CD99 ligation induces intercellular cell adhesion molecule-1 expression and secretion in human gingival fibroblasts

Krisanaprakornkit, Suttichai; Chotjumlong, Pareena; Pata, Supansa; Chruewkamlow, Nuttapol; Reutrakul, Vichai

doi:10.1016/j.archoralbio.2012.06.011

Cited by 10 publications

(7 citation statements)

References 39 publications

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“…Consistent with no ADAM8 mRNA expression in HGFs, expression of membrane ADAM8 was not found on the surface of HGFs (Fig. C), but CD99 was constitutively expressed on their surface . A marked increase in ADAM8 expression (punctate staining) was observed in HGECs stimulated with F.n .CW compared with low levels of ADAM8 expression in control HGECs (Fig.…”

Section: Resultssupporting

confidence: 69%

Inducible expression of A Disintegrin and Metalloproteinase 8 in chronic periodontitis and gingival epithelial cells

Aung

Chotjumlong

Pata

et al. 2016

J of Periodontal Research

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Section: Resultssupporting

confidence: 69%

Inducible expression of A Disintegrin and Metalloproteinase 8 in chronic periodontitis and gingival epithelial cells

Aung

Chotjumlong

Pata

et al. 2016

J of Periodontal Research

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“…[ 17a ] Meanwhile, we found that CAMs pathways were closely related to the dense stroma characteristics of PDAC. Among the enriched CAMs, ICAM1 , [ 19 ] ITGA8 , [ 20 ] CD99 , [ 21 ] JAM2 , [ 22 ] GLG1 , [ 23 ] CDH1 , [ 24 ] and OCLN , [ 25 ] have been shown to participate in stroma or fibroblasts activation. [ 26 ] Therefore, we asked whether lnc‐FSD2‐31:1 was involved in CAFs activation.…”

Section: Resultsmentioning

confidence: 99%

Tumor Cell Derived Lnc‐FSD2‐31:1 Contributes to Cancer‐Associated Fibroblasts Activation in Pancreatic Ductal Adenocarcinoma Progression through Extracellular Vesicles Cargo MiR‐4736

Geng

Luo

et al. 2023

Advanced Science

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Pancreatic ductal adenocarcinoma (PDAC) presents with high mortality and short overall survival. Cancer‐associated fibroblasts (CAFs) act as refuge for cancer cells in PDAC. Mechanisms of intracelluar communication between CAFs and cancer cells need to be explored. Long noncoding RNAs (lncRNAs) are involved in the modulation of oncogenesis and tumor progression of PDAC; however, specific lncRNAs and their mechanism of action have not been clarified clearly in tumoral microenvironment. This work aims to identify novel lncRNAs involved in cellular interaction between cancer cells and CAFs in PDAC. To this end, differentially expressed lncRNAs between long‐term and short‐term survival PDAC patients are screened. Lnc‐FSD2‐31:1 is found to be significantly increased in long‐term survival patients. This work then discovers that tumor‐derived lnc‐FSD2‐31:1 restrains CAFs activation via miR‐4736 transported by extracellular vesicles (EVs) in vitro and in vivo. Mechanistically, EVs‐derived miR‐4736 suppresses autophagy and contributes to CAFs activation by targeting ATG7. Furthermore, blocking miR‐4736 suppresses tumor growth in genetically engineered KPC (LSL‐KrasG12D/+, LSL‐Trp53R172H/+, and Pdx‐1‐Cre) mouse model of PDAC. This study demonstrates that intratumoral lnc‐FSD2‐31:1 modulates autophagy in CAFs resulting in their activation through EVs‐derived miR‐4736. Targeting miR‐4736 may be a potential biomarker and therapeutic target for PDAC.

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“…CD97 (adhesion G protein‐coupled receptor E5) that plays a critical role in cell adhesion related to leukocyte recruitment, activation and migration was increased following biofilm challenge. CD99 expression has been shown in the periodontium, including gingival fibroblasts, endothelial and epithelial cells . Finally, CD274 (PDL1; B7‐H1) is a ligand that binds to the PD1 receptor and can inhibit T‐cell activation and cytokine production.…”

Section: Discussionmentioning

confidence: 99%

“…CD99 expression has been shown in the periodontium, including gingival fibroblasts, endothelial and epithelial cells. 61 Finally, CD274 (PDL1; B7-H1) is a ligand that binds to the PD1 receptor and can inhibit T-cell activation and cytokine production. Challenge of primary gingival keratinocytes and oral epithelial cells with P. gingivalis showed an upregulation of CD274 that was not observed with an oral commensal bacterium.…”

Section: Pathogenic Biofilm Stimulation Of Gene Expression By Oral mentioning

confidence: 99%

Environmental lead effects on gene expression in oral epithelial cells

Peyyala

Emecen‐Huja

Ebersole

2018

J of Periodontal Research

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CD99 ligation induces intercellular cell adhesion molecule-1 expression and secretion in human gingival fibroblasts

Cited by 10 publications

References 39 publications

Inducible expression of A Disintegrin and Metalloproteinase 8 in chronic periodontitis and gingival epithelial cells

Inducible expression of A Disintegrin and Metalloproteinase 8 in chronic periodontitis and gingival epithelial cells

Tumor Cell Derived Lnc‐FSD2‐31:1 Contributes to Cancer‐Associated Fibroblasts Activation in Pancreatic Ductal Adenocarcinoma Progression through Extracellular Vesicles Cargo MiR‐4736

Environmental lead effects on gene expression in oral epithelial cells

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