CDK-related protein kinases in plants

Joubès, Jérôme; Chevalier, Christian; Dudits, Dénes; Heberle‐Bors, Erwin; Inzé, Dirk; Umeda, Masaaki; Renaudin, Jean-Pierre

doi:10.1007/978-94-010-0936-2_6

Cited by 108 publications

(171 citation statements)

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“…Concomitant to the expansion process, the nuclear DNA content in cells from the locular tissue increases according to the endoreduplication process (Joubès et al, 1999). Because endoreduplication corresponds to a partial cell cycle in which mitosis is omitted (Joubès and Chevalier, 2000), genes expressed at the G2/M transition and in the M phase such as G2/M-specific CDKBs (Joubès et al, 2000a(Joubès et al, , 2001) and mitotic cyclins (Joubès et al, 2000b) are switched off. LekdsA transcripts are no more detected in the gel tissue after 15 DPA (Fig.…”

Section: Discussionmentioning

confidence: 99%

The Gene Expression and Enzyme Activity of Plant 3-Deoxy-D-Manno-2-Octulosonic Acid-8-Phosphate Synthase Are Preferentially Associated with Cell Division in a Cell Cycle-Dependent Manner

et al. 2003

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3-Deoxy-d-manno-2-octulosonic acid-8-phosphate (Kdo-8-P) synthase catalyzes the condensation of phosphoenolpyruvate with d-arabinose-5-phosphate to yield Kdo-8-P. Kdo-8-P is the phosphorylated precursor of Kdo, a rare sugar only found in the rhamnogalacturonan II pectic fraction of the primary cell walls of higher plants and of cell wall polysaccharides of some green algae. A cDNA named LekdsA (accession no. AJ294902) encoding tomato (Lycopersicon esculentum) Kdo-8-P synthase has been isolated. The recombinant protein rescued a kdsA thermosensitive mutant of Salmonella typhimurium impaired in the synthesis of a functional Kdo-8-P synthase. Using site-directed mutagenesis of LekdsA cDNA, the tomato Kdo-8-P synthase was shown to possess the same essential amino acids that form the active sites in the bacterial enzymes. The tomato kdsA gene expression and the relevant Kdo-8-P synthase activity were preferentially associated to dividing cells, in the course of the early development of tomato fruit and in meristematic tissues. Furthermore, the transcription of the kdsA gene was found to oscillate during the cell cycle in tobacco (Nicotiana tabacum) Bright-Yellow 2 synchronized cells with a maximum during mitosis.

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Section: Discussionmentioning

confidence: 99%

The Gene Expression and Enzyme Activity of Plant 3-Deoxy-D-Manno-2-Octulosonic Acid-8-Phosphate Synthase Are Preferentially Associated with Cell Division in a Cell Cycle-Dependent Manner

et al. 2003

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“…The CDK-b proteins appear to fall into two subgroups on the basis of sequence relationships (Huntley and Murray, 1999;Umeda et al, 1999;Joubès et al, 2000). One group contains Arabidopsis CDC2b, snapdragon (Antirrhinum majus) Cdc2c, and alfalfa (Medicago sativa) cdc2MsD, which all contain the sequence PP-TALRE and for which the name CDK-b1 subgroup has been proposed (Hirayama et al, 1991;Imajuku et al, 1992;Hirt et al, 1993;Fobert et al, 1996;Segers et al, 1996;Magyar et al, 1997;Huntley and Murray, 1999).…”

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confidence: 99%

“…Previously, a cDNA of a PSTAIRE (CDK-a) gene cdc2Nt1 (renamed Nicta;CdkA;3 by Joubès et al, 2000) has been cloned from tobacco, and RNA gel-blot analysis showed this gene to be preferentially expressed in dividing BY-2 cells but not to show significant cell cycle regulation of transcript abundance (Setiady et al, 1996). A later study of CDC2a (CDK-a) protein levels and histone H1 kinase activities in propyzamide synchronized cells showed that the protein levels remained at a constant level throughout the cell cycle but that kinase activity was cell cycle regulated (Reichheld et al, 1999).…”

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confidence: 99%

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Cell Cycle Regulation of Cyclin-Dependent Kinases in Tobacco Cultivar Bright Yellow-2 Cells

et al. 2001

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Plants possess two major classes of cyclin-dependent kinases (CDK) with cyclin-binding motifs PSTAIRE (CDK-a) and PPTA/TLRE (CDK-b). Tobacco (Nicotiana tabacum L. cv Bright Yellow-2) cells are the most highly synchronizable plant culture, but no detailed analysis of CDK activities has been reported in this system. Here we describe isolation of new PPTALRE CDKs (Nicta;CdkB1) from Bright Yellow-2 cells and present detailed analysis of the mRNA, protein and kinase activity levels of CdkB1, and the PSTAIRE CDKA during the growth and cell cycles. CdkA and CdkB1 transcripts are more abundant in exponential than in stationary phase cells, but the two genes show strikingly different regulation during the cell cycle. CdkA mRNA and protein accumulate during G1 in cells re-entering the cell cycle, and immunoprecipitated histone H1 kinase activity increases at the G1/S boundary. Aphidicolin synchronized cells show the highest CDKA-associated histone H1 kinase activity during S-G2 phases, although CdkA mRNA and protein levels are not significantly regulated. In contrast, CdkB1 transcripts are present at very low levels until S phase and CDKB1 protein and kinase activity is almost undetectable in G1. CdkB1 mRNA accumulates through S until M phase and its associated kinase activity peaks at the G2/M boundary, confirming that transcription of PPTALRE CDKs is cell cycle regulated. We suggest that CDKA kinase activity likely plays roles at the G1/S phase boundary, during S phase, and at the G2/M phase transition, and that CDKB1 kinase activity is present only at G2/M.

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“…74 This peculiar pattern prompted us to re-investigate the evolutionary relationship of "PCTAIRE"-signature containing kinase genes in different model organisms. In "higher" eukaryotes, PCTAIREs, which are about 500 amino acid residues long, consist of a highly conserved CDK-like kinase domain (~50% identical to CDK1) and long N-and shorter C-terminal extensions.…”

Section: Pctaires and Pftaires: Eumetazoan-specific Genesmentioning

confidence: 99%