CDK11p46 and RPS8 associate with each other and suppress translation in a synergistic manner

Hao, Yuqing; Kong, Xue; Ruan, Yuanyuan; Gan, Huachen; Chen, Hong; Zhang, Chunyi; Ren, Shifang; Gu, Jianxin

doi:10.1016/j.bbrc.2011.02.132

Cited by 20 publications

(18 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Two of the ribosomal proteins, RPS8 and RPL3 have been reported to be involved in modulation of apoptosis sensitivity [36,37]. RPS6 and RPL5 are involved in stress signaling or hypoxia response [38–41].…”

Section: Discussionmentioning

confidence: 99%

Epsin Family Member 3 and Ribosome-Related Genes Are Associated with Late Metastasis in Estrogen Receptor-Positive Breast Cancer and Long-Term Survival in Non-Small Cell Lung Cancer Using a Genome-Wide Identification and Validation Strategy

et al. 2016

View full text Add to dashboard Cite

BackgroundIn breast cancer, gene signatures that predict the risk of metastasis after surgical tumor resection are mainly indicative of early events. The purpose of this study was to identify genes linked to metastatic recurrence more than three years after surgery.MethodsAffymetrix HG U133A and Plus 2.0 array datasets with information on metastasis-free, disease-free or overall survival were accessed via public repositories. Time restricted Cox regression models were used to identify genes associated with metastasis during or after the first three years post-surgery (early- and late-type genes). A sequential validation study design, with two non-adjuvantly treated discovery cohorts (n = 409) and one validation cohort (n = 169) was applied and identified genes were further evaluated in tamoxifen-treated breast cancer patients (n = 923), as well as in patients with non-small cell lung (n = 1779), colon (n = 893) and ovarian (n = 922) cancer.ResultsTen late- and 243 early-type genes were identified in adjuvantly untreated breast cancer. Adjustment to clinicopathological factors and an established proliferation-related signature markedly reduced the number of early-type genes to 16, whereas nine late-type genes still remained significant. These nine genes were associated with metastasis-free survival (MFS) also in a non-time restricted model, but not in the early period alone, stressing that their prognostic impact was primarily based on MFS more than three years after surgery. Four of the ten late-type genes, the ribosome-related factors EIF4B, RPL5, RPL3, and the tumor angiogenesis modifier EPN3 were significantly associated with MFS in the late period also in a meta-analysis of tamoxifen-treated breast cancer cohorts. In contrast, only one late-type gene (EPN3) showed consistent survival associations in more than one cohort in the other cancer types, being associated with worse outcome in two non-small cell lung cancer cohorts. No late-type gene was validated in ovarian and colon cancer.ConclusionsRibosome-related genes were associated with decreased risk of late metastasis in both adjuvantly untreated and tamoxifen-treated breast cancer patients. In contrast, high expression of epsin (EPN3) was associated with increased risk of late metastasis. This is of clinical relevance considering the well-understood role of epsins in tumor angiogenesis and the ongoing development of epsin antagonizing therapies.

show abstract

Section: Discussionmentioning

confidence: 99%

Epsin Family Member 3 and Ribosome-Related Genes Are Associated with Late Metastasis in Estrogen Receptor-Positive Breast Cancer and Long-Term Survival in Non-Small Cell Lung Cancer Using a Genome-Wide Identification and Validation Strategy

et al. 2016

View full text Add to dashboard Cite

show abstract

“…CDK11 (formerly known as PITSLRE or CDC2L1) is a member of the extended family of p34cdc2-related kinases [18]. At least 10 CDK11 isoforms have been cloned in eukaryotic cells, and the major isoforms are CDK11 p110 [19,20], CDK11 p58 [21,22], and CDK11 p46 [23]. Although no clear mechanistic functions for CDK11 are known in tumor cells, the larger CDK11 p110 isoform has been reported to have effects on the regulation of transcription and RNA splicing [24–26].…”

Section: Introductionmentioning

confidence: 99%

Cyclin-dependent kinase 11 (CDK11) is crucial in the growth of liposarcoma cells

et al. 2014

View full text Add to dashboard Cite

Liposarcoma is the second most common soft tissue sarcoma in adults, but treatment options have been quite limited thus far. In this study, we investigated the functional and therapeutic relevance of cyclin-dependent kinase 11 (CDK11) as a putative target in liposarcoma. CDK11 knockdown by synthetic siRNA or lentiviral shRNA decreased cell proliferation, and induced apoptosis in liposarcoma cells. Moreover, CDK11 knockdown enhances the cytotoxic effect of doxorubicin to inhibit cell growth in liposarcoma cells. These findings suggest that CDK11 is critical for the growth and proliferation of liposarcoma cells. CDK11 may be a promising therapeutic target for the treatment of liposarcoma patients.

show abstract

“…In the context of the hub genes of the PPI network based on ARVC vs. DCM, RPS3A was a key factor in modulating the brown fat-speci c gene UCP-1 and carbon metabolic enzymes in EAT for preventing CAD [54]. CDK11p46 and RPS8 are associated with each other, and both are involved in cell apoptosis; similarly, over-expression of RPS14 can inhibit Rb phosphorylation and result in cell cycle arrest and senescence [55,56]. It is well known that diabetes and renal dysfunction can both affect cardiac function, but interestingly, RPS12 has been identi ed as a pathogenic gene of diabetic kidney disease by a genome-wide association study (GWAS) [57].…”

Section: Hub Genes Of the Ppi Networkmentioning

confidence: 99%

Identification Of Both Shared And Specific Potential Molecular Mechanisms Of Arvc And Dcm Based On A Genome-Wide Microarray Dataset

Zhang

Guan

Líu³

2020

Preprint

View full text Add to dashboard Cite

Background: The study aimed to detect the shared differentially expressed genes (DEGs) and specific DEGs of arrhythmogenic right ventricular cardiomyopathy (ARVC) and dilated cardiomyopathy (DCM) as well as their pathways.Methods: The GSE29819 dataset was examined for the DEGs of ARVC vs. non-failing transplant donor hearts (NF), DCM vs. NF, and ARVC vs. DCM based on 6 patients with ARVC, 7 patients with DCM, and 6 non-failing transplant donor hearts that were never actually transplanted. The shared DEGs and specific DEGs were screened out using a Venn diagram. The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment, Gene Ontology (GO) annotation, and protein-protein interaction (PPI) of the DEGs were determined using online analytical tools. Then, the modules and hub genes were identified using Cytoscape software.Results: A total of 684 shared DEGs of ARVC vs. NF and DCM vs. NF, 1371 specific DEGs of ARVC vs. NF, and 1075 specific DEGs of DCM vs. NF were identified. The shared DEGs were enriched in 63 biological processes (BP), 11 molecular functions (MF), 10 cellular components (CC), and 25 KEGG pathways. The DEGs of ARVC vs. DCM were enriched in 71 BPs, 19 MFs, 14 CCs, and 26 KEGG pathways. A PPI network with 187 nodes, 700 edges, and 2 modules, and another PPI network with 575 nodes, 2834 edges, and 7 modules were constructed based on the shared and specific DEGs, respectively. The top ten hub genes CCR3, CCR5, CXCL2, CXCL10, CXCR4, FPR1, APLNR, PENK, BDKRB2, GRM8, and RPS8, RPS3A, RPS12, RPS14, RPS21, RPL14, RPL18A, RPL21, RPL31 were identified for the shared and specific PPI networks, respectively.Conclusions: Our findings may help further the understanding of both shared and specific potential molecular mechanisms of ARVC and DCM.

show abstract

CDK11p46 and RPS8 associate with each other and suppress translation in a synergistic manner

Cited by 20 publications

References 35 publications

Epsin Family Member 3 and Ribosome-Related Genes Are Associated with Late Metastasis in Estrogen Receptor-Positive Breast Cancer and Long-Term Survival in Non-Small Cell Lung Cancer Using a Genome-Wide Identification and Validation Strategy

Epsin Family Member 3 and Ribosome-Related Genes Are Associated with Late Metastasis in Estrogen Receptor-Positive Breast Cancer and Long-Term Survival in Non-Small Cell Lung Cancer Using a Genome-Wide Identification and Validation Strategy

Cyclin-dependent kinase 11 (CDK11) is crucial in the growth of liposarcoma cells

Identification Of Both Shared And Specific Potential Molecular Mechanisms Of Arvc And Dcm Based On A Genome-Wide Microarray Dataset

Contact Info

Product

Resources

About