CD81-guided heterologous EVs present heterogeneous interactions with breast cancer cells
Elena Gurrieri,
Giulia Carradori,
Michela Roccuzzo
et al.
Abstract:Extracellular vesicles (EVs) are cell-secreted particles conceived as natural vehicles for intercellular communication. The intrinsic biocompatibility, stability in biofluids, and heterogeneous molecular cargo of EVs promise advancements in targeted therapy applications. However, predicting cell-targeting spectrum and cargo delivery are fundamental challenges for exploiting EVs or hybrid formulations. In this work, we combined cell-based and biochemical approaches to understand if secreted EVs show predictable… Show more
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