion of g-rays without scintillator material (1,2). High energy resolution and flexibility in both the sizing and the fine arrangement of detectors are expected to improve image quality. These characteristics of semiconductor detectors may also lead to improved PET images because the high energy resolution offers a reduction in scatter noise, like that seen with g-camera and SPECT applications (1,3).A depth-of-interaction (DOI) detection system has already been used in some PET scanners, particularly in PET scanners dedicated to use for the human brain. This is because DOI information is very useful for reducing the parallax errors at the periphery of the field of view (FOV) (4,5). With both semiconductor detectors and a DOI system, high-quality PET images with low scat...

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confidence: 99%

A New PET Scanner with Semiconductor Detectors Enables Better Identification of Intratumoral Inhomogeneity

Shiga

Morimoto²,

Kubo³

et al. 2008

J Nucl Med

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“…CdTe pixelated semiconductor materials have been studied for their applications in nuclearmedicine imaging. The useful properties of CdTe include its wide band gap, high atomic number, and good charge transport [22][23][24].…”

Section: Pid 350 Cdte Psdmentioning

confidence: 99%

A Numerical Study of Different Types of Collimators for a High-Resolution Preclinical CdTe Pixelated Semiconductor SPECT System

Jeong

Kim

Bae

et al. 2016

Journal of the Optical Society of Korea

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In single-photon-emission computed tomography (SPECT) with a pixelated semiconductor detector (PSD), not only pinhole collimators but also parallel-hole collimators are often used in preclinical nuclear-medicine imaging systems. The purpose of this study was to evaluate and compare pinhole and parallel-hole collimators in a PSD. For that purpose, we paired a PID 350 (Ajat Oy Ltd., Finland) CdTe PSD with each of the four collimators most frequently used in preclinical nuclear medicine: (1) a pinhole collimator, and (2) low-energy high-resolution (LEHR), (3) low-energy general-purpose (LEGP), and (4) low-energy high-sensitivity (LEHS) parallel-hole collimators. The sensitivity and spatial resolution of each collimator was evaluated using a point source and a hot-rod phantom. The highest sensitivity was achieved using LEHS, followed by LEGP, LEHR, and pinhole. Also, at a source-to-collimator distance of 2 cm, the spatial resolution was 1.63, 2.05, 2.79, and 3.45 mm using pinhole, LEHR, LEGP, and LEHS, respectively. The reconstructed hot-rod phantom images showed that the pinhole collimator and the LEHR parallel-hole collimator give a fine spatial resolution for preclinical SPECT with PSD. In conclusion, we successfully compared different types of collimators for a preclinical pixelated semiconductor SPECT system.

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“…In current SPECT scanners, cadmium zinc telluride (CZT) semiconductor detectors have been applied to improve energy and spatial resolution [4][5][6][7][8], as compared with sodium iodide (NaI) scintillation detectors, which were used in conventional SPECT scanners [9][10][11][12][13][14][15][16][17][18][19]. Planar and SPECT projection data are acquired using various collimators in clinical settings.…”

Section: Introductionmentioning

confidence: 99%

Appropriate collimators in a small animal SPECT scanner with CZT detector

et al. 2013

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word count: 268; Total word count: 3238 Short title: Comparison of collimators Abstract ObjectiveAlmost all small-animal SPECT is performed with pinhole collimators (PH), including single-PH (SPH) and multi-PH (MPH). In the clinical study, not only PH but also parallel-hole collimator (PAH) is often used in planar and SPECT imaging.However, there have been no comparative studies on image quality with various collimators on the small-animal imaging.This study compared the basic characteristics of PH and PAH in small-animal imaging. MethodsPerformance of planar and SPECT imaging were evaluated using 99mTcO 4 -and SPH, MPH and PAH with low energy and high resolution on the SPECT/CT scanner FX3200.We measured sensitivity, resolution, concentration linearity and uniformity. Tc-MDP-SPECT images than SPH and PAH. ConclusionsThe characteristics of PH and PAH differed on small-animal imaging. Although sensitivity was higher with PAH, PH showed higher resolution. Among the PH collimators, SPH was more appropriate for planar imaging, and MPH was more suitable for SPECT imaging in a small animal imaging scanner with CZT detector.

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CdTe and CdZnTe detectors in nuclear medicine

Cited by 70 publications

References 39 publications

A New PET Scanner with Semiconductor Detectors Enables Better Identification of Intratumoral Inhomogeneity

A New PET Scanner with Semiconductor Detectors Enables Better Identification of Intratumoral Inhomogeneity

A Numerical Study of Different Types of Collimators for a High-Resolution Preclinical CdTe Pixelated Semiconductor SPECT System

Appropriate collimators in a small animal SPECT scanner with CZT detector

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