CDC Recommendations for Hepatitis C Screening Among Adults — United States, 2020

Schillie, Sarah; Wester, Carolyn; Osborne, Melissa; Wesolowski, Laura G.; Ryerson, A. Blythe

doi:10.15585/mmwr.rr6902a1

Cited by 358 publications

(420 citation statements)

References 87 publications

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“…In support of increased screening, treatment, and improved linkage to care, the CDC, USPTF, and AASLD–IDSA have all provided updated guidance that supports universal screening recommendations. The universal screening guidelines indicate that all adults over the age of 18 years should be screened for HCV [ 6 – 8 ]. Additionally, AASLD–IDSA recommends that all patients with HCV infection should be treated, regardless of sobriety [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…An example of a country in which political will exists is Australia, which has an estimated elimination target of 2026, which is earlier than the 2030 WHO elimination target [ 16 ]. In the USA there is growing political will as evidenced by recent universal screening guidelines issued by the CDC and USPTF [ 6 , 8 ] and the CDC has designated May as Hepatitis C Awareness Month to encourage screening of high-risk populations [ 31 ]. Sustained political will and policy changes at the federal and state level as well as funding for efforts to reduce HCV incidence and prevalence are required for HCV elimination.…”

Section: Discussionmentioning

confidence: 99%

“…The number of new cases of HCV infection among this demographic has increased from 10,000 annually in 2005 to 40,000 annually in 2016 [ 5 ]. Owing to these increases in HCV infections among younger individuals, the Centers for Disease Control and Prevention (CDC), the US Preventive Services Task Force (USPTF), and the American Association for the Study of Liver Diseases–Infectious Diseases Society of America (AASLD–IDSA) have all endorsed universal screening for HCV in adults (≥18 years of age) [ 6 – 8 ]. Chronic HCV infection is characterized by progressive liver fibrosis and the potential development of cirrhosis and hepatocellular carcinoma (HCC) [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

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Estimating the Year Each State in the United States Will Achieve the World Health Organization’s Elimination Targets for Hepatitis C

et al. 2020

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Introduction Although hepatitis C virus (HCV) infection remains a major clinical, economic, and societal burden, the development of curative antiviral therapy may accelerate the path toward elimination. This analysis assessed the progress of United States (US) states towards achieving the World Health Organization’s (WHO) 2030 HCV elimination targets for incidence, mortality, diagnosis, and treatment. Methods A previously published Markov model was used to simulate HCV progression over time to estimate the path to HCV elimination in each state based on prevalence, annual treatment, and diagnosis inputs from two large US laboratory datasets from January 2013 to December 2017. State-specific fibrosis stage restrictions on treatment in 2017 were included. The model estimated the year individual states would meet the WHO targets for diagnosing 90% of the HCV-infected population, treating 80% of the eligible population, reducing new HCV infections by 80%, and reducing HCV-related deaths by 65%. The minimum number of annual treatments needed between 2020 and 2030 to achieve the WHO treatment target was also calculated. Results Overall, the USA is projected to achieve HCV elimination by 2037, with individual targets related to mortality, diagnosis, treatment, and incidence being achieved by 2020, 2027, 2033, and 2037, respectively. Three states (Connecticut, South Carolina, and Washington) are on track to meet all four elimination targets by 2030, and 18 states are not expected to meet these targets before 2040. The estimated annual number of treatments required during 2020–2030 nationally to reach the WHO treatment target is 173,514. Conclusion With the exception of three states, the USA is not on target to meet the WHO 2030 elimination targets and 35% are off track by 10 years or more. Strategies must be implemented to reduce overall prevalence by preventing new infections, increasing rates of screening, improving linkage to care, and implementing unfettered access to curative therapy. Electronic supplementary material The online version of this article (10.1007/s12325-020-01535-3) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Estimating the Year Each State in the United States Will Achieve the World Health Organization’s Elimination Targets for Hepatitis C

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“…Despite expanded CDC guidelines for universal HCV screening, which now includes all adults [9], screening remains a challenge for higher risk patients with less access to care [7,[10][11][12][13]. Nonetheless, there have been successful screening programs described for such populations [14,15].…”

Section: Discussionmentioning

confidence: 99%

Hepatitis C antibody screening and determinants of initial and duplicate screening in the baby boomer patients of six urban primary care clinics

et al. 2020

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“…The Affordable Care Act requires private insurers and Medicaid to cover preventive services recommended by the USPSTF with a grade of A or B with no cost sharing (ie, no deductible or co-payment). 9 These recommendations are nearly identical to those of the American Association for the Study of Liver Diseases and Infectious Diseases Society of America 10 and the Centers for Disease Control and Prevention, 11 the latter of which are still in draft form. The notable difference between the USPSTF recommendations 7 and the American Association + Audio + Related article at jama.com for the Study of Liver Diseases and Infectious Diseases Society of America recommendations 10 is that the latter include a lower-graded recommendation for annual HCV screening for PWID and HIV-infected men who have unprotected sex with men.…”

mentioning

confidence: 91%

USPSTF’s Hepatitis C Screening Recommendation—A Necessary Step to Tackling an Evolving Epidemic

Rosenberg

Barocas

2020

JAMA Netw Open

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Hepatitis C virus (HCV) is a cause of significant morbidity and mortality in the United States, with an estimated 4.1 million adults ever infected and 2.4 million adults currently infected. 1,2 Left untreated, HCV infection can lead to liver fibrosis, cirrhosis, and hepatocellular carcinoma and is associated with more than 20 000 deaths in the United States annually. 1,2 The burden of illness is not uniform across age, with persons born between 1945 and 1965, otherwise known as the "birth cohort," representing the majority of prevalent infections. This evidence led the US Preventive Services Task Force (USPSTF) in 2013 to recommend offering 1-time HCV screening of members of the birth cohort, along with periodic screening of those at continued risk, at unspecified intervals. 3 That previous recommendation was an incremental step away from risk-based screening and was based on the evidence that the birth cohort had the highest prevalence, had acquired their infections in the distant past (through blood transfusions or previous injection drug use), and had little ongoing risk. Yet, over Author affiliations and article information are listed at the end of this article.

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CDC Recommendations for Hepatitis C Screening Among Adults — United States, 2020

Cited by 358 publications

References 87 publications

Estimating the Year Each State in the United States Will Achieve the World Health Organization’s Elimination Targets for Hepatitis C

Estimating the Year Each State in the United States Will Achieve the World Health Organization’s Elimination Targets for Hepatitis C

Hepatitis C antibody screening and determinants of initial and duplicate screening in the baby boomer patients of six urban primary care clinics

USPSTF’s Hepatitis C Screening Recommendation—A Necessary Step to Tackling an Evolving Epidemic

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