2005
DOI: 10.4049/jimmunol.174.11.6757
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CD85j (Leukocyte Ig-Like Receptor-1/Ig-Like Transcript 2) Inhibits Human Osteoclast-Associated Receptor-Mediated Activation of Human Dendritic Cells

Abstract: Immature dendritic cells (DCs) derived from freshly isolated human monocytes were used to evaluate the effect of the inhibiting receptor CD85j (leukocyte Ig-like receptor-1/ILT2) on activation induced by cross-linking of the human osteoclast-associated receptor (hOSCAR). CD85j and hOSCAR were expressed consistently at the same density on monocytes and on monocyte-derived DCs (both immature and mature). Cross-linking of hOSCAR, which activates via the FcR-associated γ-chain, induced Ca2+ flux in DCs. Concomitan… Show more

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Cited by 42 publications
(41 citation statements)
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“…In DCs, cross-linking of OSCAR with specific mAbs enhanced Ag presentation and promoted a semimature phenotype, causing chemokine but not proinflammatory cytokine secretion. In synergy with TLR signaling, but not alone, OSCAR cross-linking enhanced the ability of DCs to induce naive CD4 + T cell prolifer-ation (9,11,12). It was concluded that OSCAR can induce a semimatured phenotype in DCs, which is characterized by expression of costimulatory molecules but an inability to secrete proinflammatory cytokines.…”
mentioning
confidence: 96%
“…In DCs, cross-linking of OSCAR with specific mAbs enhanced Ag presentation and promoted a semimature phenotype, causing chemokine but not proinflammatory cytokine secretion. In synergy with TLR signaling, but not alone, OSCAR cross-linking enhanced the ability of DCs to induce naive CD4 + T cell prolifer-ation (9,11,12). It was concluded that OSCAR can induce a semimatured phenotype in DCs, which is characterized by expression of costimulatory molecules but an inability to secrete proinflammatory cytokines.…”
mentioning
confidence: 96%
“…They can induce the release of cytokines and modulate co-stimulatory receptor expression on professional APC [1,2,23], which in turn, shape T-cell responses [1][2][3][4]. LILR expression is largely confined to myeloid cell types.…”
Section: Introductionmentioning
confidence: 99%
“…LILR expression is largely confined to myeloid cell types. LILRB1 is also expressed on B cells, T cells and NK cells and it has been shown to inhibit the responses of NK cells [24], T cells [25][26][27] and DC [23].…”
Section: Introductionmentioning
confidence: 99%
“…[10][11][12] The work of Suciu-Foca and co-workers has demonstrated the potent tolerogenic effects of two other family members: LILRB2 and LILRB4. Expression of these receptors was strongly enhanced in DCs exposed to alloantigen-specific CD8 + CD28…”
Section: The Influence Of Lilrs On Antigen-presenting Functionmentioning
confidence: 99%
“…LILRB1 is upregulated throughout DC differentiation and its engagement during this process results in a failure of DCs to respond to maturation stimuli. [10][11][12] DCs that are maintained in an immature state through LILRB1 engagement cannot stimulate effective T-cell responses; this effect seems to be mediated through the interaction between CD80 and cytotoxic T-lymphocyte antigen-4.…”
Section: The Influence Of Lilrs On Antigen-presenting Functionmentioning
confidence: 99%