CDC45 promotes the stemness and metastasis in lung adenocarcinoma by affecting the cell cycle
Yafeng Liu,
Tao Han,
Zhi Xu
et al.
Abstract:Objective
This study aimed to assess the functions of cell division cycle protein 45 (CDC45) in Non-small cell lung cancer (NSCLC) cancer and its effects on stemness and metastasis.
Methods
Firstly, differentially expressed genes related to lung cancer metastasis and stemness were screened by differential analysis and lasso regression. Then, in vitro, experiments such as colony formation assay, scratch assay, and transwell assay were conducted to e… Show more
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