CD9 induces cellular senescence and aggravates atherosclerotic plaque formation

Human Adipose-Derived Stem Cells in Madelung’s Disease: Morphological and Functional Characterization

“…The significant lower levels of CD9 reported in MD-ASC has never been reported in the literature as a feature of lipomas. Although considered a stem cell marker, it has been recently shown that downregulation of CD9 expression can protect from cellular senescence [40]. CD9 was shown to act through a phosphatidylinositide 3 kinase-AKT-mTOR-p53 signal pathway and it would be interesting in the future to investigate this pathway in MD-ASC.…”

The aging endothelium

“…Such changes cause accumulation of LDL in the sub-endothelial space resulting in enhanced EC expression of adhesion molecules such as vascular cell adhesion molecule 1 (VCAM1), E- and P-Selectins to promote leukocyte recruitment ( 73 ). CD9, a novel senescence-related marker was reported to be increased in aged human arteries and mice ( 74 ). In mouse models of atherosclerosis, CD9 expression was co-expressed with SA-β-gal staining and was found the be upregulated in ECs and macrophages within lesions.…”

CD82 Protects Against Glaucomatous Axonal Transport Deficits via mTORC1 Activation in Mice

“…For example, tetraspanin 8 interacted with rictor, a key component of mTOR complex 2 (mTORC2) in malignant glioma (22). CD9 (TSPAN29) induced senescence in human endothelial cells via regulating PI3K/AKT-mTOR pathway (23). It is also reported that CD82 overexpression in multiple myeloma cell lines resulted in upregulation of phospho-S6 ribosomal protein, an established target of mTORC1 (24).…”