CDK9 modulates circadian clock by attenuating REV-ERBα activity

Ou, Jiali; Li, Huilin; Qiu, Peiyuan; Li, Qing; Chang, Hung-Chun; Tang, Yun‐Chi

doi:10.1016/j.bbrc.2019.04.043

Cited by 12 publications

(5 citation statements)

References 29 publications

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“…A loss of PER1 in tumor cells therefore removes a regulatory component of the cell cycle [7]. The relationship between cell cycle and circadian rhythms can also behave bidirectionally, for example, cyclin-dependent kinase 9 (CDK9) can modulate the clock by attenuating REV-ERBα activity [140].…”

Section: Disrupted Cell Cycles Can Be Controlled By Circadian Rhythmsmentioning

confidence: 99%

The Cancer Clock Is (Not) Ticking: Links between Circadian Rhythms and Cancer

et al. 2019

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Circadian rhythms regulate many physiological and behavioral processes, including sleep, metabolism and cell division, which have a 24-h oscillation pattern. Rhythmicity is generated by a transcriptional–translational feedback loop in individual cells, which are synchronized by the central pacemaker in the brain and external cues. Epidemiological and clinical studies indicate that disruption of these rhythms can increase both tumorigenesis and cancer progression. Environmental changes (shift work, jet lag, exposure to light at night), mutations in circadian regulating genes, and changes to clock gene expression are recognized forms of disruption and are associated with cancer risk and/or cancer progression. Experimental data in animals and cell cultures further supports the role of the cellular circadian clock in coordinating cell division and DNA repair, and disrupted cellular clocks accelerate cancer cell growth. This review will summarize studies linking circadian disruption to cancer biology and explore how such disruptions may be further altered by common characteristics of tumors including hypoxia and acidosis. We will highlight how circadian rhythms might be exploited for cancer drug development, including how delivery of current chemotherapies may be enhanced using chronotherapy. Understanding the role of circadian rhythms in carcinogenesis and tumor progression will enable us to better understand causes of cancer and how to treat them.

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Section: Disrupted Cell Cycles Can Be Controlled By Circadian Rhythmsmentioning

confidence: 99%

The Cancer Clock Is (Not) Ticking: Links between Circadian Rhythms and Cancer

et al. 2019

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“…Most of the inhibitors, particularly LH846, D4476, and SU9516, led to a substantial dose-dependent increase in the period length (Fig 4). Whereas LH846, D4476, and BS-181 have previously been reported to induce period lengthening (Hirota et al, 2010; Lee et al, 2011; Ou et al, 2019), the other inhibitors were not known to have circadian period–modulating ability. Notably, we also observed dose-dependent phase-shifting effects of KY-05009, SU9516, BS-181 HCl, and D4476 (Fig S7).…”

Section: Resultsmentioning

confidence: 93%

Phenotypic proteomic profiling identifies a landscape of targets for circadian clock–modulating compounds

Lach

Heesom

et al. 2019

Life Sci. Alliance

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“…Oshima et al ( Oshima et al, 2019 ) conducted a proteomic analysis and identified that the CKⅡ inhibitor GO289 inhibited the PER2 phosphorylation sites, leading to extended circadian rhythms and suppressed growth in kidney cancer and acute myeloid leukemia cells. LY2857785, a CDK9 inhibitor, has been shown to decrease core clock protein levels including BMAL1 and PER2, by upregulating REV-ERBα expression ( Ou et al, 2019 ). Additionally, mutations of PER2 could shorten circadian rhythms in mice induced by N-ethyl-N-nitrosourea (ENU) in the PAS domain, suggesting the PAS domain as target within the PER gene family for future interventions ( Militi et al, 2016 ).…”

Section: The Per Gene Family-related Drugsmentioning

confidence: 99%

Biological clock regulation by the PER gene family: a new perspective on tumor development

Chen,

Wang,

et al. 2024

Front. Cell Dev. Biol.

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The Period (PER) gene family is one of the core components of the circadian clock, with substantial correlations between the PER genes and cancers identified in extensive researches. Abnormal mutations in PER genes can influence cell function, metabolic activity, immunity, and therapy responses, thereby promoting the initiation and development of cancers. This ultimately results in unequal cancers progression and prognosis in patients. This leads to variable cancer progression and prognosis among patients. In-depth studies on the interactions between the PER genes and cancers can reveal novel strategies for cancer detection and treatment. In this review, we aim to provide a comprehensive overview of the latest research on the role of the PER gene family in cancer.

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CDK9 modulates circadian clock by attenuating REV-ERBα activity

Cited by 12 publications

References 29 publications

The Cancer Clock Is (Not) Ticking: Links between Circadian Rhythms and Cancer

The Cancer Clock Is (Not) Ticking: Links between Circadian Rhythms and Cancer

Phenotypic proteomic profiling identifies a landscape of targets for circadian clock–modulating compounds

Biological clock regulation by the PER gene family: a new perspective on tumor development

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