Abstract:BackgroundHepatocellular carcinoma (HCC) is a malignancy with poor outcome. As an anti-tumor mechanism, the methylation pattern of gene in senescent cells is different from that in malignant ones deriving from physically senescent cells. Therefore, it is possible that aberrantly methylated senescence-associated genes could predict the prognosis of HCC patients.MethodsDifferentially expressed genes with aberrant methylation were explored in two senescent cell datasets and were selected as senescence-associated … Show more
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