Abstract:Timely mitosis is critically important for early embryo development. It is regulated by the activity of the conserved protein kinase CDK1. The dynamics of CDK1 activation must be precisely controlled to assure physiologic and timely entry into mitosis. Recently, a known S-phase regulator CDC6 emerged as a key player in mitotic CDK1 activation cascade in early embryonic divisions, operating together with Xic1 as a CDK1 inhibitor upstream of the Aurora A and PLK1, both CDK1 activators. Herein, we review the mole… Show more
“…The review article by El Dika and colleagues [ 4 ] summarizes how the timing of mitotic divisions is tuned by a mechanism dependent on CDC6 ATPase, which inhibits the major mitotic kinase CDK1 (or p34 cdc2 ). CDC6 was well known as a regulator of the S-phase of the cell cycle.…”
The correct timing of molecular and cellular events is critical for embryo development, cell/tissue homeostasis, and to functions in all organisms throughout their whole lives [...]
“…The review article by El Dika and colleagues [ 4 ] summarizes how the timing of mitotic divisions is tuned by a mechanism dependent on CDC6 ATPase, which inhibits the major mitotic kinase CDK1 (or p34 cdc2 ). CDC6 was well known as a regulator of the S-phase of the cell cycle.…”
The correct timing of molecular and cellular events is critical for embryo development, cell/tissue homeostasis, and to functions in all organisms throughout their whole lives [...]
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