CDC Grand Rounds: Family History and Genomics as Tools for Cancer Prevention and Control

Rodriguez, Juan L.; Thomas, Cheryll C.; Massetti, Greta M.; Duquette, Debra; Avner, Lindsay; Iskander, John K.; Khoury, Muin J.; Richardson, Lisa C.

doi:10.15585/mmwr.mm6546a3

Cited by 16 publications

(25 citation statements)

References 12 publications

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“…11 Each year, Lynch syndrome accounts for 1%-3% of all colorectal cancer cases. 12 For Lynch syndrome, in our department in Somalia could not studied using immunohistochemistry (MSH2, MLH1, PMS2), microsatellite instability, (analysis with the Bethesda panel), mononucleotide markers (D2S123, D5S346, D17S250), dinucleotide markers (BAT25, and BAT26) and DNA mismatch repair gene (i.e., MSH2, MLH1, MSH6) because of it was very expensive. 13 In conclusion, our patient was originally a case of MAC with synchronous bilateral giant KT and PC.…”

Section: Discussionmentioning

confidence: 99%

Synchronized Bilateral Giant Krukenberg Tumor Originating from the Colon

Baş¹,

Kalyoncu²,

Bulgan³

et al. 2018

Turkiye Klinikleri J Case Rep

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Section: Discussionmentioning

confidence: 99%

Synchronized Bilateral Giant Krukenberg Tumor Originating from the Colon

Baş¹,

Kalyoncu²,

Bulgan³

et al. 2018

Turkiye Klinikleri J Case Rep

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“…Two of these Tier 1 tests are Healthy People 2020 (HP2020) objectives. One of these HP2020 objectives is to increase the number of adult women with a significant family history of breast and/or ovarian cancer referred to genetic counseling and consideration of genetic testing . The other HP2020 genomics objective is to increase the proportion of colorectal cancers screened for Lynch syndrome or other hereditary colorectal cancer .…”

Section: Genetic Tests With Public Health Dental Implications: Which mentioning

confidence: 99%

Implementation of public health genomics and applications to public health dentistry

Duquette

2019

J Public Health Dent

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National and state public health genomics efforts exist to effectively and responsibly translate genome‐based knowledge to improve population health and reduce health disparities. Over the past two decades, public health genomics efforts have utilized the core public health functions of assessment, policy development, and assurance. Current evidence for a small number of genomic applications suggests that many lives could be saved if these were implemented in recommended populations. With the drastic increase in new genetic tests and technologies, multidisciplinary public health genomics efforts that should include public health dentistry are of greater importance. There is a need to integrate public health dentistry in efforts to increase use of evidence‐based genomic tests and services to improve health outcomes. Additionally, public health genomic efforts also are utilized to promote awareness about the insufficient evidence of the validity, utility and ethical, legal, and social implications for the vast majority of genomic tests. This is demonstrated by a recent genetic testing policy statement and educational resources from the American Dental Association. These organizational efforts should be considered in other realms of public health genomics to ensure that only genetic tests and preventive services with sufficient evidence for use are being implemented in clinical and public health.

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“…Genomics is becoming an increasingly important field in the U.S., particularly with regard to its usefulness in precision medicine [42]. CDC has held several workshops and meetings to promote incorporation of genomic and genetic testing awareness and uptake into public health practice [43,44]. Particular focus areas have been increasing awareness of and surveillance for cancer-promoting genetic mutations such as BRCA1/BRCA2 and those associated with Lynch syndrome that predispose individuals to breast, ovarian, colorectal, uterine, and other cancers [44].…”

Section: Emphasizing the Primary Prevention Of Cancermentioning

confidence: 99%

“…CDC has held several workshops and meetings to promote incorporation of genomic and genetic testing awareness and uptake into public health practice [43,44]. Particular focus areas have been increasing awareness of and surveillance for cancer-promoting genetic mutations such as BRCA1/BRCA2 and those associated with Lynch syndrome that predispose individuals to breast, ovarian, colorectal, uterine, and other cancers [44]. A 2005 review noted that 56% of state plans analyzed had begun to implement genomics components described in their plan [45].…”

Section: Emphasizing the Primary Prevention Of Cancermentioning

confidence: 99%

“…This work does extend to NCCCP-funded areas of relatively low resources, such as the USAPIJs. In Yap USAPIJ, comprehensive cancer control practitioners held educational workshops to increase knowledge of cervical cancer screening and showed an approximate 25% increase in knowledge of Pap smear screening recommendations among the 326 women attending the workshops [44]. And a cross-sectional survey of 72 health care providers from five of the six USAPIJ funded by the NCCCP showed that most providers reported cervical cancer prevention as a priority in their clinical practices (90.3%) and used Pap smear screening (86.1%) [49].…”

Section: Promoting Early Detection Of Cancermentioning

confidence: 99%

See 1 more Smart Citation

Combating Cancer Through Public Health Practice in the United States: An In-Depth Look at the National Comprehensive Cancer Control Program

Stewart¹,

Hayes²,

Moore³

et al. 2018

Public Health - Emerging and Re-Emerging Issues

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Cancer is the second leading cause of the death in the United States (U.S.). The National Comprehensive Cancer Control Program (NCCCP) is a national, public health practice program funded by the U.S. Centers for Disease Control and Prevention. The NCCCP has been planning and implementing interventions to reduce the burden of cancer since 1998. Interventions are implemented across three areas primary prevention, early detection, and survivorship using health systems and environmental changes to promote sustainable cancer control. The aim of this chapter is to provide a summary of the NCCCP, and highlight specific examples of interventions and successes to aid cancer planning in other countries. Cancer plan analyses show that all NCCCP participant cancer plans address reducing tobacco use for cancer prevention and 98% contain activities to increase colorectal cancer screening. The vast majority implement activities to improve the quality of life following a cancer diagnosis (94%). Relatively fewer cancer plans contain activities to reduce radon exposure (42%), promote human papilloma virus vaccination (62%), and incorporate the use of genomics in cancer control (56%). The examples of NCCCP activities demonstrate success in controlling cancer and other non-communicable diseases through public health practice.

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CDC Grand Rounds: Family History and Genomics as Tools for Cancer Prevention and Control

Cited by 16 publications

References 12 publications

Synchronized Bilateral Giant Krukenberg Tumor Originating from the Colon

Synchronized Bilateral Giant Krukenberg Tumor Originating from the Colon

Implementation of public health genomics and applications to public health dentistry

Combating Cancer Through Public Health Practice in the United States: An In-Depth Look at the National Comprehensive Cancer Control Program

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