CD80 on Human T Cells Is Associated With FoxP3 Expression and Supports Treg Homeostasis

Abstract

CD80 and CD86 are expressed on antigen presenting cells (APCs) and their role in providing costimulation to T cells is well established. However, it has been shown that these molecules can also be expressed by T cells, but the significance of this observation remains unknown. We have investigated stimuli that control CD80 and CD86 expression on T cells and show that in APC-free conditions around 40% of activated, proliferating CD4+ T cells express either CD80, CD86 or both. Expression of CD80 and CD86 was strongly dependent upon provision of CD28 costimulation as ligands were not expressed following TCR stimulation alone. Furthermore, we observed that CD80+ T cells possessed the hallmarks of induced regulatory T cells (iTreg), expressing Foxp3 and high levels of CTLA-4 whilst proliferating less extensively. In contrast, CD86 was preferentially expressed on INF-γ producing cells, which proliferated more extensively and had characteristics of effector T cells. Finally, we demonstrated that CD80 expressed on T cells inhibits CTLA-4 function and facilitates the growth of iTreg. Together these data establish endogenous expression of CD80 and CD86 by activated T cells is not due to ligand capture by transendocytosis and highlight clear differences in their expression patterns and associated functions.

Memory CD4+ T cells that co-express PD1 and CTLA4 have reduced response to activating stimuli facilitating HIV latency

“… 41 , 42 CD86 and CD80, the ligands for CTLA4, have also been shown to be expressed on CD4 + and CD8 + T cells. 43 , 44 …”

Codelivery of HBx-siRNA and Plasmid Encoding IL-12 for Inhibition of Hepatitis B Virus and Reactivation of Antiviral Immunity

“…HBx interacts with IPS-1 and RIG-1 to inhibit the activation of type 1 interferon [ 39 , 42 ]. CD80 activates the T-cell costimulatory receptor CD28 [ 43 , 44 ]. HLA class I (HLA-I) glycoproteins present antigens to cognate CD8 + T cells for driving immune responses [ 45 , 46 ].…”

“…Previous studies have shown that there is a certain relationship and the expression of IPS-1 and PD-L1 [37][38][39], but the specific mechanism study. As it is well known, IPS-1 and RIG-1 trigger the signaling pathway o feron, which is an important part of antiviral activity in innate immunit interacts with IPS-1 and RIG-1 to inhibit the activation of type 1 interferon activates the T-cell costimulatory receptor CD28 [43,44]. HLA class I (HL teins present antigens to cognate CD8 + T cells for driving immune respons upregulation of IPS-1, RIG-1, CD80, and HLA-1 indicates that the codeliv would promote antiviral immune responses.…”

Polarization of macrophages: mechanisms, markers and factors of induction

“…iNOS является ферментом, участвующим в продукции важного провоспалительного цитотоксического агента оксида азота (NO), который защищает хозяина от различных патогенов путем инактивации и уничтожения инфекционных агентов [53]. CD80 и CD86 располагаются на поверхности антигенпрезентирующих клеток и отвечают за передачу сигналов Т-клеткам, когда они взаимодействуют со своими лигандами CD152 и CD28 [54]. FcgRI (CD64), FcgRII (CD32) и FcgRIII (CD16) являются рецепторами Fc-γ (FcgR), которые опосредуют фагоцитоз, высвобождение медиаторов воспаления и стимуляцию иммунного ответа в макрофагах [55].…”