2016
DOI: 10.18632/oncotarget.9758
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CDH1 rs9929218 variant at 16q22.1 contributes to colorectal cancer susceptibility

Abstract: Colorectal cancer (CRC) is the third most common cancer. Large-scale genome-wide association studies (GWAS) have been performed and reported some novel CRC susceptibility variants in European ancestry including the CDH1 rs9929218. Following GWAS and candidate studies evaluated the association between the CDH1 rs9929218 polymorphism and CRC in European, Asian and American populations. However, these studies reported inconsistent associations. Evidence shows that rs9929218 may regulate different gene expressions… Show more

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Cited by 11 publications
(10 citation statements)
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References 50 publications
(48 reference statements)
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“…E‐cadherin biologically controls cell adhesion, cell polarity, and tissue morphology, and its loss is linked to promotion of cell migration and invasion in tumor cells . The rs9929218 variant has been shown to regulate CDH1 expression in different human tissues . The loss of CDH1 expression has also been related to indicators of poor prognosis, such as infiltrative tumor growth and metastasis in colorectal cancer …”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…E‐cadherin biologically controls cell adhesion, cell polarity, and tissue morphology, and its loss is linked to promotion of cell migration and invasion in tumor cells . The rs9929218 variant has been shown to regulate CDH1 expression in different human tissues . The loss of CDH1 expression has also been related to indicators of poor prognosis, such as infiltrative tumor growth and metastasis in colorectal cancer …”
Section: Discussionmentioning
confidence: 99%
“…34 The rs9929218 variant has been shown to regulate CDH1 expression in different human tissues. 35 The loss of CDH1 expression has also been related to indicators of poor prognosis, such as infiltrative tumor growth and metastasis in colorectal cancer. 36 Although SNP rs10936599 was associated with survival in our study, it showed no significant associations with survival in a previous study.…”
Section: Discussionmentioning
confidence: 99%
“…The alteration of CDH1 contributes to epithelial-mesenchymal transition, the biological phenomenon allowing epithelial cells to transition into fibroblastic cells with an ability to migrate and invade into the extracellular matrix (26,27) Because this molecule is responsible for adherens junctions between epithelial cells, it is implicated in tumor progression in carcinogenesis (28,29). A meta-analysis revealed that the polymorphism in CHD1 rs9929218 was associated with CRC (30). Moreover, the loss of CDH1 expression was associated with infiltrative tumor growth and lymph node metastasis (31).…”
Section: Discussionmentioning
confidence: 99%
“…The following data was gathered from each study: the name of the rst author, the year of publication, the country of study, the speci c number of genotypes in each control and case group; and the source of the control group (population-or hospital-based controls). Varying ethnic ancestries were classi ed as European, Asians, or Other including more than one ethnicity's subjects [14,18] .…”
Section: Data Extractionmentioning
confidence: 99%
“…Among these SNPs, rs9929218 (16p22.1), located in the intron region of the gene cadherin 1 (CDH1), was identi ed to be associated with CRC risk [14] . In 2016, Han et al conducted a meta-analysis of rs9929218 including 16 studies (n = 131768) which emphasizes a signi cant association between rs9929218 polymorphism and CRC susceptibility [14] . Nonetheless, its limitation is the absence of raw genotype data that reference dominant and recessive models.…”
Section: Introductionmentioning
confidence: 99%